| 2 | Extraction of protein from churpi of yak milk origin:Size reduction,nutraceutical potential and as a wall material for resveratrol显示文摘Resveratrol is a known anti-oxidant and anti-cancer bioactive.The low bioavailability and poor water solubility of resveratrol is a major barrier that restricts its usage in food applications.To overcome these problems,the study presents micro and nano encapsulation of resveratrol in casein micelles extracted from Himalayan cheese(Churpi).Resveratrol loaded casein microparticles(CS-rm)were obtained using emulsion-freeze drying.Whereas,resveratrol loaded casein nanoparticles(CS-rn)were obtained using ultrasonication.Both were characterized using dynamic light scattering(DLS),scanning electron microscopy(SEM)and attenuated total reflectance-fourier transform infrared spectroscopy(ATR-FTIR).DLS revealed hydrodynamic diameter of 71.24μm and 387.023 nm and zeta potential of-22.62 and-28.08 mV for CS-rm and CS-rn.FTIR confirmed the characteristic peaks of resveratrol at 965.4,1380.86,1586.66 and 1607 cm-1 confirmed successful micro and nanoencapsulation.CS-rm displayed high encapsulation efficiency(52.32%)and swelling power(77.90 at pH 3 and 68.65 at pH 7.5)than CS-rn.Both micro and nanoencapsulation protected resveratrol in gastric conditions,however,CS-rn showed high release of resveratrol then CS-rm in simulated intestinal conditions.The anti-oxidant and anti-cancer activity of resveratrol under simulated gastric and intestinal conditions(SGID)was significantly higher(p≤0.05)for CS-rn,showing that nanoencapsulation improved release and nutraceutical profile of resveratrol.Resveratrol loaded nano and micro casein particles can be used a source of fortified protein supplement in growing food and nutraceutical industry. | Asir Gani Nairah Noor Adil Gani Jenno Joseph-Leenose-Helen Asima Shah Zanoor ul Ashraf | 2022 | Food Bioscience2022，46，2： | 0 |
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