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| 1 | Clinical approaches to non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH),leading to fibrosis and potentially cirrhosis,and it is one of the most common causes of liver disease worldwide.NAFLD is associated with other medical conditions such as metabolic syndrome,obesity,cardiovascular disease and diabetes.NASH can only be diagnosed through liver biopsy,but noninvasive techniques have been developed to identify patients who are most likely to have NASH or fibrosis,reducing the need for liver biopsy and risk to patients.Disease progression varies between individuals and is linked to a number of risk factors.Mechanisms involved in the pathogenesis are associated with diet and lifestyle,influx of free fatty acids to the liver from adipose tissue due to insulin resistance,hepatic oxidative stress,cytokines production,reduced very low-density lipoprotein secretion and intestinal microbiome.Weight loss through improved diet and increased physical activity has been the cornerstone therapy of NAFLD.Recent therapies such as pioglitazone and vitamin E have been shown to be beneficial.Omega 3 polyunsaturated fatty acids and statins may offer additional benefits.Bariatric surgery should be considered in morbidly obese patients.More research is needed to assess the impact of these treatments on a long-term basis.The objective of this article is to briefly review the diagnosis,management and treatment of this disease in order to aid clinicians in managing these patients. | Katherine JP Schwenger Johane P Allard | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Parenteral nutrition related hepatobiliary dis- ease in adults显示文摘 | Raman M Allard JP | 2007 | Appl Physiol NutrMetab2007，32，4： | 1 |
| 3 | Parenteral nutrition related hepato-biliary disease in adults 显示文摘 | Raman M Allard JP | 2007 | Appl Physiol Nutr Metab2007，32，4： | 1 |
| 4 | Total enteral nutrition support improves body composition of patients with active Crohn's disease 显示文摘 | Royall D Greenberg GR Allard JP | 1995 | J Parent Enter Nutr1995，19，： | 1 |
| 5 | Breath alkanes as a marker of oxidative stress in different clinical conditions 显示文摘 | Aghdassi E Allard JP | 2000 | Free Radic Biol Med2000，28，6： | 1 |
| 6 | Effects of ascites resolution after successful TIPS on nutrition in cirrhotic patients with refractory ascites显示文摘 | Allard JP Chau J Sandokji K | 2001 | Am J Gastroenterol2001，96，8： | 1 |
| 7 | Quality of life analysis during transition from stationary to portable infusion pump in home parenteral nutrition patients:A Canadian experience显示文摘 | Saqui O Fernandes G Allard JP | 2014 | Nutrition in clinical practice:official publication of the American Society for Parenteral and Enteral Nutrition2014，29，1： | 1 |
| 8 | Total enteral nutrition support improves body composition of patients with acitive Vrohn's disease显示文摘 | Greenberg GR Allard JP | 1995 | JPEN1995，19，： | 1 |
| 9 | Effects of rapid eye movement sleep deprivation on hypoeretin neurons in the hypothalamus of a rat model of depression显示文摘 | Allard JS Tizabi Y Shaffery JP | | 0，，： | 1 |
| 10 | Epidemiology of viral infections and evaluation of the potential benefit of OM-85 BV on the virologic status of children attending day-care cen- ters显示文摘 | Aymard M Chomel JJ Allard JP | 1994 | Respiration1994，61，1： | 1 |
| 11 | Relationship between sodium intake and sleep apnea in patients with heart failure 显示文摘 | Kasai T Arcand J Allard JP | 2011 | J Am Coil Cardio12011，58，： | 1 |
| 12 | Effects of Vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects显示文摘 | Allard JP Aghdassi E Chau J | | 0，，13： | 1 |
| 13 | Relationship between sodium intake and sleep apnea in patients with heart failure显示文摘 | Kasai T Arcand J Allard JP | 2011 | J Am Coll Cardiol2011，58，19： | 1 |
| 14 | Breath alkanes as a marker of oxidative stress in different clinical conditions 显示文摘 | AGHDASSI E ALLARD JP | 2000 | Free Radic Biol Med2000，28，6： | 1 |
| 15 | Total enteral nutrition support improves body composition of patients with active Crohn's disease显示文摘 | Greenberg GR Allard JP | 1995 | JPEN1995，19，： | 1 |
| 16 | Breath alkanes as a marker of oxidative stress in different clinical conditions显示文摘 | Aghdassi E Allard JP | 2000 | Free Radic Biol Med2000，28，6： | 1 |
| 17 | Effects of vitamin E and C supplementation on oxidative stress and viral load in t-IIV- infected subjects 显示文摘 | Allard JP Aghdassi E Chau J | 1998 | AIDS1998，12，13： | 1 |
| 18 | Parenteral nutrition related hepato- biliary disease in adults显示文摘 | Raman M Allard JP | 2007 | Appl Physiol Nutr Metab2007，32，4： | 1 |
| 19 | Breath alkanes as a marker of oxidative stress in different clinical conditions 显示文摘 | Aghdassi E Allard JP | 2000 | Free Radio Biol Med2000，28，： | 1 |
| 20 | Parenteral nutrition related hepato-biliary disease in adults 显示文摘 | Raman M Allard JP | 2007 | Appl Physiol Nutr Metab2007，32，4： | 1 |
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