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| 1 | 凝血酶受体活化与血小板膜糖蛋白Ⅰ bα的异位分布机制显示文摘目的 检测凝血酶受体活化过程中血小板膜糖蛋白 (GP)Ⅰbα的动态分布及其细胞骨架蛋白的改变,揭示GPⅠbα的异位分布机制与凝血酶受体在血小板信号传递中的作用。方法 以凝血酶受体活化肽 (thrombinreceptoractivatingpeptide,TRAP)诱导血小板活化,应用流式细胞术比较刺激前后血小板膜表面GPⅠbα及P 选择素的表达,并通过转移电泳及免疫沉淀技术,分析细胞骨架中GPⅠbα、肌动蛋白、肌球蛋白的变化。观测细胞松弛素 (Cytochalasin) D与腺苷三磷酸双磷酸酶(Apyrase)Ⅶ对血小板活化过程的影响。结果 TRAP作用后促使血小板活化,流式细胞术检测结果显示其P 选择素水平显著升高,而GPⅠbα先呈现进行性减少,而后逐渐回升的可逆性变化。抑制剂作用后这一过程受到不同程度影响,其中细胞松弛素D能阻滞GPⅠbα的内移, ApyraseⅦ对活化过程中GPⅠbα的逆转没有影响,只对它的恢复起作用,促使GPⅠbα迅速返回细胞表面。细胞骨架蛋白分析结果也表明肌动蛋白、肌球蛋白与GPⅠbα受刺激后呈先增加后减少的动态变化趋势。细胞松弛素D能阻滞GPⅠbα、肌动蛋白与肌球蛋白向骨架中心的转位, ApyraseⅦ则能加快骨架蛋白在骨架中心的消散。免疫印迹证实GPⅠbα的这种可逆性变化与血小板膜骨架紧密相关。 | 韩悦 JM Pasquet A Nurden 王兆钺 阮长耿 | 2005 | 中华血液学杂志2005，26，3： | 3 |
| 2 | Plateletactivation in thrombotic disorders显示文摘 | Nurden A KleneW MuttadaL | 1993 | New Rev FrHemsto1993，1，： | 1 |
| 3 | New insights into and novel applications for platelet - rich fibrin therapies显示文摘 | A NITUA E SANCHEZ M NURDEN A T | 2006 | Trends Biotechnol2006，24，5： | 1 |
| 4 | New insights into and novel applications for platelet-rich fibrin therapies显示文摘 | Anitua E Sanchez M Nurden A T | 2006 | Trends Biotechnol2006，24，5： | 1 |
| 5 | Confirmation that GP Ib - IX complexes have a reduced surface distribution on platelets activated by thrombin and TRAP - 142 - mer peptide 显示文摘 | Nurden A Cazes E Bihour C | 1995 | Br J Haematol1995，90，3： | 1 |
| 6 | Platelet acti- vation in thrombotic disorders显示文摘 | NURDEN A T BIHOUR C MACCHI L | 1993 | Nouv Rev Fr Hematol1993，35，11： | 1 |
| 7 | Platelet-released growth fac-tors enhance the secretion of hyaluronic acid and induce hepatocytegrowth factor production by synovial fibroblasts from arthritic pa-tients 显示文摘 | Anitua E Sanchez M Nurden A T | 2011 | Rheumatology2011，46，5： | 1 |
| 8 | Platelet activation in thrombotic disorders显示文摘 | Nurden A Klene W Muttada L | 1993 | New Rev Fr Hemstol1993，，： | 1 |
| 9 | Clopidogrel: a review of its mechanismof action 显示文摘 | Savi P Nurden P Nurden A T | 1998 | Platelets1998，9，34： | 1 |
| 10 | New - generation drugs that stimulate platelet production in chronie immune thrnm- bocytopenic purpura 显示文摘 | NURDEN A T VIALLARD J F NURDEN P | 2009 | Lancet2009，373，9674： | 1 |
| 11 | New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura显示文摘 | Nurden A T Viallard J F Nurden P | 2009 | Lancet2009，373，9674： | 1 |
| 12 | Confirmation that GP Ⅰ b-Ⅸ complexes have a reduced surface distribution on platelets activated by thrombin and TRAP-14-mer peptide显示文摘 | Nurden A Cazes E Bihour C | 1995 | Br J Haematol1995，90，3： | 1 |
| 13 | Platelets, inflammation and tissue regeneration显示文摘 | Nurden A T | 2011 | T h r o m b H a e m o s t2011，105，1： | 1 |
| 14 | Are patients with Glanzmann thrombasthenia and the Bernard-Soulier syndrome protected against atherosclerosis显示文摘 | A T Nurden P Nurden J N George | 2001 | Advances in experinaental medicine and biology2001，489，： | 1 |
| 15 | New-generation drugs that stimulate latelet production in chronic immune thrombocytopenic purpura显示文摘 | NURDEN A T VIALLARD J F NURDEN P | 2009 | Lancet2009，373，： | 1 |
| 16 | A case ofprofound and prolonged tirofiban-induced thrombocytopeniaand its correction by intravenous immunoglobulin G 显示文摘 | Clofent-Sanchez G Harizi H Nurden A | 2007 | JThromb Haemost2007，5，5： | 1 |
| 17 | New insights into and novel applications for platelet - rich fibrin therapies 显示文摘 | ANITUA E SANCHEZ M NURDEN A T | 2006 | Trends Biotechnol2006，24，5： | 1 |
| 18 | Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells 显示文摘 | Anitua E Sanchez M Nurden A T el al | 2007 | Plast Reconstr Surg2007，119，3： | 1 |
| 19 | New insights intl and novel applications for platelet-rich fibrin therapies显示文摘 | A nitua E Sanchez M Nurden AT | 2006 | Trends Biotechnol2006，24，5： | 1 |
| 20 | Platelet activation in thrombotic disorders显示文摘 | Nurden A Klene W Muttada L | 1993 | New Rev Fr Hemstol1993，，： | 1 |
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