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| 1 | Current scenario of traditional medicines in management of diabetic foot ulcers:A review显示文摘Diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often recurring.DFU have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound healing.DFU have been the leading cause for non-traumatic amputations of part or whole of the limb.Western medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading techniques.Advances in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in amputations.However,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing nations.This process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without recurrence.Wound modulation with various dressings and techniques are often a costly affair.Some aspects of the topical therapy with modern/Western medicines are frequently not addressed.Cost of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/relevance.Traditional Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood circulation.Traditional medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound healing.There is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic concerns.Various natural and plant derived products(e.g.,honey,aloe vera,oils,and calendula)and maggots are also used for wound healing purposes.We believe that patients with a chronic wound are so tired physically,emotionally,and financially that they usually accept native traditional medicine which has the same cultural base,belief,and faith.Many of these products have never been tested in accordance to“evidence-based medicine.”There are usually case reports and experience-based reports about these products.Recently,there have been some trials(in vitro and in vivo)to verify the claims of usage of traditional medicines in management of DFU.Such studies show that these natural products enhance the healing process by controlling infection,stimulating granulation tissue,antimicrobial action,promoting fibroblastic activity and collagen deposition,etc.In this review,we attempt to study and analyse the available literature on results of topical traditional medicines,which are usually advocated in the management of DFU.An integrated and‘holistic’approach of both modern and traditional medicine may be more acceptable to the patient,cost effective,and easy to administer and monitor.This may also nevertheless lead to further improvement in quality of life and decrease in the rates of amputations for DFU. | Abhijit S Rayate Basavraj S Nagoba Sachin S Mumbre Hardi B Mavani Ajay M Gavkare Advait S Deshpande | 2023 | World Journal of Diabetes2023,14,1: | 3 |
| 2 | The dietary energy values of soya-bean oil, tallow and their blends for growing/finishing pigs显示文摘 | WISEMAN J COLE D J A HARDY B | 1990 | Animal Production1990,50,3: | 1 |
| 3 | Scene-based nonuniformity correction technique that exploits knowledge of the focal-plane array readout architecture显示文摘 | Narayanan B Hardie R C Muse R A | 2005 | Applied Optics2005,44,17: | 1 |
| 4 | New perspectives on cus- tomer 'Death' using a generalization of the Pareto/NBD mod- el显示文摘 | Jerath K Fader P S Hardie B G S | 2011 | Marketing Science2011,30,5: | 1 |
| 5 | Peptide-binding heat shock protein GRP78 protects cardiomyocytes from hypoxia-induced apoptosis 显示文摘 | Hardy B Raiter A | 2010 | JMol Med-Jmm2010,88,11: | 1 |
| 6 | Activating gene expression in mammalian cells with promoter-targeted duplex RNAs显示文摘 | Janowski B A Younger S T Hardy D B | 2007 | Nat Chem Biol2007,3,3: | 1 |
| 7 | Management and outcome of cats with ureteral calculi:153 cases(1984-2002)显示文摘 | Kyles A E Hardie E M Wooden B G | 2005 | J Am Vet Med Assoc2005,226,: | 1 |
| 8 | Surgical management of traumatic posterior urethral strictures in children显示文摘 | PRITCHETT T R SHAPIRO R A HARDY B E | 1993 | Urology1993,42,1: | 1 |
| 9 | Scene based nonuniformity correction with reduced ghosting using a gated LMS algorithm显示文摘 | Hardie R Baxley F Brys B | 2009 | Optics Express2009,17,14: | 1 |
| 10 | Customer-base anal- ysis in a discrete-time noncontractual setting 显示文摘 | Fader P S Hardie B G S Shang Jen | 2010 | Market- ing Science2010,29,6: | 1 |
| 11 | X-ray crys- tallographic structure of the Norwalk virus capsid显示文摘 | Prasad B V Hardy M E Dokland T | 1999 | Science1999,286,5438: | 1 |
| 12 | Marketing-mix variables and the diffusion of successive generations of a technological innovation显示文摘 | Danaher J D Hardie B G | 2001 | Journal of Marketing Research2001,38,: | 1 |
| 13 | Modelling tropical cyclone over-water wind and pressure fields 显示文摘 | McConochie J D Hardy T A Mason L B | 2004 | Ocean Engineering2004,31,13: | 1 |
| 14 | An algebraic algorithm for nonuniformity correction in focal-plane arrays 显示文摘 | Ratliff B M Hayat M M Hardie R C | 2002 | J Opt Soc Am A2002,19,9: | 1 |
| 15 | On the surface free energy of PVC/EVA polymer blends:Comparison of different calculation methods显示文摘 | Michalski M C Hardy J Saramago B J V | 1998 | Journal of Colloid and Interface Science1998,208,1: | 1 |
| 16 | The role of nutrition crowding and interspecific interaction in the development of winged aphid显示文摘 | Muller C B Wiliams I S Hardie J M | 2001 | Environmental Entomology2001,26,: | 1 |
| 17 | Resource, knowledge and influence, the organizational effects of inter-organizational collaboration 显示文摘 | HARDY C PHILLIPS N LAWRENCE T B | 2003 | Journal of Management Studies2003,40,2: | 1 |
| 18 | Anti-mullerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries显示文摘 | Stubbs S A Hardy K Silva B P D | 2005 | The Journal of Clinical Endocrinology Metabolism2005,90,10: | 1 |
| 19 | Institutional effecta of interorganizational collaboration:the emergence of proto-institutions显示文摘 | Lawrence T B Hardy C Philips N | 2002 | Academy of Management Journal2002,45,1: | 1 |
| 20 | The first carbonate field application of a new organically cross-linked water shut-off polymer system显示文摘 | Hardy B R Botermans H W Hamouda A | 1999 | SPE1999,50,738: | 1 |