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| 1 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 2 | Direct characterization of a nonlinear photonic circuit’s wave function with laser light显示文摘Integrated photonics is a leading platform for quantum technologies including nonclassical state generation1–4,demonstration of quantum computational complexity5 and secure quantum communications6.As photonic circuits grow in complexity,full quantum tomography becomes impractical,and therefore an efficient method for their characterization7,8 is essential.Here we propose and demonstrate a fast,reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit.By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light,we overcome the limitations of previous approaches for lossy multimode devices9,10.We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31%fidelity between classical and quantum characterization.This technique enables fast and precise evaluation of nonlinear quantum photonic networks,a crucial step towards complex,largescale,device production. | Francesco Lenzini Alexander N Poddubny James Titchener Paul Fisher Andreas Boes Sachin Kasture Ben Haylock Matteo Villa Arnan Mitchell Alexander S Solntsev Andrey A Sukhorukov Mirko Lobino | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 3 | E6 molecular variants of human papillomavirus (HPV) type 16: An updated and unified criterion for clustering and nomenclature显示文摘 | Antonio Huertas-Salgado Diana C. Martín-Gámez Pablo Moreno Raúl Murillo María Mercedes Bravo Luisa Villa Mónica Molano | 2010 | Virology2010，，： | 2 |
| 4 | Intracellular Ca^2+ stores in chicken Purkinje neurons: differential distribution of the low affinity-higih capacity Ca^2+ -binding protein, calsequestrin of Ca^2+ -ATPase and of the ER Luminal protein 显示文摘 | Villa A Podine P Clegg D O | 1991 | Cell Biology1991，113，： | 1 |
| 5 | Variant liver estrogen receptor transcripts already occur at an early stage of chronic liver disease 显示文摘 | Villa E Dugani A Moles A | 1998 | Hepatology1998，27，4： | 1 |
| 6 | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors,atorvastatin and simvastatin,induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation显示文摘 | Blanco-Colio LM Villa A Ortego M | 2002 | Atherosclerosis2002，161，： | 1 |
| 7 | Prognostic implication of clinical,radiologic, and pathologic features in patients with anaplastic gliomas显示文摘 | Tortosa A Vinolas N Villa S | 2003 | Cancer2003，97，4： | 1 |
| 8 | The genetic and biochemical basis of Omenn syndrome显示文摘 | Santagata S Villa A Sobacchi C | 2000 | Immunol Rev2000，178，： | 1 |
| 9 | CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway显示文摘 | Villa I Mrak E Rubinacci A | | 0，，03： | 1 |
| 10 | The use of VR in the treatment of panic disorders and agoraphobia显示文摘 | Botella C Villa H García Palacios A | | 0，，： | 1 |
| 11 | Single drop microextraction and gas chromatography–mass spectrometry for the determination of diflufenican, mepanipyrim, fipronil, and pretilachlor in water samples显示文摘 | Lilia Araujo María E. Troconis Dalia Cubillán Jair Mercado Noreiva Villa Avismelsi Prieto | 2013 | Environmental Monitoring and Assessment2013，，12： | 1 |
| 12 | Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs 显示文摘 | Bragonzi A Dina G Villa A | 2000 | Gene Ther2000，7，20： | 1 |
| 13 | Variability of anthropogenic and natural compounds in high altitude-high accumulation alpine glaciers 显示文摘 | Maggi V Villa S Finizio A | 2006 | Hydrobiologia2006，562，： | 1 |
| 14 | Selective uterine artery embolization: a new therapeutic approach in a patient with low-risk gestational trophoblastic disease 显示文摘 | Carlini L Villa A Busci L | 2006 | Am J Obstet Gynecol2006，195，1： | 1 |
| 15 | Complement C5 mediates experimental tubulointerstitial fibrosis显示文摘 | BOOR P KONIECZNY A VILLA L | 2007 | J Am Soc Nephrol2007，18，5： | 1 |
| 16 | Successful treatment of extramammary Paget's disease of the scrotum with imiquimod 5% cream显示文摘 | Berman B Spencer J Villa A | 2003 | Clin Exp Dermatol2003，281，： | 1 |
| 17 | ABO genotyping in Italian blood donors显示文摘 | Villa A Drago F Misto R | 1996 | Haematologica1996，81，6： | 1 |
| 18 | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors,atorvastatin and simvastatin,induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation显示文摘 | BLANCO-COLIO LM VILLA A ORTEGO M | 2002 | Atherosclerosis2002，161，1： | 1 |
| 19 | How does GAP catalyze the GTPase react of Ras? A computer simulation study显示文摘 | Glennon TM Villa J Warshel A | 2000 | Biochemistry2000，39，32： | 1 |
| 20 | Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen fol- lowed by two different radiotherapy treatments 显示文摘 | Bessell EM Lopez-Guillermo A Villa S | 2002 | J Clin Oncol2002，20，： | 1 |
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