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| 1 | Melatonin abates liver ischemia/reperfusion injury by improving the balance between nitric oxide and endothelin显示文摘BACKGROUND: Melatonin exerts complex physiological and pharmacological effects on multiple systems and organs. We hypothesized that melatonin might abate ischemia/ reperfusion (I/R) injury in the liver by inhibiting excessive oxidative stress and keeping nitric oxide (NO) from being scavenged by free radicals. The aim of the present study was to investigate whether melatonin protects the liver from I/R injury and, if so, by what underlying mechanism. METHODS: Under anesthesia, Wistar rats were intraperi- toneally injected with 20 mg/kg melatonin (dissolved in physiological saline containing 4% ethanol, Mel group), 4% alcohol (Alc group), or physiological saline (NS group). The artery, portal vein and bile duct of the left lobe of the liver were clamped for 60 minutes and then released. At different time points after I/R, the rats were sacrificed and blood samples were collected to measure the levels of serum alanine aminotransferase (ALT), lactic dehydrogenase (LDH), and NO. Hepatic tissue samples were collected for measuring endothelin expression by immunohistochemical staining and for routine morphological and histological examination. RESULTS: The levels of both ALT and LDH in the Mel group were significantly reduced for up to 24 hours after I/R compared with the Alc and NS groups (P<0.05). The levels of NO in the Mel group were significantly elevated for up to 12 hours after I/R relative to the NS group (P<0.05). The NO levels were also elevated at 0.5 and 6 hours after I/R in the Alc group (P<0.05). The immunohistochemical staining of hepatic tissue showedthat endothelin-positive cells were significantly fewer in the Mel group than in the Alc and NS groups at 6 hours after I/R (P<0.01). The necrosis of hepatocytes and the destruction of hepatic cords in the Alc and NS groups were greatly improved in Mel-treated rats, which is in concert with our functional data. CONCLUSIONS: Pretreatment with melatonin increased NO bioavailability and decreased endothelin expression, and consequently played a protective role in preserving both liver function and structure during ischemia and reperfusion injury. | Wen-Hai Zhang, Jian-Yi Li and Yong Zhou Department of 5th General Surgery, Second Affiliated Hospital , China Medical University, Shenyang 110004, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 6 |
| 2 | Wave propagation and energy dissipation in viscoelastic granular media显示文摘In terms of viscoelasticity, the relevant theory of wave i n granular media is analyzed in this paper. Under the conditions of slight deforma tion of granules, wave equation, complex number expressions of propagation vecto r and attenuation vector, attenuation coefficient expressions of longitudinal wa ve and transverse wave, etc, are analyzed and deduced. The expressions of attenu ation coefficients of viscoelastic longitudinal wave and transverse wave show th a t the attenuation of wave is related to frequency. The higher the frequency is, the more the attenuation is, which is tested by the laboratory experiment. In a ddi tion, the energy dissipation is related to the higher frequency wave that is abs orbed by granular media. The friction amongst granular media also increase the e nergy dissipation. During the flowing situation the expression of transmission f actor of energy shows that the granular density difference is the key factor whi ch leads to the attenuation of vibrating energy. This has been proved by the exp eriment results. | SUN Ye-zhi 1, WU Ai-xiang 1, LI Jian-hua 1,2 (1. College of Resources, Environment and Civil Engineering, Central South Unive rsity, Changsha 410083, China 2. The 5th Building Company in Guangdong Province, Shaoguan 512026, China) | 2001 | Journal of Central South University2001，13，3： | 2 |
| 3 | Excited response of granular ores in vibrating field显示文摘The dynamical theory was utilized to probe into the law of the excited response of granular ores generated by the exciting action of exciter and the influence of wave propagation in vibrating field. The exciter with double axes was presented as an example, and the principle of exciter and its mathematical expression of the excitation force were given. The granular ores have viscidity and damping speciality, on the basis of which the motion equation of excited response of ores was established and the approximate expression of mode displacement by harmonic excitation and the steady effect solution of coordinate response were deduced. Utilizing the step by step integration method, the recursion relation matrix of displacement, velocity and acceleration of the excited response of ores were obtained, and the computational flow chart and a computational example were given. The results show that the excited response can change the dynamical character and the flowing characteristic of granular ores. | LI Jian hua 1,2 , SUN Ye zhi 1, WU Ai xiang 1, CHEN Shou ru 1 (1.College of Resources, Environment and Civil Engineering, Central South University, Changsha 410083, China 2.The 5th Building Company in Guangdong Province, Shaoguan 512026, C | 2001 | Journal of Central South University of Technology2001，8，2： | 1 |
| 4 | Calciumdependent association of calmodulin with the C-terminal domain of the tetraspanin protein peripherin/rds显示文摘 | Edrington TC 5th Yeagle PL Gretzula CL | 2007 | Biochemistry2007，46，： | 1 |
| 5 | Quantitative and reproducible murine model of excisional wound healing显示文摘 | Galiano RD Michaels J 5th Dobryansky M | | 0，，04： | 1 |
| 6 | The alpha 2-adrenergic agonistsclonidine and guanfacine produce tonic and phasic block of con-duction in rat sciatic nerve fibers显示文摘 | Butterworth JF 5th Strichartz GR | 1993 | Anesth Analg1993，76，2： | 1 |
| 7 | The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers显示文摘 | Butterworth JF 5th Strichartz GR | 1993 | Anesth Analg1993，76，2： | 1 |
| 8 | The alpha 2 - adrenergic agonists clonidine and guanfaeine produce tonic and phasic block of conduction in rat sciatic nerve fibers 显示文摘 | Butterworth JF 5th Strichartz G R | 1993 | Anesth Analg1993，76，2： | 1 |
| 9 | Quantitative and reproducible murine model of excisional wound healing 显示文摘 | Galiano RD Michaels J 5th Dobryansky M | 2004 | Wound Repair Regen2004，12，4： | 1 |
| 10 | Complications in posthariatric body contouring: strategies for assessment and prevention显示文摘 | MichaelsJ 5th Coon D RubinJP | 2011 | Plast Reconstr Surg2011，127，3： | 1 |
| 11 | Hypothermia and complications in postbariatric body contouring显示文摘 | Coon D MichaelsJ 5th GusenoffJA | 2012 | Plast Reconstr Surg2012，130，44： | 1 |
| 12 | Does contribute early enteral nutrition to decrease the complications of radical gastrectomy for gastric cancer显示文摘 | DELGADO DELGADO RC LUQUE VASQUEz CE 5th | 2011 | Rev Gastroenterol Peru2011，31，2： | 1 |
| 13 | The effect of background music on the perceptionof personality and demographics 显示文摘 | Lastinger DL 5th | 2011 | J Music Ther2011，48，2： | 1 |
| 14 | Muhiple procedures and staging in the massive weight loss population 显示文摘 | Coon D Michaels J 5th Gusenoff JA | 2010 | Plast Reconstr Surg2010，125，2： | 1 |
| 15 | The alpha 2-adrenergie agonists clunidine and guanfacine produce tonic and phasic block of conduc- tion in rat sciatic nerve fibers 显示文摘 | Butterworth JF 5th Strichartz GR | 1993 | Anesth Analg1993，76，2： | 1 |
| 16 | 超体质量减肥手术后体形塑造术的低体温症和并发症显示文摘背景超体质量减肥手术后的体形塑造是一个迅速增长的领域。因为手术时间长和轻度并发症发生率较高,需要循证医学指导手术管理。目前,关于围手术期因素对患者结果影响的数据分析很有限。方法纳入体质量减轻50磅以上,且行体形塑造术的患者。所有手术均由资深专家进行, | Devin Coon Joseph Michaels 5th Jeffrey A. Gusenoff Tae Chong Chad Purnell J. Peter Rubin 朱丽娜(译) 魏峰(译) 高景恒(译) 张晨(译) | 2013 | 中国美容整形外科杂志2013，24，7： | 0 |
| 17 | The Gain Dependence of the Power Transient in Raman Amplifier显示文摘It is observed that the amplitude of the power transient overshoot depends on the gain of the amplifier when the input signal powers are the same. The other system parameters, such as the input pump power and fiber length, have no effects on it. | Zheng Lei, Zhang Jiahong, Chen Zhangyuan, Wu Deming , Xu AnshiNational Laboratory on Local Fiber-Optic Networks and Advanced Optical Communication Systems, Electronics Department, Peking University, Beijing 100871, China, Tel: 86-010- 62763334, Email: zheng_lei@ele.pku.edu.cn Zhang Jiahong is with the 5th Institute of Telecommunications Technology of Ministry of Information Industry (MII, and Datang telecom technology Co., Ltd, Opitcal Communication Branch, Chengdu 610062, China | 2003 | 光学学报2003，23，S1： | 0 |
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