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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 茶叶摄入与中国成年人高密度脂蛋白胆固醇浓度纵向变化的关系显示文摘茶叶摄入与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)浓度的年龄相关变化之间的关系仍不清楚。该研究目的是探索茶摄入量与HDL-C浓度纵向变化之间的关系。研究人员通过调查问卷评估基线(2006年)的茶叶消费量,并在2006、2008、2010和2012年测量了未患有心血管病或癌症. | 刘莉 叶鹏 Huang S Li J Wu Y Ranjbar S Xing A Zhao H Wang Y Shearer GC Bao L Lichtenstein AH Wu S Gao X | 2018 | 中华高血压杂志2018，26，8： | 5 |
| 3 | Mitogenicity of the recombinant myco- bacterial 27-kilodalton lipoprotein is not connected to its anti- protective effect 显示文摘 | Hovav AH Davidoviteh L Nussbaum G Mullerad J Fish- man Y Bercovier H | 2004 | Infect Immun2004，72，6： | 1 |
| 4 | Isolation and primary structure of NGAL,a novel protein associated with human neutro- phil gelatinase 显示文摘 | Kjeldson L Johnsen AH Sengelov H | 1993 | J Biol Chem1993，268，10： | 1 |
| 5 | Isolation and pri- mary structure of NGAL,a novel protein associated with hu-man neutrophil gelatinase显示文摘 | Kjeldsen L Johsen AH Sengelov H | 1993 | J Biol Chem1993，268，10： | 1 |
| 6 | Isolation and primary structure of NGAL,a novel protein associated with human neutrophil gelatinase 显示文摘 | Kjeldsen L Johnsen AH Sengelov H | 1993 | J Biol Chem1993，268，10： | 1 |
| 7 | Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase显示文摘 | KJELDSEN L JOHNSEN AH SENGELOV H | 1993 | J Biol Chem1993，268，10： | 1 |
| 8 | Isolation and primary structure of NGAL, a novel protein associated with hu- man neutrophil gelatinase 显示文摘 | KJELDSEN L JOHNSEN AH SENGEL H | 1993 | Biol Chem1993，268，14： | 1 |
| 9 | Isolation and primary structure of NGAL, a novel protein association witn human neutrophil gelatinase 显示文摘 | Kjeldsen L Johnsen AH Sengelcv H | 1993 | J Biol Chem1993，268，10： | 1 |
| 10 | Isolation and primary stueture of NGAL, a novel protein associated with humas neutrophil gelatinase 显示文摘 | Kjeldsen L Johnsen AH Sengelov H | 1993 | J Boil Chem1993，268，10： | 1 |
| 11 | Isolation and primary structure of NGAL a novel protein associated with human neutrophil gelatinase显示文摘 | Kjeldsen L Johnsen AH Sengelcv H | 1993 | J Biol Chem1993，268，10： | 1 |
| 12 | Isolation and primary structure of NGAL, a novel protein associated with human neutro- phil gelatinase 显示文摘 | Kjeldsen L Johnsen AH Sengelcv H | 1993 | J Biol Chem1993，268，10： | 1 |
| 13 | Does off-pump coronary revaseularization confer superior organ protection in re- operative coronary artery surgery? A meta-analysis of observational studies显示文摘 | Sepehripour AH Harling L Ashrafian H | 2014 | J Cardiothorac Surg2014，9，1： | 1 |
| 14 | Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase显示文摘 | Kjeldsen L Johnsen AH Sengelov H | 1993 | J Biol Chem1993，268，10： | 1 |
| 15 | How a dominant retailer might design a purchase contract for a newsvendor-type product with price-sensitive demand显示文摘 | LAU AH L LAU H S WANG Jiancai | 2008 | European Journal of Operational Research2008，190，2： | 1 |
| 16 | Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase显示文摘 | Kjeldsen L Johnsen AH Sengelov H | 1993 | J Boil Chem1993，268，10： | 1 |
| 17 | Isolation and primary structure of NGAL,a novel protein associated with neutrophil gelatinase显示文摘 | Kjeldsen L Johnsen AH Sengelov H | 1993 | Biol Chem1993，268，10： | 1 |
| 18 | Use of radioactive hydrogen for measurement in vivo of total body water显示文摘 | Pace N Kline L Schachman H K et ah Study on body composition Ⅳ | 1947 | J Biol Chem1947，168，： | 1 |
| 19 | Bimodal polyethylene interplay of catalyst and process 显示文摘 | Ah F P Bohm L L Enderle H F | 2001 | Macromolecular S:~m~posia2001，163，1： | 1 |
| 20 | Loss of histochemical identity in mast cells lacking Carboxypeptidase A显示文摘 | Feyerabend TB Hausser H Tietz A Blum C Hellman L Straus AH | 2005 | Mol Cell Biol2005，25，14： | 1 |
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