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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | Targeting Wnt/β-catenin pathway in hepatocellularcarcinoma treatment显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Liver cancer is generally related to hepatitis B or Cinfection and cirrhosis. Usually, patients with HCC are asymptomatic and are diagnosed at late stages when surgical treatment is no longer suitable. Limited treatment options for patients with advanced HCC are a major concern. Therefore, there is an urge for finding novel therapies to treat HCC. Liver cancer is highly heterogeneous and involved deregulation of several signaling pathways. Wnt/β-catenin pathway is frequently upregulated in HCC and it is implicated in maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. A great effort in developing selective drugs to target components of the β-catenin pathway with anticancer activity is underway but only a few of them have reached phase Ⅰ clinical trials. We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance. We also evaluated the use of small molecules targeting the Wnt/β-catenin pathway with potential application for treatment of HCC. | valery vilchez lilia turcios francesc marti roberto gedaly | 2016 | World Journal of Gastroenterology2016，22，2： | 51 |
| 3 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 4 | Epilepsy associated tumors: Review article显示文摘Long-term epilepsy associated tumors(LEAT) represent a well known cause of focal epilepsies. Glioneuronaltumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly ariseing in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic networkwith complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation. | Marco Giulioni Gianluca Marucci Matteo Martinoni Anna Federica Marliani Francesco Toni Fiorina Bartiromo Lilia Volpi Patrizia Riguzzi Francesca Bisulli Ilaria Naldi Roberto Michelucci Agostino Baruzzi Paolo Tinuper Guido Rubboli | 2014 | World Journal of Clinical Cases2014，2，11： | 9 |
| 5 | Molecular analysis of hepatitis B virus isolates in Mexico:Predominant circulation of hepatitis B virus genotype H显示文摘AIM: To determine the genotypes in Mexican hepatitis Bvirus (HBV) isolates and characterize their precore andcore promoter mutations.METHODS: Forty-nine HBV isolates of Mexico obtainedfrom sera of 15 hepatitis patients, 6 hemodialysis pa-tients, 20 men seeking HIV testing, and 8 AIDS patientswere analyzed. HBV isolates were amplified by PCR,and genotyped by line probe assay (INNO-LiPA HBVGenotyping; INNOGENETICS N V, Ghent, Belgium).HBV genotype confirmation was performed by DNAsequencing part of the sAg region. Precore and core pro-moter mutation characterization was performed by lineprobe assay (INNO-LiPA HBV PreCore; INNOGENETICS NV, Ghent, Belgium).RESULTS: Overall, HBV genotype H was found in 37(75.5%) out of the 49 isolates studied. HBV genotypesG, A, and D were found in 5 (10.2%), 4 (8.2%), and 3(6.1%) isolates, respectively. HBV genotype H was pre-dominant in isolates from hemodialysis patients (100%),hepatitis patients (80%), and men seeking HIV test-ing (75%), and accounted for half of infections in AIDSpatients (50%). Six (12.2%) out of the 49 HBV isolatesshowed both wild type and mutant populations at pre-core codon 28. These mixed wild type and precore mu-tant populations were observed in one HBV genotype Aisolate and in all HBV genotype G isolates. A dual variantcore promoter mutation was observed in 1 (2%) of theisolates, which was genotype H.CONCLUSION: HBV genotype H is highly predominantin HBV isolates of Mexico followed by genotypes G, Aand D. A low frequency of precore and core promotermutations is observed in HBV Mexican isolates. | Cosme Alvarado-Esquivel Erwin Sablon Carlos Jesús Conde-GonzálezNational Institute of Public Health Cuernavaca Morelos Mexico Luis Juárez-Figueroa Lilia Ruiz-Maya Sergio-Aguilar Benavides | 2006 | World Journal of Gastroenterology2006，12，40： | 6 |
| 6 | Genetic Diversity and Association Analysis for Salinity Tolerance, Heading Date and Plant Height of Barley Germplasm Using Simple Sequence Repeat Markers显示文摘The objective of this study was to investigate the genetic diversity of barley accessions. Additionally, association trait analysis was conducted for grain yield under salinity, heading date and plant height. For this purpose, 48 barley genotypes were analyzed with 22 microsatellite simple sequence repeat (SSR) markers. Four of the 22 markers (Bmac316, scssr03907, HVM67 and Bmag770) were able to differentiate all barley genotypes. Cluster and principal coordinate analysis allowed a clear grouping between countries from the same region. The genotypes used in this study have been evaluated for agronomic performance in different environments. Conducting association analysis for grain yield under salinity conditions using TASSEL software revealed a close association of the marker Bmag749 (2H, bin 13) in two different environments with common significant alleles (175, 177), whereas the HVHOTR1 marker (2H, bin 3) was only significant in Sakhar_Egypt with alleles size being 158 and 161. Heading date also showed an association with scssr03907 through the common significant specific allele 111 and EBmac0415 markers in three different agro climatic locations, whereas HVCMA, scssr00103 and HVM67 were linked to heading date in the Egyptian environment only. The plant height association analysis revealed significant markers Bmag770 via the significant allele 152 and scssr09398. | Lilia Eleuch Abderrazek Jilal Stefania Grando Salvatore Ceccarelli Maria von Korff Schmising Hisashi Tsujimoto Amara Hajer Abderrazek Daaloul Michael Baum | 2008 | Journal of Integrative Plant Biology2008，50，8： | 5 |
| 7 | TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis显示文摘 | Charles Thomas Antimo Gioiello Lilia Noriega Axelle Strehle Julien Oury Giovanni Rizzo Antonio Macchiarulo Hiroyasu Yamamoto Chikage Mataki Mark Pruzanski Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2009 | Cell Metabolism2009，，3： | 4 |
| 8 | Neural plasticity and adult neurogenesis: the deep biology perspective显示文摘The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology. | Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina Michele Papa Hans V.Westerhoff | 2019 | Neural Regeneration Research2019，14，2： | 3 |
| 9 | Role of Nitrogen and Nutrients in Crop Nutrition显示文摘 | Vicente Torres-Olivar Oscar Gabriel Villegas-Torres Martha Lilia Dominguez-Patifio Hoctor Sotelo-Nava Antonio Rodrlguez-Martme Rosa Maria Melgoza-Aleman Luis Alonso Valdez-Aguilar Irfin Alia-Tejacal | 2014 | Journal of Agricultural Science and Technology(B)2014，4，1： | 3 |
| 10 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 11 | Anthropometric study of Mexican primary school children显示文摘 | Lilia R Prado-León Rosal??o Avila-Chaurand Elvia L González-Mu?oz | 2001 | Applied Ergonomics2001，，4： | 2 |
| 12 | Murine models based on acute myeloid leukemia-initiating stem cells xenografting显示文摘Acute myeloid leukemia(AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells(LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells. Animal models provides the means to investigate the factors responsible for leukemic transformation, the intrinsic differences between secondary post-myeloproliferative neoplasm AML and de novo AML, especially the signaling pathways involved in inflammation and hematopoiesis. However, AML proved to be one of the hematological malignancies that is difficult to engraft even in the most immunodeficient mice strains, and numerous ongoing attempts are focused to develop 'humanized mice' that can support the engraftment of LSC. This present review is aiming to in-troduce the field of AML pathogenesis and the concept of LSC, to present the current knowledge on leukemic blasts surface markers and recent attempts to develop best AML animal models. | Cristina Mambet Mihaela Chivu-Economescu Lilia Matei Laura Georgiana Necula Denisa Laura Dragu Coralia Bleotu Carmen Cristina Diaconu | 2018 | World Journal of Stem Cells2018，10，6： | 2 |
| 13 | An overview of forensic operations performed following the terrorist attacks on November 13,2015,in Paris显示文摘On the evening of November 13,2015,the city of Paris and its surroundings was hit by a series of attacks committed by terrorist groups,using firearms and explosives.The final toll was 140 people deceased(130 victims and 10 terrorists or their relatives)and more than 413 injured,making these attacks the worst mass killings ever recorded in Paris in peacetime.This article presents the forensic operations carried out at the Medicolegal Institute of Paris(MLIP)following these attacks.A total of 68 autopsies of bodies or body fragments and 83 external examinations were performed within 7 days,and the overall forensic operations(including formal identification of the latest victims)were completed 10 days after the attacks.Over this period,156 body presentations(some bodies were presented several times)were provided to families or relatives.Regarding the 130 civilian casualties,129 died from firearm wounds and one died from blast injuries after an explosion.Of the 10 terrorists or their relatives who were killed,eight died from suicide bombing,one was shot by police and one died from crush injuries due to partial collapse of a building following the police raid against a terrorist’s hideout after the attacks.All mass shootings were perpetrated with AK-47 or Zastava M70 assault rifles using 7.62mm39mm cartridges.In the case of ballistic injuries,death was most often obviously caused by craniocerebral injuries,extensive organ lacerations and/or massive haemorrhage.Among the terrorists killed by bombing,the lesion patterns were body transection,multiple amputations,extreme organ lacerations and the presence of foreign bodies owing to the shrapnel load(steel nuts,glass fragments)or the explosive charge fastening system of the devices.This discussion highlights the particular difficulties of interpretation encountered within the framework of ballistic injuries,a conclusion that should lead to a modest and realistic approach in these exceptional situations where forensic operations involve a very large number of victims in a constrained time. | Antoine Tracqui Celine Deguette Tania Delabarde Yann Delannoy Isabelle Plu Isabelle Sec Lilia Hamza Marc Taccoen Bertrand Ludes | 2020 | Forensic Sciences Research2020，5，3： | 2 |
| 14 | Experience with postmortem computed tomography in the forensic analysis of the November 2015 Paris attacks显示文摘Several reports discuss the added value of postmortem computed tomography(PMCT)in the forensic analysis of mass fatality incidents(MFIs),such as the 2009 Victorian bushfires,the Grenfell tower disaster and the MH17 plane crash[1–5].In France,the first deployment of PMCT in an MFI took place during the forensic analysis of the November 2015 Paris terrorist attacks. | Laura W.de Jong Laurence Legrand Tania Delabarde Ghazi Hmeydia Myriam Edjlali Lilia Hamza Joseph Benzakoun Catherine Oppenheim Bertrand Ludes Jean-Francois Meder | 2020 | Forensic Sciences Research2020，5，3： | 2 |
| 15 | Phase Ⅱ, Randomized, Double - Blind, Placebo - Controlled study of recombinant human intestinal trefoil factor oral spray for prevention of oral mucositis in patients with color- ectal cancer who are receiving fluoroutacil - based chemo- therapy显示文摘 | DOUGLAS E P NICHOLAS P B LILIA I A | 2009 | J Clin Oncol2009，27，： | 1 |
| 16 | Single drop microextraction and gas chromatography–mass spectrometry for the determination of diflufenican, mepanipyrim, fipronil, and pretilachlor in water samples显示文摘 | Lilia Araujo María E. Troconis Dalia Cubillán Jair Mercado Noreiva Villa Avismelsi Prieto | 2013 | Environmental Monitoring and Assessment2013，，12： | 1 |
| 17 | Nuclear co-expression of p14 ^{ARF} and p16 ^{INK4A} in uterine cervical cancer-derived cell lines containing HPV显示文摘 | Salvador Vázquez-Vega Lilia Patricia Sánchez-Suárez Adriana Contreras-Paredes Emilio Castellanos-Juárez Rubicelia Pe?arroja-Flores Marcela Lizano-Soberón Rafael Andrade-Cruz Alejandro García-Carrancá Luis Benítez-Bribiesca | 2010 | Cancer Biomarkers2010，，6： | 1 |
| 18 | End-point limiting-dilution real-time PCR assay for evaluation of hepatitis C virus quasispecies in serum: Performance under optimal and suboptimal conditions显示文摘 | Sumathi Ramachandran Guo-liang Xia Lilia M. Ganova-Raeva Omana V. Nainan Yury Khudyakov | 2008 | Journal of Virological Methods2008，，2： | 1 |
| 19 | Libraries 'like to move it, move it' 显示文摘 | Lilia Murray | 2010 | Reference Service Review2010，，2： | 1 |
| 20 | Microbial production of ellagic acid and biodegradation of ellagitannins显示文摘 | Antonio Aguilera-Carbo Christopher Augur Lilia A. Prado-Barragan Ernesto Favela-Torres Cristóbal N. Aguilar | 2008 | Applied Microbiology and Biotechnology2008，，2： | 1 |
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