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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Bone morphogenetic proteins induce apoptosis and growth factor dependence of cultured sympathoadrenal progenitor cells显示文摘 | Song Q Mehler PC Kessler JA | 1998 | Dev Biol1998，19，6： | 1 |
| 3 | Cultured sympatheic neurons synthesize and release the cytokine interleukin-1显示文摘 | Fredin M Bennett MVL Kessler JA | 1992 | Proc Natl Acad Sci LISA1992，89，10： | 1 |
| 4 | Recombinant tis-suetype plasminogen activator versus a novel dosing regimen ofurkinase in acute pulmonary embolism:a randomized comtrolledmulticenter trial显示文摘 | Goldhaber SZ Kessler CM Heit JA | 1992 | J Am Coll Cardiol1992，20，1： | 1 |
| 5 | Transgenic overexpression ol BMP4 increases astroglial and decreases oligodendroglial lineage commitment显示文摘 | Gomes WA Mehler MF Kessler JA | 2003 | Dev Biol2003，255，1： | 1 |
| 6 | Stem cell therapies for spinal cord injury显示文摘 | Sahni V Kessler JA | | 0，，07： | 1 |
| 7 | Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype显示文摘 | Mabie PC Mehler MF Kessler JA | 1999 | J Neurosci1999，19，16： | 1 |
| 8 | Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D 显示文摘 | Conley AJ Gomy MK Kessler JA 2nd | 1994 | J Virol1994，68，11： | 1 |
| 9 | Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid显示文摘 | Rosenbaum DM Rosenbaum PS Gupta A Michaelson MD Hall DH Kessler JA | 1997 | Vision Res1997，37，24： | 1 |
| 10 | The product of hedgehog autoproteolytic cleavage active in local and long-range signalling 显示文摘 | Porter JA von Kessler DP Ekker SC | 1995 | Nature1995，374，6520： | 1 |
| 11 | Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype显示文摘 | Mehler MF Kessler JA | 1999 | J Neurosci1999，19，16： | 1 |
| 12 | The emerging roles of microRNAs in CNS injuries显示文摘 | Bhalala OG Srikanth M Kessler JA | 2013 | Nat Rev Neurol2013，9，6： | 1 |
| 13 | Progenitor cell biology:implications for neural regeneration显示文摘 | Mehler MF Kessler JA | 1999 | Arch Neurol1999，56，7： | 1 |
| 14 | Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system显示文摘 | Chalazonitis A Kessler JA | 2012 | Dev Neurobiol2012，72，6： | 1 |
| 15 | Recombinant tissue type plasminogen activator versus a novel dosing regimen of urokinase in acute pulmonary embolism: a randomized controlled multicenter trial显示文摘 | Goldhaber SZ Kessler CM Heit JA | 1992 | J Am Coll Cardiol1992，20，： | 1 |
| 16 | Determination of preload-recruitable stroke work and elastance by the relationship of arterial blood flow velocity to left ventricular area显示文摘 | Broscheit JA Greim CA Kessler M | 2004 | J Cardiothorac Vasc Anesth2004，18，4： | 1 |
| 17 | Growth factor regulation of neuronal development 显示文摘 | Kessler JA | 1994 | Dev Neurosci1994，16，34： | 1 |
| 18 | Superoxide dismutasea meliorates neuronal death from hypoxia in culture显示文摘 | Rosenbaum DM Kalberg J Kessler JA | 1994 | Stroke1994，25，4： | 1 |
| 19 | Evaluation of the cellular origins of heterotopic ossification 显示文摘 | Kan L Kessler JA | 2014 | Orthopedics2014，37，5： | 1 |
| 20 | Effects of repeated electrical defibrillations on cardiac troponin I levels显示文摘 | Joglar JA Kessler DJ Welch PJ | 1999 | Am J Cardiol1999，83，2： | 1 |
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