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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Short - channel effects and drain - induced barrier lowering in nanometerscale GaAs MESFET's 显示文摘 | James A Adams Thayne I G Wilkinson C D W | 1993 | IEEE Trans Electron Devices1993，40，6： | 1 |
| 3 | Inhibition of avian leukosis virus replication by vector-based RNA interference显示文摘 | Chen M Adam J G Matthew W | 2007 | Virology2007，365，： | 1 |
| 4 | Effects of wildfire on soils and watershed processes 显示文摘 | lee G G Neary D G Adams P W | 2004 | Journal of Forestry2004，102，6： | 1 |
| 5 | Pseudobulb injected growth regulators as aids for year around production of Hawaiian Dendrobium orchid cut flowers 显示文摘 | SAKAI W S ADAMS C BRAUN G | 2000 | Acta Horticuhurae2000，514，2： | 1 |
| 6 | Osteoblastic cells regulate the haematopoietic stem cell niche 显示文摘 | CALVI L M ADAMS G B WEIBRECHT K W | 2003 | Nature2003，425，6960： | 1 |
| 7 | Alkylphenol ethoxylates in the environment显示文摘 | Naylor C G Mieure J P Adams W J Weeks J A Castaldl F J Ogle L D Romano R R | 1992 | American Oil Chemists Society1992，69，： | 1 |
| 8 | Osteoblastic cells regulate the haematopoietic stem cell niche显示文摘 | Calvi L M Adams G B Weibrecht K W | 2003 | Nature2003，425，6960： | 1 |
| 9 | Anemia as a risk factor and therapeutic target in heart failure显示文摘 | Felker G M Adams K F Gattis W A | 2004 | J Am Coll Cardiol2004，44，： | 1 |
| 10 | Alkylphenol ethoxylates in the environment显示文摘 | NAYLOR C G MIEURE J P ADAMS W J | 1992 | Am Oil Chem Soc1992，69，7： | 1 |
| 11 | Lsoflurane and cerebmspinal fluid pressure in neurosurgical patients显示文摘 | ADAMS R W CUCCHIARA R F GRONER G A | 1981 | Anesthesiology1981，54，2： | 1 |
| 12 | Relationships of job and family involvement, family social support, and work- family conflict with job and life satisfaction显示文摘 | Adams G A King L A King D W | 1996 | Journal of Applied Psychology1996，81，4： | 1 |
| 13 | Quantitative echotexture analysis of bovine corpora lutea显示文摘 | Tom J W Pierson R A Adams G P | 1998 | Theriogenology1998，49，7： | 1 |
| 14 | Alkylphenol Ethoxylates in the Environment 显示文摘 | NAYLOR C G MIEURE J P ADAMS W J et (d | 1992 | Journal of the American Oil Chemists Society1992，69，7： | 1 |
| 15 | CART: fromgeneto function显示文摘 | Adams L D Gong W Vechia S D Hunter R G Kuhar M J | 1999 | BrainRes1999，848，12： | 1 |
| 16 | Alkylphenol ethoxylates in the envireonment显示文摘 | Naylor C G J P Mieure W J Adams F J Castaldi L D Ogle R R Romano | 1992 | The American Oil Chemists'' Society1992，69，： | 1 |
| 17 | Electrochemical efficiency in multiple discharge/recharge cycling of supercapacitors in hybrid EV applications显示文摘 | Pell W G Conway B E Adams W A | 1999 | J Power Sources1999，80，12： | 1 |
| 18 | Semantic indexing of multimedia content using visual, audio and text cues 显示文摘 | Adams W H Iyengar G Lin C Y | 2003 | Eurasip Journal on Applied Signal Processing2003，2003，2： | 1 |
| 19 | The genome sequence of Drosophila melanogaster显示文摘 | Adams M D Celniker S E Holt R A Evans C A Gocayne J D Amanatides P G Scherer S E Li P W Hoskins R A Galle R F | | 0，，： | 1 |
| 20 | Barriers to and Drivers for UK Bioenergy Development显示文摘 | Adams P W Hammond G P Mcmanus M C | 2011 | Renewable and Sustainable Energy Re- views2011，15，2： | 1 |
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