维普中文期刊产品整合服务
5篇 您的检索式:作者名="ALBERTINA A"
    题名 作者 年代 出处 被引量
1Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract 显示文摘ALBERTINA A CATHERINE G CHARIES B 1993Life Sci1993,53,16:1
2Input and/or output pruning of composite length FFTs using a DIF-DIT transform decomposition显示文摘Modesto M M Miguel A E Albertina C 2009IEEE Transactions on Signal Processing2009,57,10:1
3imaired hematopoieticstem cell functioning after serial transplantation and normal aging显示文摘Leonie MK Ronald van Os Albertina A 2005Stem Cells2005,23,:1
4Association of UBP 1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P 32 protein显示文摘Alejandro Cassola María Albertina Romaniuk Debora Primrose Gabriela Cervini Iván D’Orso Alberto Carlos Frasch 2015Molecular Microbiology2015,,:1
5Regulation of RNA binding proteins in trypanosomatid protozoan parasites显示文摘Posttranscriptional mechanisms have a critical role in the overall outcome of gene expression. These mechanisms are especially relevant in protozoa from the genus Trypanosoma, which is composed by death threatening parasites affecting people in Sub-saharan Africa or in the Americas. In these parasites the classic view of regulation of transcription initiation to modulate the products of a given gene cannot be applied. This is due to the presence of transcription start sites that give rise to long polycistronic units that need to be processed costranscriptionally by trans-splicing and polyadenylation to give mature monocistronic mRNAs. Posttranscriptional mechanisms such as mRNA degradation and translational repression are responsible for the final synthesis of the required protein products. In this context, RNA-binding proteins(RBPs) in trypanosomes have a relevant role as modulators of mRNA abundance and translational repression by associating to the 3' untranslated regions in mRNA. Many different RBPs have been proposed to modulate cohorts of mRNAs in trypanosomes. However, the current understanding of their functions lacks a dynamic view on the different steps at which these RBPs are regulated. Here, we discuss different evidences to propose regulatory events for different RBPs in these parasites. These events vary from regulated developmental expression, to biogenesis of cytoplasmic ribonucleoprotein complexes in the nucleus, and condensation of RBPs and mRNA into large cytoplasmic granules. Finally, we discuss how newly identified posttranslational modifications of RBPs and mRNA metabolism-related proteins could have an enormous impact on the modulation of m RNA abundance. To understand these modifications is especially relevant in these parasites due to the fact that the enzymes involved could be interesting targets for drug therapy.María Albertina Romaniuk Gabriela Cervini Alejandro Cassola 2016World Journal of Biological Chemistry2016,7,1:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费