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| 1 | 美国优质紫花苜蓿在宁夏中部干旱带的适应性研究显示文摘以宁夏盐池县本地苜蓿XM及宁夏益科农业科技有限公司引进的15个美国紫花苜蓿品种为研究对象,综合考虑生育期、株高、密度、产草量、茎叶比、越冬率等指标,开展苜蓿引种适应性研究.结果表明,以本地种XM为对照,15个外引种紫花苜蓿在生长发育特性上存在显著差异.其中,以品种ZHM,E3006,D4,D2表现较优,其返青早,青绿期长,鲜草产量分别是对照的1.52,1.45,1.28,1.25倍,干草产量分别是对照的1.46,1.25,1.22,1.19倍,且抗旱性强,品质优良,适宜在宁夏盐池县等中部干旱带大面积推广应用. | 高婷 张晓刚 纪立东 Orson Boyce Stanford A.Young 朱建宁 彭文栋 | 2009 | 宁夏大学学报(自然科学版)2009，30，3： | 6 |
| 2 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 3 | 职业生涯背景行动理论及其方法的述评显示文摘背景行动理论是职业生涯研究中的新理论。此理论以人类职业行动为基本研究单位,认为:(1)人类的职业行动在本质上都是意向性和目标指向的;(2)应在日常生活中了解人们的职业观念、解释和选择;(3)职业是社会建构的。行动-项目质性方法基于此理论产生,从外显行为、内在过程和社会意义三方面收集职业行动的完整信息。背景行动理论对职业行动、发展过程及社会意义的认识为职业生涯研究提供了新的理论视角。 | 曲可佳 Richard A.Young 邹泓 余益兵 | 2010 | 心理科学进展2010，18，10： | 3 |
| 4 | Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression显示文摘The interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity.We have generated a unique murine model named ARE-Del,with chronic overexpression of IFNγ,by altering IFNγmetabolism.Importantly,these mice develop an immunologic and clinical profile similar to patients with primary biliary cholangitis,including high titers of autoantibodies and portal inflammation.We hypothesized that the downregulation of IFN signaling pathways with a JAK1/2 inhibitor would inhibit the development and progression of cholangitis.To study this hypothesis,ARE-Del^(+/−)mice were treated with the JAK1/2 inhibitor ruxolitinib and serially studied.JAK inhibition resulted in a significant reduction in portal inflammation and bile duct damage,associated with a significant reduction in splenic and hepatic CD4^(+)T cells and CD8^(+)T cells.Functionally,ruxolitinib inhibited the secretion of the proinflammatory cytokines IFNγand TNF from splenic CD4^(+)T cells.Additionally,ruxolitinib treatment also decreased the frequencies of germinal center B(GC B)cells and T follicular helper(Tfh)cells and led to lower serological AMA levels.Of note,liver and peritoneal macrophages were sharply decreased and polarized from M1 to M2 with a higher level of IRF4 expression after ruxolitinib treatment.Mechanistically,ruxolitinib inhibited the secretion of IL-6,TNF and MCP1 and the expression of STAT1 but promoted the expression of STAT6 in macrophages in vitro,indicating that M1 macrophage polarization to M2 occurred through activation of the STAT6-IRF4 pathway.Our data highlight the significance,both immunologically and clinically,of the JAK/STAT signaling pathway in autoimmune cholangitis. | Tihong Shao Patrick S.C.Leung Weici Zhang Koichi Tsuneyama William M.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari M.Eric Gershwi | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 5 | 近地表未固结淤积层中的SH波勘探显示文摘过去的10年,广泛的技术创新带来了油气储量勘探和开发方法的巨大进步.其中的一个主要例子就是在海上石油与天然气勘探中采用横波对气云下方的反射层进行了成像.这项技术在20世纪90年代完成了从发展初期到走向成熟的过程,现在已整合到各种商业处理软件包中,并在许多情况下得到了成功应用.最近一次SEG年会和本期专集(即2001年9月出版的--译者注)记录了许多转换波(P-SV)的应用实例.然而,能源工业界对SH波(另一种类型的横波)的研究却很少.与此相反,SH波的近地表应用却受到了越来越多的关注.本文简要地回顾了过去10年中能源工业在横波技术方面取得的进步,这些进步为目前SH波在近地表的应用开辟了途径.本文以未固结淤积环境为例,说明对P波和SH波资料进行综合解释的优越性. | Roger A.Young 刘原英 张保庆 | 2002 | 勘探地球物理进展2002，25，4： | 1 |
| 6 | Analysis of DFT-based frequency excision algorithms for direct-sequence spread-spec-trum communications显示文摘 | Jeffrey A.Young James S.Lehnert | | 0，，08： | 1 |
| 7 | Modeling net ecosystem metabolism with an artificial neural network and Bayesian belief network显示文摘 | William A.Young Ⅱ David F.Millie | | 0，，26： | 1 |
| 8 | Stock Price reaction of multinational firms to Exchange realignments显示文摘 | Frank P A.Young | | 0，，： | 1 |
| 9 | The expression and function of microRNAs in chondrogenesis and osteoarthritis显示文摘 | Tracey E.Swingler GuyWheeler VirginiaCarmont Hannah R.Elliott Matthew J.Barter MuhammadAbu‐Elmagd Simon T.Donell Raymond P.Boot‐Handford Mohammad K.Hajihosseini AndreaMünsterberg TamasDalmay David A.Young Ian M.Clark | 2012 | Arthritis & Rheumatism2012，，6： | 1 |
| 10 | Revealing stratigraphy in ground-penetrating radar data using domain filtering显示文摘 | Roger A.young Jingsheng Sun | | 0，，02： | 1 |
| 11 | 查看详情显示文摘 | N.Mannella A.Rosenhahn M.Watanabe B.Sell A.Nambu S.Ritchey E.Arenholz A.Young Y.Tomioka and C.S.Fadley | | 0，，： | 1 |
| 12 | Marketing Continuing CareRetirement Communities显示文摘 | Cheri A.Young Kathleen Pearl Brewer | | 0，，： | 1 |
| 13 | The Web as an E-Commerce Medium:An Ex-ploratory Study of Consumer Perceptions in a Restaurant Set-ting显示文摘 | Joyce A.Young Paul W.Clark Faye S.McIntyre | | 0，，1： | 1 |
| 14 | 宁夏中部风沙区草场表层土壤储水分布特征研究显示文摘为了从涵养水分角度验证牧草引种适应性效果,试验采用实时定位、动态监测方法对宁夏中部风沙区天然草场、美国优质牧草引种试验区0-40 cm层次土壤储水量分布特征进行对比探讨。结果表明:宁夏中部风沙区天然草场土壤水分与大气降水关系密切,土壤储水量以5—7月份为显著失墒期,8—9月份为明显增墒期,10—11月份为缓慢退墒期,11月份—翌年4月份为保墒期。美国优质牧草引种改良区年内及翌年土壤储水量均低于未改良区,而引种3年的牧草地土壤储水量显著高于未改良区,说明宁夏中部风沙区优质牧草需要持续一定年限的引种示范,才能使外引种真正演变为本地适应性优良的土生种,年限至少在3年以上。 | 高婷 张晓刚 纪立东 Orson Boyce Stanford A.Young 朱建宁 彭文栋 | 2011 | 黑龙江畜牧兽医2011，，4： | 1 |
| 15 | 美国新泽西州Reading Prong一种新的铁辉石和铁-易变辉石的产状显示文摘人们在新泽西州靠近伯克郡峡谷Reading Prong的含铁橄榄石-钙铁辉石-石英-正长岩中发现了以分散粒状和片状与钙铁辉石交生的铁辉石和富铁-易变辉石。辉石温度计测温表明,这些极富铁的辉石很可能在910℃以上开始结晶,出溶辉石叶片的组成表明其封闭温度大约在550~600℃之间,结晶过程中的压力约(6~6.5)×10~8Pa,氧逸度的变化范围为(10^(-12)~10^(-17))×10~6Pa,不低于QFM下的1个log单位。这些数据表明,含石英-正长岩的Reading Prong西北部在10亿年前位于地下约22km深处。 | Davis A.Young John Cuthbertson 刁凤琴 | 1994 | 地质科学译丛1994，11，4： | 0 |
| 16 | A Novel Atlas-Based Strategy for Understanding Cardiac Dysfunction in Patients with Congenital Heart Disease显示文摘Tetralogy of Fallot(TOF)is the most common form of cyanotic congenital heart disease.Infants diagnosed with TOF require surgical interventions to survive into adulthood.However,as a result of postoperative structural malformations and long-term ventricular remodeling,further interventions are often required later in life.To help identify those at risk of disease progression,serial cardiac magnetic resonance(CMR)imaging is used to monitor these patients.However,most of the detailed information on cardiac shape and biomechanics contained in these large four-dimensional(4D)data sets goes unused in clinical practice for lack of efficient and comprehensive quantitative analysis tools.While current global metrics of cardiac size and function,such as indexed ventricular mass and volumes,can identify patients at risk of further complications,they are not adequate to explain the underlying mechanisms causing the postoperative malfunctions,and help cardiologists plan optimal personalized treatments.We are proposing a novel approach that uses 4D ventricular shape models derived from CMR imaging exams to generate statistical atlases of ventricular shape and finite-element models of ventricular biomechanics to identify specific features of cardiac shape and biomechanical properties that explain variations in ventricular function.This study has the potential to discover novel biomarkers that precede adverse ventricular remodeling and dysfunction. | Sara Salehyar Nickolas Forsch Kathleen Gilbert Alistair A.Young James C.Perry Sanjeet Hegde Jeffrey H.Omens Andrew D.McCulloch | 2019 | Molecular & Cellular Biomechanics2019，16，3： | 0 |
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