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| 1 | Serum microRNA‐122 levels in different groups of patients with chronic hepatitis B virus infection显示文摘 | O.Waidmann V.Bihrer T.Pleli H.Farnik A.Berger S.Zeuzem B.Kronenberger A.Piiper | 2012 | Journal of Viral Hepatitis2012，，2： | 3 |
| 2 | Complex multimorbidity and health outcomes in older adult cancer survivors显示文摘Objective:To characterize complex multimorbidity among cancer survivors and evaluate the association between cancer survivorship,time since cancer diagnosis,and self-reported fair/poor health,self-rated worse health in 2 years,and 2-year mortality.Methods:We used the 2010-2012 Health and Retirement Study.Cancer survivors were indi-viduals who reported a(nonskin)cancer diagnosis 2 years or more before the interview.We defined complex multimorbidity as the co-occurrence of chronic conditions,functional limitations,and/or geriatric syndromes.In addition to descriptive analyses,we used logistic regression to evaluate the independent association between cancer survivor status and health outcomes.We also examined whether cancer survivorship differed by the number of years since diagnosis.Results:Among 15,808 older adults(age≥50 years),11.8%were cancer survivors.Compared with cancer-free individuals,a greater percentage of cancer survivors had complex multimorbidity:co-occurring chronic conditions,functional limitations,and geriatric syndromes.Cancer survivor-ship was significantly associated with self-reported fair/poor health,self-rated worse health in 2 years,and 2-year mortality.These effects declined with the number of years since diagnosis for fair/poor health and mortality but not for self-rated worse health.Conclusion:Cancer survivor status is independently associated with more complex multi-morbidity,and with worse health outcomes.These effects attenuate with time,except for patient perception of being in worse health. | David F.Warner Nicholas K.Schiltz Kurt C.Stange Charles W.Given Cynthia Owusu Nathan A.Berger Siran M.Koroukian | 2017 | Family Medicine and Community Health2017，5，2： | 1 |
| 3 | Consistency Conditions for Regulatory Analysis of Financial Institutions:A Comparison of Frontier Efficiency Method显示文摘 | Bauer P A.Berger N.Ferrier D.Humphrey | | 0，，： | 1 |
| 4 | Insulin resistance, central obesity, and risk of colorectal adenomas显示文摘 | Ana PatriciaOrtiz Cheryl L.Thompson AmitabhChak Nathan A.Berger LiLi | 2012 | Cancer2012，，7： | 1 |
| 5 | 地质时期古气候研究中的天文周期的稳定性显示文摘在过去500Ma的地质时期内影响地球气候的基本天文频率的预期变化也许能在地质记录中识别出来,并且这种影响已在几种情况下推理得出.计算结果表明,由于过去5亿年内,地-月距离以及日长随地质年龄增大而缩短,导致基本周期如黄赤交角周期及气候差周期由54至35,41至29,23至19和19至16千年的缩短,而在这一时间内,岁差常数由50弧秒/年增至61弧秒/年.由于行星系统不规则运动所造成的基频的改变极小,它们对气候岁差周期、黄赤交角周期及地球绕日轨道的偏心率周期的影响可以忽略不计,医此,用于研究第四纪气候的偏心事周期对前第四纪而言也许可以认为是大致恒定的. | A.Berger 吴智勇 | 1993 | 地球物理学进展1993，8，3： | 1 |
| 6 | Short sleep duration as a contributor to racial disparities in breast cancer tumor grade显示文摘Although African Americans(AAs)are less likely to get breast cancer than European Americans(EAs),they get more aggressive forms.We previously showed that short sleep is associated with higher tumor grade.It is well documented that AAs get less sleep,on average,than EAs.We studied the contribution of short sleep to racial disparities in breast cancer aggressiveness among 809 invasive breast cancer patients who responded to a survey on their lifestyle.Multivariable regressions and mediation analyses were performed to assess the effect of sleep duration on the association of race with tumor grade.AAs reported shorter average sleep(mean[standard devia-tion]6.57[1.47]h)than EAs(mean[standard deviation]7.11[1.16]h;P<0.0001)and were almost twice as likely to report less than 6 h of sleep per night(48.0%vs.25.3%,P<0.0001).AA patients were more likely to have high-grade tumors(52.6%vs.28.7%in EAs,P=0.0002).In multivariate analysis,race was associated with tumor grade(P<0.0001).On adjustment for sleep duration,the effect of race was reduced by 7.1%,but remained statistically significant(P=0.0006).However,the Sobel test did not indicate statistical significance(z=1.69,P=0.091).In other models accounting for these and additional confounders,we found similar results.Because of the conservative nature of the mediation analysis and smaller sample size,replication of our results in larger studies with more AA patients is warranted. | Kevin Allan Nathan A.Berger Li Li Cheryl L.Thompson | 2017 | Family Medicine and Community Health2017，5，2： | 0 |
| 7 | Thrombotic Thrombocytopenic Purpura in a Parturient Leading to Life-Threatening Thrombocytopenia and Neonatal Demise—A Case Report显示文摘Thrombocytopenia is common (up to 12%) in pregnancy;thrombotic thrombocytopenia is a rare cause of thrombocytopenia;however,it is immediately life-threatening to both mother and fetus and requires immediate intervention.This is compounded by the need to act on a presumptive diagnosis with high level of suspicion given the relatively long laboratory confirmation time.A 31-year-old gravida 3,para 1 parturient at 26 weeks of gestation presented to outside hospital with recent onset of easy bruising and blurry vision.A blood count was drawn and showed a platelet count of 19,000/μL.She was transferred to our institution for management where an initial diagnosis of preeclampsia with severe features was made based on thrombocytopenia and fetal growth restriction (<1%).Platelet count nadired at 14,000/μL and a blood smear showed schistocytes,suggesting microangiopathic hemolysis,prompting discussion of urgent cesarean delivery and anesthesia consult.An urgent hematology consult led to presumptively diagnosing thrombotic thrombocytopenic purpura and cesarean delivery was deferred after discussion with the patient and team.Plasma exchange and steroid therapy were started promptly,and her platelet count improved within 12 hours.Unfortunately,the patient experienced neonatal demise.Undetectable ADAMTS13 levels confirmed diagnosis of thrombotic thrombocytopenia.She was transitioned to rituximab,platelets recovered to baseline,and she continues to do well.Thrombotic thrombocytopenia is a rare,life-threatening cause of thrombocytopenia in pregnancy.Despite grim fetal prognosis,especially in early pregnancy,low threshold of suspicion,early anesthesia involvement,and multi-disciplinary approach can facilitate diagnosis and timely intervention.In our case,it was likely lifesaving. | Amnon A.Berger John J.Kowalczyk Philip E.Hess Yunping Li | 2023 | Maternal-Fetal Medicine2023，5，2： | 0 |
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