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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Globular domain of adiponectin promising target molecule for detection of athero- sclerotic lesions显示文摘 | Almer G Saba - Lepek M Haj - Yahya S | 2011 | Biologics2011，5，： | 1 |
| 3 | Autoantibodies to C-reactive protein is a common finding in SLE,but not in primary Sj(o)gren's syndrome,rheumatoid arthritis or inflammatory bowel disease显示文摘 | Sj(o)wall C Eriksson P Almer S | 2002 | Autoimmunity2002，19，3： | 1 |
| 4 | The Effects of Flexible Work Arrangements on Stressors, Burnout, and Behavioral Job Outcomes in Public Accounting显示文摘 | Almer E D S E Kaplan | 2002 | Behavioral Research In Accounting2002，14，： | 1 |
| 5 | High density lipoprotein cho- lesterol level is a robust predictor of lipid peroxidation irrespective of gender, age, obesity, and inflammatory or metabolic biomarkers 显示文摘 | Zelzer S Fuchs N Almer G | 2011 | Clin Chim Acta2011，412，1516： | 1 |
| 6 | Nuchal thickness of subcutaneous adipose tissue is tightly associated with an increased LMW/total adiponectin ratio in obese juveniles显示文摘 | Mangge H Almer G Haj-Yahya S | | 0，，： | 1 |
| 7 | Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model显示文摘 | Kikuchi H Almer G Yamashita S | 2006 | Proc Natl Acad Sci USA2006，103，15： | 1 |
| 8 | Autoantibodies to C-reactive protein(CRP) is a common finding in SLE,but not in primary Sjogrens syndrome,rheumatoid common finding in SLE,but not in primary sjogrens syndrome,rheumatoid arthritis or inflammatory bowel disease显示文摘 | Sjowall C Eriksson P Almer S | 2002 | Autoimmunity2002，19，3： | 1 |
| 9 | A measurement-based statistical model for industrial ultra-wideband channels 显示文摘 | Karedal J Wyne S Almers P | 2007 | IEEE Transactions on Wireless Communications2007，6，8： | 1 |
| 10 | Sampled Data ModelPredictive Control of a Voltage Source Inverter forReduced Harmonic Distortion显示文摘 | Almer S Mariethoz S Morari M | 2013 | IEEE Transactions onControl Systems Technology2013，21，5： | 1 |
| 11 | Phospholipase A2 activity of colonic mucosa in patients with ulcerative colitis显示文摘 | Almer S Franzen L Olaison G | 1991 | Digestion1991，50，34： | 1 |
| 12 | Cross-cultural variation in disease-related concerns among patients with inflammatory bowel disease显示文摘 | LEVENSTEIN S LI Z ALMER S | 2001 | Am J Gastroenterol2001，96，6： | 1 |
| 13 | Spinal cord endoplasmic reticulum stress associated with a micro- somal accumulation of mutant superoxide dismutase - 1 in an ALS model显示文摘 | Kikuchi H Almer G Yamashita S | 2006 | Proc Natl Aead Sci U S A2006，103，： | 1 |
| 14 | Autoantibodies to C-reactive protein(CRP)is a common finding in SLE,but not in primary Sjogren's syndrome,rheumatoid common finding in SLE,but not in primary sjogren's syndrome,rheumatoid arthritis or inflammatory bowel disease显示文摘 | Sjowall C Eriksson P Almer S | 2002 | Autoimmunity2002，19，3： | 1 |
| 15 | A measurementbased statistical modcl for industrial ultra-wideband channels显示文摘 | Karedal J Wyne S Almers P | 2007 | IEEE Transactions on Wireless Communications2007，6，8： | 1 |
| 16 | A measurementbased statistical model for industrial ultra-wideband channels显示文摘 | Karedal J Wyne S Almers P | 2007 | IEEE Transactions on Wireless Communications2007，6，8： | 1 |
| 17 | Preatherosclerosis and adipenectin subfractions in obese adolescents显示文摘 | Mangge H Almer G Haj Y S | 2008 | Obesity (Silver Spring)2008，16，12： | 1 |
| 18 | Autoantibodies to C-reactive protein(CRP) is a common finding in SLE,but not in primary sjogrens syndrome,rheumatoid arthritis or inflammatory bowel disease显示文摘 | Sjowall C Eriksson P Almer S | 2002 | Autoimmunity2002，19，3： | 1 |
| 19 | Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy:possible role of concomitant methotrexate显示文摘 | Pettersson B Almer S Albertioni F | 2002 | Ther Drug Monitor2002，24，： | 1 |
| 20 | Cytokine gene expression at the materno-foetal interface after experimental Neospora caninum infection of heifers at 110 days of gestation显示文摘 | ALMERíA S ARAUJO R N DARWICH L | 2011 | Parasite Immunol2011，33，9： | 1 |
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