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| 1 | 太阴肺湿热瘟病(冠状病毒性肺炎)防治指南显示文摘温病包括了温、瘟、疫、疠四类,太阴肺湿热瘟病(含疫病与疠病)主要包括多种涉及肺的传染病,如肺出血性钩端螺旋体病、肺鼠疫、冠状病毒性肺炎等。冠状病毒性肺炎分早期(轻型,湿重于热)、中期(重型,湿热并重)、坏病(危重型)与后遗症期,对其诊断、治疗、预后、预防与调养分别给出临床指引。 | 吴雄志 | 2020 | TMR经典中医研究2020，3，2： | 17 |
| 2 | Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer: a meta-analysis显示文摘目的:系统评价参芪扶正注射液联合吉西他滨加顺铂(GP)化疗方案治疗晚期非小细胞肺癌(Non-smallcelllungcancer,NSCLC)的临床疗效.方法:计算机检索Cochrane Library,Pubmed,Embase,中国期刊全文数据库,中国生物医学文献数据库,中国科技期刊全文数据库和万方数据库等,检索时间限定为建库至2017年1月30日,检索关于参芪扶正注射液联合GP化疗方案治疗晚期非小细胞肺癌的随机对照实验(randomized controlled trial,RCT),参照Cochrane系统评价的要求,对所有评价参芪扶正注射液联合吉西他滨加顺铂(GP)化疗方案治疗晚期非小细胞肺癌(NSCLC)的随机对照试验进行方法学质量评价、数据提取和数据分析.结果:最终纳入8个研究,共701例患者.参芪扶正注射液联合GP化疗方案能显著提高晚期非小细胞肺癌患者的功能状态(OR=3.44,95%CI[2.26,5.25],P〈0.0001)和临床疗效(OR=1.54,95%CI[1.11,2.13],Z=2.60P=0.009),能预防GP化疗方案引起的白细胞下降(OR=0.31,95%CI[0.20,0.47],P〈0.0001)、血小板下降(OR=0.58,95%CI[0.37,0.91],P=0.02)、血红蛋白的下降(OR=0.31,95%CI[0.16,0.59],P=0.0004)及胃肠道反应的发(OR=0.38,95%CI[0.24,0.60],P=0.0001).结论:参芪扶正注射液联合GP化疗方案治疗晚期非小细胞肺癌临床疗效显著,但纳入文献质量低,结论有待高质量的研究加以证明. | Qiang Zhang Yi-Huan Fan Teng Zhang Xiao-Lan Qin Ji-Fang Song | 2017 | TMR Integrative Medicine2017，1，2： | 11 |
| 3 | Mechanisms involved in antineuralgic effects of Paeonia Lactiflora: prediction based on network pharmacology显示文摘目的:白芍的镇痛作用已被广泛应用于中医临床,但对其潜在机制知之甚少.本研究旨在从网络药理学的角度阐明其有效成分和镇痛机制.方法:通过中药系统药理学分析平台(TCMSP)筛选出其可能的活性成分及CAS.从Pubchem 中获得其SMILES,并通过在Swiss Target Prediction 数据库中反向对接获得潜在的靶点.从GeenCards 数据库中提取疼痛相关分子,采用韦恩图筛选出芍药治疗疼痛的预测靶点.机制分析采用String 构建蛋白-蛋白相互作用,运用DAVID 平台进行靶点GO 功能富集和KEGG 信号通路富集.结果:通过GO 和KEGG 分析我们发现疼痛相关的信号通路主要涉及血清素能突触、钙信号通路、调控TRP 通道的炎症介质.利用基于网络的系统生物学和分子对接分析,我们预测了白芍中的11 种活性成分和97 个潜在的治疗靶标.PRKCA、CASP3、ALOX15、SLC6A4、PRKCG、ALOX5、PRKCB、ALOX12、 EGFR、ADRB2、RYR3、RYR1、NOS2、PTAFR、PRKCQ、PRKCD 等基因参与了白芍的镇痛作用.结论:白芍可通过调节TRP 通道炎症介质、钙信号通路和5-羟色胺受体减轻疼痛.PRKCA、PRKCB、PRKCD、 PRKCQ 和PRKCG 可能是疼痛治疗的新靶标. | Di Zhang Shengsuo Ma Jianxin Sun Bing Yang Haoming Lin Meijing Xie Meina Huang Guoping Zhao | 2019 | TMR Clinical Research2019，2，2： | 8 |
| 4 | 从燥邪论治干眼的理论与治疗探讨显示文摘干眼的主要临床表现为干涩感,这与中医“燥胜则干”的理论相符。笔者查阅文献,未曾有人系统地从燥邪角度论治干眼。本文主要从中医基础理论、高危因素、实验依据与临床证据四大方面论述燥邪与干眼的因果联系,并讨论寒燥、热燥、内燥三种燥邪所致干眼类型的临床表现与治疗,以阐明燥邪致干眼的重要性,扩大其临床应用并提高治疗效果。 | 陈立浩 | 2019 | TMR经典中医研究2019，2，1： | 6 |
| 5 | 针灸结合康复训练综合治疗中风后肩手综合征研究进展显示文摘肩手综合征是脑中风患者常见的并发症,目前无特异性治疗方法。针灸、康复训练在治疗肩手综合征方面各有所长,研究表明二者结合治疗优势明显,疗效优于单一疗法。本文通过对近五年针灸结合康复训练治疗中风后肩手综合征的临床研究进行综述,佐证综合治疗的临床效果,最大限度地为患者提供最优诊疗服务。 | 舒杨 秦瑜玲 | 2019 | TMR经典中医研究2019，2，3： | 5 |
| 6 | 吴门验方“阳和散结汤”治疗乳腺癌理论浅析显示文摘乳腺癌是女性最高发的恶性肿瘤,其发病率逐年上升,严重危害女性身心健康。吴雄志教授从事中医临床工作近20年,对肿瘤疾病有深刻的认识,所拟吴门验方“阳和散结汤”注重乳腺癌的病因与病位,采用中西汇通的思想,提高了对乳腺癌的治疗效果。 | 成艳丽 彭涛 张国华 | 2018 | TMR经典中医研究2018，1，1： | 5 |
| 7 | Narrative nursing for cancer patients:a meta-analysis显示文摘Objective:To systematically review the effect of narrative nursing for cancer patients.Methods:Systematic searches in PubMed,EMBASE,The Cochrane Library,Web of Science,Chinese biomedical literature database,China National Knowledge Infrastructure,Wanfang medical and VIP database were performed for randomized controlled trials(RCTs)or quasi-RCTs which explored the effects of narrative nursing mode for cancer patients.Then,meta-analysis was performed by RevMan 5.3 after two independent investigators screened the literature,extracted the data and evaluated the risk of bias of all included studies.Results:A total of 15 studies were included,including 1778 cancer patients.The meta-analysis showed that narrative nursing could effectively relieve patients'anxiety and depression compared with the conventional nursing model(WMD=-9.04,95%CI=-11.82,-6.27;P<0.001),reduce the the inner shame(WMD=-2.28,95%CI=-3.76,-0.88;P=0.001),improved the mental resilience(WMD=18.20,95%CI=3.30,33.11;P<0.001)and the quality of life.Conclusion:This study has been systematically evaluated to show that narrative care can effectively improve the negative mood of patients with cancer and improve their quality of life.However,subject to the quality limitations of the included studies,the appeal conclusions are yet to be tested in more high-quality studies. | Min Zhang Ying-Ming Sun Na Sun Ya-Nan Leng | 2019 | TMR Cancer2019，2，4： | 3 |
| 8 | 抓独法在中医妇科中的应用刍议显示文摘本文介绍了作为六经模型运用五法之一的抓独法的概念、源流,以及与经方派抓主证的区别。还介绍抓独法有抓证法、抓枢法与抓病法三种方法,并指出四诊均可抓独。最后,从经典到临床介绍抓独法在中医妇科中的应用范例及体会。 | 沈佳 | 2020 | TMR经典中医研究2020，3，1： | 3 |
| 9 | 基于六经模型对太阴虚劳小建中汤条文的探讨显示文摘对仲景太阴虚劳小建中汤条文的理解,学术界有多种看法,本文基于六经模型,结合《伤寒论》与《金匮要略》相关条文,对小建中汤条文进行探讨,以期剖析其内在含义。 | 沈佳 | 2018 | TMR经典中医研究2018，1，1： | 3 |
| 10 | Advances in anti-tumor mechanism and clinical application of Astragalus polysaccharides显示文摘Astragalus polysaccharide has the beneficial effect of Qi-deficiency,and it also has several anti-tumor mechanisms,including pharmacological actions and clinical functions.Through literature review,this work concluded anti-tumor mechanism and clinical application of astragalus polysaccharide,which was of considerable significance to expand and optimize its anti-tumor function and clinical application. | Shan-Qi Guo Xiao-Jiang Li Ying-Jie Jia | 2020 | TMR Cancer2020，3，2： | 3 |
| 11 | Kangfuxin Fluid on the Treatment of Ulcerative Colitis with Retention Enema: a Systematic Review显示文摘目的:系统评价康复新液在保留灌肠治疗溃疡性结肠炎中的作用.方法:计算机检索中国期刊全文数据库、维普期刊资源整合平台、万方数据库、PubMed、Medline、Cochranelibrary、Embase数据库;并手工检索纳入文献的参考文献.检索时间为建库至2017年.对检索到的随机对照试验进行了系统的回顾,用RevMan5.3软件进行meta分析.结果:共纳入18篇随机对照试验,1417例患者,其中试验组731例,对照组686例.Meta分析显示,康复新液联合保留灌肠治疗溃疡性结肠炎的疗效显著优于对照治疗(RR=1.2295%CI:[1.16,1.27],Z=8.14,p〈0.00001),康复新液治疗后生活质量评分显著提高(MD=11.12,95%CI[7.00,15.23],Z=5.30,p〈0.00001).结论:康复新液联合保留灌肠治疗溃疡性结肠炎能提高患者的生活质量,值得临床推广.同时,有必要对溃疡性结肠炎的治疗效果进行深入的研究并进行高质量的随机对照试验. | Si-Yuan Yang Yuan Jia Li-Min Guo Fan-Jie Meng | 2018 | TMR Modern Herbal Medicine2018，1，3： | 3 |
| 12 | Bitter components related to alleviating intestinal obstruction in traditional Mongolian medicine显示文摘Intestinal obstruction is a blockage that keeps digesta from passing through upper or lower intestine.Traditional Mongolian medicine(TMM)has been proven to be efficacious in the clinical treatment of intestinal obstruction.However,the mechanism of its treatment has not been studied.The bitter taste receptors(T2Rs)are highly expressed in the extra-oral digestive system,such as gastrointestinal tract,which can regulate gastrointestinal peristalsis and contraction of gastrointestinal smooth muscle.In the respiratory system,T2Rs can relax the airway smooth muscle and effectively alleviate asthma symptoms.In this review,the theory and clinical applications of bitter herbs in TMM were discussed and the functional expression of T2Rs and bitter taste signal transduction pathway were analyzed to investigate whether bitter Mongolian medicine may play an effective role in promoting gastrointestinal peristalsis.Therefore,the scientific connotation of the theory of bitter medicinal property of TMM was interpreted by combining T2Rs research and application of modern technology.This new research approach may enrich and improve the basic theory and accelerate the modernization of TMM. | Hong-Zhen Yu Li-Sha A Xiao-Ping Ji Sung-Bo Cho Gen-Na Ba Peng-Fei Han Ming-Hai Fu | 2020 | TMR Theory and Hypothesis2020，3，2： | 3 |
| 13 | The concept of narrative evidence-based medicine and shared decision-making in traditional Chinese medical practice显示文摘随着精准医疗战略的推进,新兴诊断治疗技术的爆发式发展,共同决策可以提高临床决策的质量,促进中医临床研究向证据的转化。关注患者的叙述需求,加强医学人文关怀,可提高临床疗效和患者满意度。本文介绍了循证医学、叙述医学和共同决策的起源和发展,分析了中医临床决策中存在的问题。进一步,在叙述循证医学理念和方法的指导下,提出了临床医师和患者共同决策的方法。 | Wei Mu Hong-Cai Shang Xu-Fang Gu Li Zhang Yan-Fen Li Jie Li Rui-Hua Wang Yu-Hong Huang Bao-He Wang | 2018 | TMR Integrative Medicine2018，2，3： | 3 |
| 14 | Mechanism of cancer-induced fatigue显示文摘Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and powerlessness in both mental and physical aspects.Fatigue related to cancer and cancer treatment will affect the physical and mental health of cancer patients for a long time and continuously,and it is hard to be relieved through rest.Nowadays,most of the researches focus on the clinical manifestations of patients with cancer,such as pain,nausea and vomiting,weight loss and so on.The fatigue feeling of cancer patients is often one of the most easily overlooked pain symptoms in the treatment process.The influence of CRF on cancer patients may be one of the reasons for reducing the survival time of cancer patients.This paper aims to summarize and explore the pathogenesis of cancer-related fatigue,in order to analyze the related factors of cancer-related fatigue from multi-dimensional and multi-angle,and provide reference for its comprehensive treatment in clinic. | Jing-Yu Xu Yi-Hua Fan Jun-Ze Geng Hui-Xin Chen Zi-Jun Qi Xin-Ju Li | 2021 | TMR Cancer2021，4，3： | 3 |
| 15 | 新型冠状病毒所致免疫性肺损害中医治疗的一些思考显示文摘新型冠状病毒所致免疫性肺损害是感染致死的最主要原因。本文强调中医治疗要以“病的人”为着眼点,而不是过多关注致病的病毒。从伤寒与温病汇通的角度入手,讲述了麻黄升麻汤、达原饮、青蒿鳖甲汤的组方思路,并汇通三方,给出了治疗新冠病毒感染所致呼吸困难、舌苔厚腻、反复发热的基本方,为一线战斗的中医工作者提供一些治疗思路和想法。 | 彭涛 贾鲁栋 | 2020 | TMR经典中医研究2020，3，2： | 2 |
| 16 | The inheritance path research of the processing of Chinese materia medica in Anguo herbs market显示文摘Anguo,known as Qizhou in ancient time,its herbs industry began in Song Dynasty,boomed in Ming,and flourished in Qing.During the development of Qizhou herbs industry,a number of special processing techniques of Chinese Materia Medicine were produced.'Qizhou's Four Uniqueness',of which,the most representative medicine includes'Hundred pieces areca','Cicada feather of Qingxia','Yunpian deer antler'and'Pound Rhinoceros unicornis L'.To investigate the present inheritance situation of the traditional processing technology of Chinese Materia Medicine in Anguo herbs market,we will consult literature including the ancient books and records,Anguo local chronicles and visit the inheritors of the traditional processing technology in Anguo,and research the processing technology historical origin.This study aims to create the Anguo herbs cultural card,and enrich the cultural heritage of Chinese medicine industry of Anguo country even Hebei province. | Ying Chen Li-Na Zhang Yu-Hui Ma Miao-Miao Lin Xing Zhang Yu Wang Guo-Wei Zhang | 2019 | TMR Theory and Hypothesis2019，2，1： | 2 |
| 17 | Effects of Astragalus polysaccharide on immune function in B16 melanoma mice显示文摘Objective:To examine the effects of Astragalus polysaccharide on immune function in B16 melanoma mice.Method:Forty male C57BL/6 mice were divided equally into a control group,model group,Astragalus polysaccharide low-dose group,and Astragalus polysaccharide high-dose group,with 10 mice per group.B16 cells were used to develop a mouse model of melanoma.After B16 engraftment,40 mg/kg and 80 mg/kg Astragalus polysaccharide was administered by gavage every day to the Astragalus polysaccharide low-dose group and Astragalus polysaccharide high-dose group,respectively.Splenic index,thymic index,tumor growth curves,and tumor inhibition rates were measured.Flow cytometry was used to measure proportions of peripheral blood T lymphocyte subsets.Hematoxylin and eosin staining was used to examine histopathological changes in tumors.Immunofluorescence double staining was used to identify myeloid-derived suppressor cells in tumor tissues.Results:In the Astragalus polysaccharide high-dose group,splenic and thymic indices were significantly increased and tumor growth was inhibited in melanoma mice.Flow cytometry demonstrated increased CD4^(+)and CD4^(+)/CD8^(+)T-cell ratios in the high-dose Astragalus polysaccharide group.HE staining demonstrated significantly decreased numbers of tumor cells among mice with melanoma in the high-dose Astragalus polysaccharide group.Immunofluorescence double staining demonstrated significantly decreased numbers of myeloid-derived suppressor cells in tumor tissues in the high-dose Astragalus polysaccharide group.Conclusion:Astragalus polysaccharide inhibits tumor growth,increases splenic and thymic indices,increases CD4^(+)and CD4^(+)/CD8^(+)T-cell ratios,and decreases myeloid-derived suppressor cell numbers in melanoma mice.Our results indicate Astragalus polysaccharide may enhance immune function resulting in inhibition of tumorigenesis and tumor progression. | Fang-Hua Wu Kui Chen De-Kun Zhang Chao Gong Jiang-Yue Yu Shen-Zhou Huang Chen-Xin Huang Li-Qun Wang | 2021 | TMR Integrative Medicine2021，5，12： | 2 |
| 18 | Systematic evaluation and trial sequential analysis of warming acupuncture combined with joint mobilization in the treatment of scapulohumeral periarthritis显示文摘Objective:To evaluate the clinical efficacy of warming acupuncture combined with joint mobilization for the treatment of scapulohumeral periarthritis.Methods:A search for published randomized controlled trials(RCT)investigating warming acupuncture combined with joint mobilization for the treatment of scapulohumeral periarthritis was performed using the Cochrane Library,PubMed,Embase,and Web of Science databases.According to requirements of the Cochrane systematic review,all evaluations of RCT investigating warming acupuncture with joint mobilization in the treatment of scapulohumeral periarthritis were performed via method quality assessment,data extraction,and data analysis.Revman 5.3 and Stata 12.0 statistical software were used for the meta-analysis,and the trial sequential analysis(TSA)software estimated the required information size for each outcome.Results:A total of 14 articles were retrieved for meta-analysis,which included 551 cases in the treatment group and 539 cases in the control group.Meta-analysis showed that:(1)warming acupuncture combined with joint mobilization improved total efficiency[OR=6.16,95%CI(3.79,10.00),Z=7.34;P<0.001),TSA results confirmed the results of the meta-analysis;(2)warming acupuncture combined with joint mobilization improved the cure rate[OR=2.84,95%CI(2.19,3.70),P<0.001],TSA results revealed that no further tests were needed to verify;(3)warming acupuncture combined with joint mobilization reduced the number of treatments required for healing[MD=-7.49,95%CI(-9.75,-5.23),P<0.001],TSA results confirmed the results of the meta-analysis;(4)in comparing visual analog scale scores before and after treatment,meta-analysis result showed that:SMD=-2.01,95%CI(-2.37,-1.65),P<0.001,the difference was statistically significant,TSA results confirmed the results of the meta-analysis.Conclusion:Warming acupuncture combined with joint mobilization had a significant effect on the treatment of scapulohumeral periarthritis. | Rong Tian Da Li Yu-Hui Han Yi-Hua Fan | 2018 | TMR Non-Drug Therapy2018，1，3： | 2 |
| 19 | Effect of blood gas analysis in patients with bed rest and blood sampling through the dorsal artery:A meta-analysis显示文摘目的:系统评价经足背动脉采血在卧床患者血气分析中的应用效果。方法:检索PubMed、中国知网、万方数据库及维普数据库中关于经足背动脉采血在血气分析中的应用效果的随机对照试验(RCTs)。2名评价者独立对文献进行检索及筛选、提取相关数据,并对纳入文献的方法学质量进行评价后,采用RevMan5.3软件行Meta分析。结果:最终纳入12项随机对照试验,共计1696例患者。经Meta分析,经足背动脉穿刺使卧床患者动脉穿刺一次成功情况提高[Z=5.78,95%CI(1.90,3.66),P<0.001],减少血肿发生[Z=4.27,95%CI(0.19,0.54),P<0.001],减少误穿静脉的发生[Z=4.60,95%CI(0.08,0.36),P<0.001],减少青紫发生[Z=2.84,95%CI(0.23,0.81),P<0.008]差异均有统计学意义。结论:足背动脉穿刺可以提高对卧床患者动脉穿刺时一次成功的情况,减少血肿、误穿静脉及青紫的发生,可在临床推广。 | Yuan Jia Si-Yuan Yang Li-Ming Guo Qian Wu Fan-Jie Meng | 2019 | TMR Integrative Nursing2019，3，2： | 2 |
| 20 | Analysis of pharmacological action and clinical application of DaXueTeng based on its anti-inflammatory action显示文摘中药大血藤作为清热解毒的代表药物之一,含有多种化学物质例如鞣质、糖苷、环多酚类、三萜皂甙类、木质素类、黄酮类、甙类及有机酸类等,其有广泛的药理作用且受到医家重视.现代研究认为大血藤具有抗菌、抗病毒、抗炎、抗肿瘤、免疫抑制等作用,经实验和临床证明,大血藤的有效成分对炎症疾病有很好的治疗效果.在治疗盆腔炎、附件炎、前列腺炎、阑尾炎、阑尾周围脓肿、炎性肠梗阻、克罗恩氏病、子宫内膜异位症、炎性继发性不孕症、痛风性关节炎、咽喉炎、口腔炎等方面应用广泛.在此我们对大血藤抗炎的药理作用及临床应用方面进行了综述. | Li-hui Zhang Miao-miao Lin Ying Chen Xue-song Wu Li-jing Cai Mei-shan Li Guo-wei Zhang | 2018 | TMR Modern Herbal Medicine2018，1，4： | 2 |
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