| 1 | The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke显示文摘Ischemic stroke continues to be a leading cause of mortality and morbidity in the world. Despite recent advances in the field of stroke medicine, thrombolysis with recombinant tissue plasminogen activator remains as the only pharmacological therapy for stroke patients. However, due to short therapeutic window(4.5 hours of stroke onset) and increased risk of hemorrhage beyond this point, each year globally less than 1% of stroke patients receive this therapy which necessitate the discovery of safe and efficacious therapeutics that can be used beyond the acute phase of stroke. Accumulating evidence indicates that endothelial progenitor cells(EPCs), equipped with an inherent capacity to migrate, proliferate and differentiate, may be one such therapeutics. However, the limited availability of EPCs in peripheral blood and early senescence of few isolated cells in culture conditions adversely affect their application as effective therapeutics. Given that much of the EPC-mediated reparative effects on neurovasculature is realized by a wide range of biologically active substances released by these cells, it is possible that EPC-secretome may serve as an important therapeutic after an ischemic stroke. In light of this assumption, this review paper firstly discusses the main constituents of EPC-secretome that may exert the beneficial effects of EPCs on neurovasculature, and then reviews the currently scant literature that focuses on its therapeutic capacity. | Mansour Alwjwaj Rais Reskiawan AKadir Ulvi Bayraktutan | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 2 | Homotopy study of magnetohydrodynamic mixed convection nanofluid multiple slip flow and heat transfer from a vertical cylinder with entropy generation显示文摘Stimulated by thermal optimization in magnetic materials process engineering,the present investigation investigates theoretically the entropy generation in mixed convection magnetohydrodynamic(MHD)flow of an electrically-conducting nanofluid from a vertical cylinder.The mathematical model includes the effects of viscous dissipation,second order velocity slip and thermal slip,has been considered.The cylindrical partial differential form of the two-component non-homogenous nanofluid model has been transformed into a system of coupled ordinary differential equations by applying similarity transformations.The effects of governing parameters with no-flux nanoparticle concentration have been examined on important quantities of interest.Furthermore,the dimensionless form of the entropy generation number has also been evaluated using homotopy analysis method(HAM).The present analytical results achieve good correlation with numerical results(shooting method).Entropy is found to be an increasing function of second order velocity slip,magnetic field and curvature parameter.Temperature is elevated with increasing curvature parameter and magnetic parameter whereas it is reduced with mixed convection parameter.The flow is accelerated with curvature parameter but decelerated with magnetic parameter.Heat transfer rate(Nusselt number)is enhanced with greater mixed convection parameter,curvature parameter and first order velocity slip parameter but reduced with increasing second order velocity slip parameter.Entropy generation is also increased with magnetic parameter,second order slip velocity parameter,curvature parameter,thermophoresis parameter,buoyancy parameter and Reynolds number whereas it is suppressed with first order velocity slip parameter,Brownian motion parameter and thermal slip parameter. | Nisha Shukla Puneet Rana OAnwar Bég Bani Singh AKadir | 2019 | Propulsion and Power Research2019，8，2： | 0 |
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