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951篇 您的检索式：作者名="A Hardy"

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	题名	作者	年代	出处	被引量
1	Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma显示文摘AIM: To characterise expression of known E-cadherin repressors; Snail, Slug and Twist in the development of esophageal adenocarcinoma. METHODS: E-cadherin, Slug, Snail and Twist mRNA expression in Barrett's metaplasia and esophageal adenocarcinoma specimens was examined by real-time reverse transcription-polymerase chain reaction (RT-PCR). Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein levels. The effect of Slug on epithelial mesenchymal transition (EMT) markers was examined by transfection of Slug into an adenocarcinoma line OE33.RESULTS: Cellular localisation of Slug in Barrett's metaplasia was largely cytoplasmic whilst in adenocarcinoma it was nuclear. Semi-quantitative analysis indicated that Slug was more abundant in adenocarcinoma compared to matched Barrett's metaplastic specimens. Snail and Twist were expressed in adenocarcinoma but were cytoplasmic in location and not induced compared to Barrett's mucosa. These observations were supported by mRNA studies where only Slug mRNA was shown to be over-expressed in adenocarcinoma and inversely correlated to E-cadherin expression. Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin.CONCLUSION: Progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing.	Paras Jethwa Mushal Naqvi Robert G Hardy Neil A Hotchin Sally Roberts Robert Spychal Chris Tselepis	2008	World Journal of Gastroenterology2008，14，7：	24
2	Response of continuous pave-ments to moving dynamic loads显示文摘	Cebon D	1993	Journal of Engineering Mechanics American Society of Civil Engineering1993，119，9：	1
3	The dietary energy values of soya-bean oil, tallow and their blends for growing/finishing pigs显示文摘	WISEMAN J COLE D J A HARDY B	1990	Animal Production1990，50，3：	1
4	Acid and bile salts induce DNA damage in human oesophageal cell lines显示文摘	JELLY A J WILD C P HARDIE L J	2004	Mutagenesis2004，19，4：	1
5	Simple and efficient decoupling in magic-angle spinning solid-state NMR: the XiX scheme显示文摘	Detken A Hardy E H Ernst M	2002	Chem Phys Lett2002，356，34：	1
6	Scene-based nonuniformity correction technique that exploits knowledge of the focal-plane array readout architecture显示文摘	Narayanan B Hardie R C Muse R A	2005	Applied Optics2005，44，17：	1
7	Response of continuous pavements to moving dynamic loads 显示文摘	Hardy M S A Cebon D	1993	Journal of Engineering Mechanics1993，119，9：	1
8	Railway vehicle internal noise显示文摘	EADE P W HARDY A E J	1977	Journal of Sound and Vibration1977，51，3：	1
9	Characteristics Of A Widespread Community Cluster of H275Y Oseltamivir-resistant A(H1N1)pdm09Influenza In Australia显示文摘	Hurt A C Hardie K Wilson N J	2012	Journal of Infectious Diseases2012，206，2：	1
10	AMPK:a nutrient and energy sensor that maintains energy homeostasis显示文摘	HARDIE D G ROSS F A HAWLEY S A	2012	Nature Reviews Molecular Cell Biology2012，13，4：	1
11	Gas dispersion properties: Bubble surface area flux and gas holdup 显示文摘	Finch J A Xiao J Hardie C	2000	Mineral Engineering2000，，4：	1
12	Purification and biological activity of thymosin,a hormone of the thymus gland显示文摘	GOLDSTEIN A L GUHA A HARDY M A	1972	Proceedings of the Natio-nal Academy of Sciences of the United States of America1972，69，7：	1
13	Dolomitization front geometry,fluid flow patterns and the origin of massive dolomite 显示文摘	Wilson E N Hardie L A Phillips O M	1990	America Journal of Science1990，290，5：	1
14	Peptide-binding heat shock protein GRP78 protects cardiomyocytes from hypoxia-induced apoptosis 显示文摘	Hardy B Raiter A	2010	JMol Med-Jmm2010，88，11：	1
15	Activating gene expression in mammalian cells with promoter-targeted duplex RNAs显示文摘	Janowski B A Younger S T Hardy D B	2007	Nat Chem Biol2007，3，3：	1
16	Genome wide association studies and human disease显示文摘	Hardy J Singleton A	2009	N Engl J Med2009，360，：	1
17	Les hexacyano- ferrates zeolithiques: structure cristalline de K2Zn: 2 xH20显示文摘	Gravereau P Garnier E Hardy A	1979	Acta Cryst Section B Struct Crystal Chem1979，35，12：	1
18	Management and outcome of cats with ureteral calculi:153 cases(1984-2002)显示文摘	Kyles A E Hardie E M Wooden B G	2005	J Am Vet Med Assoc2005，226，：	1
19	AMP-activated protein kinase - -a sensor of glycogen as well as AMP andATP? 显示文摘	MCBRIDE A HARDIE DG	2009	Acta Physiol (Oxf)2009，196，1：	1
20	Value to patients of a breast cancer clinical nurse specialist 显示文摘	Hardie H Leary A	2010	Nurs Stand2010，24，34：	1

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