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| 1 | 硬木爆破法制浆的研究显示文摘实验室研究表明:杨木和桉木用亚钠预浸渍的爆破法制浆与化学药品加用量相同的常规CMP和CTMP相比,纸浆强度性质较好而磨浆单位能牦较低。 半工业规模试验表明:杨木爆破法浆比化学药品用量相同的CMP强度要好,单位能耗低。在大致相同的游离度下,得率85%的漂白杨木爆破法浆的强度性质相当于工业低得率(50%)的漂白硬木浆。 | 黄干强 B.V.Kokta A.Ahmed J.J.Garcean 陈小蓉 | 1991 | 中国造纸1991，10，6： | 12 |
| 2 | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury显示文摘Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure,a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury.Inflammasomes are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines,such as interleukin-1β and interleukin-18.These cytokines play a pivotal role in facilitating innate immune responses and inflammation.Among various inflammasome complexes,the NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is the best characterized,a crucial role for NLRP3 has been demonstrated in various brain diseases,including traumatic brain injury.Several recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain injury.Even more important,blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain injury.In this review,we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 inflammasome.Moreover,we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI,and current advances and challenges in potential NLRP3-targeted therapies.A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes. | Saifudeen Ismael Heba A.Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat | 2021 | Neural Regeneration Research2021，16，1： | 5 |
| 3 | The oncofetal protein IMP3 is an indicator of early recurrence and poor outcome in mucoepidermoid carcinoma of salivary glands显示文摘Objective: Mucoepidermoid carcinoma(MEC) is the most common primary malignancy of the salivary glands. Insulin-like growth factor-II m RNA-binding protein-3(IMP3) is an important prognostic factor in some cancers and a tool that differentiates between benign and malignant pancreatic lesions. This study aimed to identify a relationship between the expression of IMP3 and the outcome of salivary gland MEC, as well as to differentiate MEC from pleomorphic adenoma(PA).Methods: Tissue specimens from 70 cases of salivary gland MEC, 40 cases of PA, and 10 cases with normal salivary gland were examined immunohistochemically for IMP3. The association among the expression of IMP3, clinicopathological characteristics and patient's survival was assessed.Results: IMP3 was present in 51.4% of MEC but absent in PA and normal salivary gland tissues. IMP3 expression was associated with age > 60 years, submandibular gland tumors, tumor size > 4 cm, high-grade tumors, lymph node metastasis, involvement of surgical margins, perineural invasion, distant metastasis, advanced TNM stage, tumor relapse, and death(P<0.05). Increased expression of IMP3, tumors of the submandibular gland, and lymph node metastasis were independent prognostic factors of disease-free survival(DFS). In addition, IMP3 was a strong predictor of overall survival(OS) together with distant metastasis and intermediate and high-grade tumors.Conclusions: IMP3 expression is highly important in evaluating the outcome of MEC. IMP3 can be used to differentiate MEC from PA of salivary glands. | Mohamed R.Elshafey Rehab A.Ahmed Mohamed I Mourad Essam T.Gaballah | 2016 | Cancer Biology & Medicine2016，13，2： | 5 |
| 4 | Corrosion behavior of cold-rolled and post heat-treated 316L stainless steel in 0.9wt%NaCl solution显示文摘The effect of cold rolling and post-rolling heat treatment on the microstructural and electrochemical properties of the 316L stainless steel was investigated.Two-pass and four-pass cold-rolled stainless steel specimens were heat-treated by annealing at 900℃followed by quenching in water.During the cold rolling,the microstructure of the as-received specimen transformed from austenite to strain-inducedα′-martensite due to significant plastic deformation that also resulted in significant grain elongation(i.e.,~33%and 223%increases in the grain elongation after two and four rolling passes,respectively).The hardness of the heat-treated as-received specimen decreased from HV 190 to 146 due to the recovery and recrystallization of the austenite grain structure.The cyclic polarization scans of the as-rolled and heat-treated specimens were obtained in 0.9wt%NaCl solution.The pitting potential of the four-pass rolled specimen was significantly increased from 322.3 to 930.5 mV after post-rolling heat treatment.The beneficial effect of the heat treatment process was evident from~10-times-lower corrosion current density and two-orders-of-magnitude-lower passive current density of the heat-treated specimens compared with those of the as-rolled specimens.Similarly,appreciably lower corrosion rate(3.302×10^(−4)mm/a)and higher pitting resistance(1115.5 mV)were exhibited by the postrolled heat-treated specimens compared with the as-rolled 316L stainless steel specimens. | K.Bin Tayyab A.Farooq A.Ahmed Alvi A.Basit Nadeem K.M.Deen | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，3： | 4 |
| 5 | Bougainvillea spectabilis flowers extract protects against the rotenone-induced toxicity显示文摘Objective:To investigate the effect of two extracts of Bougainvillea spectabilis(B. spectabilis) flowers with yellow and pink/purple on brain oxidative stress and neuronal damage caused in rats by systemic rotenone injection. Methods:Rotenone 1.5 mg/kg was given three times per week alone or in combination with B. spectabilis flowers extracts(25 mg or 50 mg) via the subcutaneous route for 2 weeks. Brain concentrations of the lipid peroxidation marker malondialdehyde(MDA),reduced glutathione,nitric oxide(nitrite),the pro-inflammatory cytokine interleukin-1beta(Il-1β) as well as butyrylcholinesterase,and paraoxonase-1(PON-1) activities,were determined. Histopathology and caspase-3 immunohistochemistry were also performed. Results:Rotenone resulted in significant increases of brain MDA(the product of lipid peroxidation),and nitric oxide content along with decreased brain reduced glutathione. There were also marked and significant inhibition of brain PON-1 and BCh E activities and increased Il-1β in brain of rotenone-treated rats. B. spectabilis flowers extract itself resulted in brain oxidative stress increasing both lipid peroxidation and nitrite content whilst inhibiting PON-1 activity. The yellow flowers extract inhibited BCh E activity and increased brain Il-1β. When given to rotenone-treated rats,B. spectabilis extracts,however,decreased lipid peroxidation while their low administered doses increased brain GSH. Brain nitrite decreased by the pink extract but showed further increase by the yellow extract. Either extract,however,caused further inhibition of PON-1 activity while the yellow extract resulted in further inhibition of BChE activity. Histopathological studies indicated that both extracts protected against brain,liver and kidney damage caused by the toxicant. Conclusions:These data indicate that B. spectabilis flowers extracts exert protective effect against the toxic effects of rotenone on brain,liver and kidney. B. spectabilis flowers extracts decreased brain lipid peroxidation and prevented neuronal death due to rotenone and might thus prove the value in treatment of Parkinson's disease. | Omar M.E.Abdel-Salam Eman R.Youness Nadia A.Ahmed Sayed A.El-Toumy Ahmed M.A.Souleman Nermeen Shaffie Dalia M.Abouelfadl | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，5： | 2 |
| 6 | 常压塔顶换热器出口管道冲蚀特性的数值模拟显示文摘针对石化工业常压塔顶(常顶)系统中换热器出口管道的冲蚀失效问题,分别利用工艺仿真软件Aspen和计算流体力学软件,进行工艺计算和热器出口管道的三维流场数值模拟,得到多相流中腐蚀性介质的分布规律和流场结果。研究发现:管道内油气水三相流中均存在腐蚀性介质,其溶于水后形成的腐蚀性溶液对管道壁面产生腐蚀作用,生成的腐蚀产物保护膜在壁面剪切应力的作用下快速的脱落、再生,进而加速了管道的腐蚀破坏;流场中水相主要集中在管道的外侧,水相分率由外侧壁面至内侧壁面逐渐降低,在腐蚀性溶液聚集的外侧壁面,各弯管和直管段剪切应力沿流动方向逐渐增大;沿流动方向第四只弯管内侧由入口至30°之间区域、其它四只弯管外侧壁面沿流向30°至出口段和第三、四只弯管间直管外侧壁面,为水相分率和壁面剪切应力最大区域,即在腐蚀和流体剪切作用下失效的高风险区域,仿真结果与管道测厚结果基本吻合。 | 偶国富 AI-barakani A.Ahmed 许健 叶浩杰 金浩哲 | 2017 | 浙江理工大学学报(自然科学版)2017，37，4： | 1 |
| 7 | Central vein stenosis:a common problem in patients on hemodialysis显示文摘 | J.M.MacRae A.Ahmed N.Johnson A.Levin and M.Kiaii | | 0，，： | 1 |
| 8 | Proposed nomenclature for Pseudallescheria,Scedosporium and related genera显示文摘As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied taxa.The generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic conidia.Considering that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are proposed.Pseudallescheria minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and S.desertorum,respectively.Scedosporium prolificans is renamed as Lomentospora prolificans. | Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gené Fabiola Fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes | 2014 | Fungal Diversity2014，，4： | 1 |
| 9 | A Comparative Study on the Corrosion Performance of Ni_(47)Ti_(49)Co_4 and Ni_(51)Ti_(49) Shape Memory Alloys in Simulated Saliva Solution for Dental Applications显示文摘In this study, the corrosion behavior of Ni_(47)Ti_(49)Co_4 shape memory alloy(SMA) was investigated in simulated saliva solution with the binary alloy Ni_(51)Ti_(49) as a reference. The surface morphology and the chemical composition of the oxide films were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy before and after immersion in the test solutions, respectively. The results showed that the ternary alloy was less affected by the test solution,owning to the formation of passive layer composed mainly of the oxides of titanium and cobalt in several oxidation states.Cyclic voltammetry, electrochemical impedance spectroscopy and potentiodynamic polarization measurements affirmed that the passive oxide film significantly improved the corrosion resistance of Ni_(47)Ti_(49)Co_4 SMAs as demonstrated by the smaller corrosion current density, larger resistance and smaller capacitance. Consequently, alloying with cobalt, which has paramount importance in enhancing the passive layer, expands the use of Ni_(47)Ti_(49)Co_4 SMAs in dental work as new nitinol alloys with high corrosion resistances. | Rasha A.Ahmed | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，11： | 1 |
| 10 | Outcomes after escalation of infliximab therapy in ambulatory patients with moderately active ulcerative colitis显示文摘 | A.Ahmed A. CMoss | 2012 | Aliment Pharmacol Ther2012，，5： | 1 |
| 11 | 高负荷轴流压气机内以氦-氙混合气为工作介质的评估(英文)显示文摘本文评价了分子量为15g/mole 的氦-氙双项混合气体作为流动工质在核电厂轴流压气机的应用。由于纯氦具有普遍的传输特性,在很多情况下很难被压缩,因此是一种最佳的冷却剂。同时,纯氦工质在高温气冷堆(HTGR)的应用引起了涡轮机械的尺寸更大、质量越来越大、成本更高及叶轮机械的动力问题。为此,本文设计了一台高负荷氦氙压气机,并对其性能进行了分析。结果显示,只有18%的氦气压气机级需要在高负荷氦气-氙气压气机中将气体压缩至所需压力。通过设计分析,工作在闭式布雷顿循环(CBC)中高温气冷堆(HTGR)压气机,可由16 级减少到2 级。因此,在高温气冷堆电厂的涡轮压压气中,氦氙比纯氦更有优势。 | Adil Malik Qun Zheng Hamza Fawzy Naseem Ahmed Salman A.Ahmed | 2019 | 风机技术2019，61，2： | 1 |
| 12 | Rotational flow of Oldroyd-B nanofluid subject to Cattaneo-Christov double diffusion theory显示文摘A nanofluid is composed of a base fluid component and nanoparticles, in which the nanoparticles are dispersed in the base fluid. The addition of nanoparticles into a base fluid can remarkably improve the thermal conductivity of the nanofluid, and such an increment of thermal conductivity can play an important role in improving the heat transfer rate of the base fluid. Further, the dynamics of non-Newtonian fluids along with nanoparticles is quite interesting with numerous industrial applications. The present predominately predictive modeling studies the flow of the viscoelastic Oldroyd-B fluid over a rotating disk in the presence of nanoparticles. A progressive amendment in the heat and concentration equations is made by exploiting the Cattaneo-Christov heat and mass flux expressions. The characteristic of the Lorentz force due to the magnetic field applied normal to the disk is studied. The Buongiorno model together with the Cattaneo-Christov theory is implemented in the Oldroyd-B nanofluid flow to investigate the heat and mass transport mechanism. This theory predicts the characteristics of the fluid thermal and solutal relaxation time on the boundary layer flow. The von K′arm′an similarity functions are utilized to convert the partial differential equations(PDEs) into ordinary differential equations(ODEs). A homotopic approach for obtaining the analytical solutions to the governing nonlinear problem is carried out. The graphical results are obtained for the velocity field, temperature, and concentration distributions. Comparisons are made for a limiting case between the numerical and analytical solutions, and the results are found in good agreement. The results reveal that the thermal and solutal relaxation time parameters diminish the temperature and concentration distributions, respectively. The axial flow decreases in the downward direction for higher values of the retardation time parameter. The impact of the thermophoresis parameter boosts the temperature distribution. | A.HAFEEZ M.KHAN A.AHMED J.AHMED | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，7： | 1 |
| 13 | Review of the Integrated Groundwater and Surface‐Water Model (IGSM)显示文摘 | Eric M.LaBolle Ayman A.Ahmed Graham E.Fogg | 2005 | Ground Water2005，，2： | 1 |
| 14 | Geochemistry of lamprophyre dykes, Wadi Sikait area, South Eastern Desert, Egypt显示文摘The Wadi Sikait area lies at about 95 km southwest of Marsa Alam City along the Red Sea Coast, Eastern Desert, Egypt. It is occupied by Precambrian rocks of ophiolitic mélange, metamorphosed sandstones (MSS), gab-bros and monzogranites which were later intruded by lamprophyre dykes and quartz veins. The lamprophyre dykes were extruded in NW-SE and NE-SW trends cutting monzogranites and metamor-phosed sandstones. The lamprophyres are porphyritic and composed of clinopyroxene, olivine and amphibole phenocrysts enclosed in a fine-grained groundmass of clinopyroxene, amphibole, opaque and lithium mica. The al-teration products are represented by amphibole (tremolite-actinolite and hornblende), carbonate, epidote, chlorite, iddingsite, clay minerals, limonite and serpentine. The Sikait lamprophyre dykes can be classified as alkaline lamprophyres characterized by silica contents rang-ing from 41.65 wt% to 50.88 wt% and Na2O>K2O. They are enriched in LILE, LREE and HFSE, but strongly de-pleted in compatible elements such as Cr and Ni relative to the primitive mantle. Sikait lamprophyres have moderate Zr/Hf (35.6-52.8) and Nb/Ta (20.5-22.5) ratios. Most of these features are attributed to the origin of these dykes from the metasomatized mantle affected by subduction-related fluid. These lamprophyres are compositionally similar to Salu lamprophyres in eastern China. The Sikait lamprophyre samples have high LREE (320×10-6-419×10-6) relative to HREE (20×10-6-33×10-6) with ratios (LREE/HREE=11.6-18.7) and no negative Eu anomaly (Eu/Eu*=0.9-1.04). The relative presence of posi-tive Ce anomaly (Ce/Ce*=1.04) in lamprophyre samples suggests the oxidizing condition under which the REEs were precipitated due to the common occurrence of fluorite and apatite. | Ibrahim M.El-Ahmadi Ragab A.Ahmed | 2011 | Chinese Journal Of Geochemistry2011，30，3： | 0 |
| 15 | Leaf gas exchange characteristics,biomass partitioning,and water use efficiencies of two C4 African grasses under simulated drought显示文摘Background:Few studies have evaluated the effect of drought on the morphophysiological characteristics of African C_(4) grasses.We investigated how drought affects leaf gas exchange characteristics,biomass partitioning,and water use efficiencies of Enteropogon macrostachyus and Cenchrus ciliaris.Methods:The grasses were grown in a controlled environment under optimum conditions,that is,70%of the maximum water‐holding capacity(WHC)for the first 40 days.Thereafter,half of the columns were maintained under optimum or drought conditions(30%of maximum WHC)for another 20 days.Results:Under optimum conditions,C.ciliaris showed a significantly higher photosynthetic rate,stomatal conductance,and transpiration rate than E.macrostachyus.Drought decreased the photosynthetic rate,stomatal conductance and transpiration rate only in C.ciliaris.The net photosynthetic rate,stomatal conductance,and leaf transpiration of E.macrostachyus did not differ significantly under optimum and drought conditions.E.macrostachyus showed an increase in its water use efficiencies under drought to a greater extent than C.ciliaris.Conclusions:Our results demonstrate that C.ciliaris is more sensitive to drought than E.macrostachyus.The decrease in the intercellular CO_(2) concentration and the increase in stomatal limitation with drought in C.ciliaris and E.macrostachyus suggest that stomatal limitation plays the dominant role in photosynthesis of the studied African C_(4) grasses. | Kevin Z.Mganga Jana Kuhla Andrea Carminati Johanna Pausch Mutez A.Ahmed | 2023 | Grassland Research2023，2，1： | 0 |
| 16 | Thermal analysis in swirl motion of Maxwell nanofluid over a rotating circular cylinder显示文摘In this paper,the mechanism of thermal energy transport in swirling flow of the Maxwell nanofluid induced by a stretchable rotating cylinder is studied.The rotation of the cylinder is kept constant in order to avoid the induced axially secondary flow.Further,the novel features of heat generation/absorption,thermal radiation,and Joule heating are studied to control the rate of heat transfer.The effects of Brownian and thermophoretic forces exerted by the Maxwell nanofluid to the transport of thermal energy are investigated by utilizing an effective model for the nanofluid proposed by Buongiorno.The whole physical problem of fluid flow and thermal energy transport is modelled in the form of partial differential equations(PDEs)and transformed into nonlinear ordinary differential equations(ODEs)with the help of the suitable flow ansatz.Numerically acquired results through the technique bvp4c are reported graphically with physical explanation.Graphical analysis reveals that there is higher transport of heat energy in the Maxwell nanoliquid for a constant wall temperature(CWT)as compared with the prescribed surface temperature(PST).Both thermophoretic and Brownian forces enhance the thermal energy transport in the flowing Maxwell nanofluid.Moreover,the temperature distribution increases with increasing values of the radiation parameter and the Eckert number.It is also noted that an increase in Reynolds number reduces the penetration depth,and as a result the flow and transport of energy occur only near the surface of the cylinder. | A.AHMED M.KHAN J.AHMED | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，9： | 0 |
| 17 | Repurposing verapamil for prevention of cognitive decline in sporadic Alzheimer's disease显示文摘Dementia is currently the only leading cause of death that is still on the rise,with its overall costs already surpassing those of cancer and heart disease combined,it has developed into a worldwide crisis.In response to its serious and far-reaching effects,the US government has established the'National Alzheimer's Project Act'(Public Law 111-375). | Heba A.Ahmed Tauheed Ishrat | 2022 | Neural Regeneration Research2022，17，5： | 0 |
| 18 | Disturbance Evaluation in Power System Based on Machine Learning显示文摘The operation complexity of the distribution system increases as a large number of distributed generators(DG)and electric vehicles were introduced,resulting in higher demands for fast online reactive power optimization.In a power system,the characteristic selection criteria for power quality disturbance classification are not universal.The classification effect and efficiency needs to be improved,as does the generalization potential.In order to categorize the quality in the power signal disturbance,this paper proposes a multi-layer severe learning computer auto-encoder to optimize the input weights and extract the characteristics of electric power quality disturbances.Then,a multi-label classification algorithm based on rating is proposed to understand the relationship between the labels and identify the various power quality disturbances.The two algorithms are combined to construct a multi-label classification model based on a multi-level extreme learning machine,and the optimal network structure of the multi-level extreme learning machine as well as the optimal multi-label classification threshold are developed.The proposed method can be used to classify the single and compound power quality disturbances with improved classification effect,reliability,robustness,and anti-noise performance,according to the experimental results.The hamming loss obtained by the proposed algorithm is about 0.17 whereas ML-RBF,SVM and ML-KNN schemes have 0.28,0.23 and 0.22 respectively at a noise intensity of 20 dB.The average precision obtained by the proposed algorithm 0.85 whereas the ML-RBF,SVM and ML-KNN schemes indicates 0.7,0.77 and 0.78 respectively. | Emad M.Ahmed Mohamed A.Ahmed Ziad M.Ali Imran Khan | 2022 | Computers, Materials & Continua2022，，4： | 0 |
| 19 | Hydrocarbon generating-potential and maturity-related changes of the Khatatba Formation, Western Desert, Egypt显示文摘The petroliferous province of the Western Desert comprises several sedimentary basins with different hydrocarbon potentiality and production capability.The middle Jurassic Khatatba Formation was proved a potential source rock in some basins and active/effective in others.The current study aims to give a comprehensive assessment and evaluation of the potential organic-rich intervals of the Khatatba Formation across JG and JD fields,northeast Abu Gharadig Basin(NEAG).The hydrocarbon generating capability and sourcing of the Khatatba Formation studied through organic geochemistry calibrated with well logging.However,the efficiency of some widely used plots of geochemistry is re-evaluated according to their accuracy and consistency.Forty cuttings,thirteen cores and two oil samples obtained from three wells(JG-2,JG-3 and JD-4)were evaluated.The samples revealed total organic carbon(TOC)values ranging from 1 to 9 wt%,exhibiting a good-excellent potential source rock.A single sample in the JD-4 well attained a TOC value of 21.3 wt%with a generating potential(represented by S2 parameter)exceeding 146 mgHc/g rock required a special evaluation.Most of the samples(mainly in the JD-4 well)attained a sufficient level of thermal maturity for hydrocarbon generation with a Tmax up to 449C.The vitrinite reflectance(%Ro)values(a common maturity-related indicator)acquired from the JD-4 well ranging between 0.76%and 0.92%.These values are tediously increasing with depth indicating a uniform geothermal regime.The Khatatba organofacies,with wide variety of kerogen types(I,II,II-S and II/III),contain marine organic matter with a slight terrigenous input,exhibiting anoxic-suboxic environmental conditions.Oil-source correlations define the organic-rich intervals responsible for charging the accumulated hydrocarbon in the NEAG concession. | Mohammed A.Ahmed Mostafa M.A.Hassan | 2019 | Petroleum Research2019，4，2： | 0 |
| 20 | Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis显示文摘Ivermectin is a US Food and Drug Administration(FDA)-approved antiparasitic agent with antiviral and anti-inflammatory properties.Although recent studies reported the possible anti-inflammatory activity of ivermectin in respiratory injuries,its potential therapeutic effect on pulmonary fibrosis(PF)has not been investigated.This study aimed to explore the ability of ivermectin(0.6 mg/kg)to alleviate bleomycin-induced biochemical derangements and histological changes in an experimental PF rat model.This can provide the means to validate the clinical utility of ivermectin as a treatment option for idiopathic PF.The results showed that ivermectin mitigated the bleomycin-evoked pulmonary injury,as manifested by the reduced infiltration of inflammatory cells,as well as decreased the inflammation and fibrosis scores.Intriguingly,ivermectin decreased collagen fiber deposition and suppressed transforming growth factor-β1(TGF-β1)and fibronectin protein expression,highlighting its anti-fibrotic activity.This study revealed for the first time that ivermectin can suppress the nucleotide-binding oligomerization domain(NOD)-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome,as manifested by the reduced gene expression of NLRP3 and the apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),with a subsequent decline in the interleukin-1β(IL-1β)level.In addition,ivermectin inhibited the expression of intracellular nuclear factor-κB(NF-κB)and hypoxia‑inducible factor‑1α(HIF-1α)proteins along with lowering the oxidative stress and apoptotic markers.Altogether,this study revealed that ivermectin could ameliorate pulmonary inflammation and fibrosis induced by bleomycin.These beneficial effects were mediated,at least partly,via the downregulation of TGF-β1 and fibronectin,as well as the suppression of NLRP3 inflammasome through modulating the expression of HIF‑1αand NF-κB. | Mai A.ABD-ELMAWLA Heba R.GHAIAD Enas S.GAD Kawkab A.AHMED Maha ABDELMONEM | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，8： | 0 |
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