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| 1 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | A homogenous linear programming algorithm for the security constrained economic dispatch problem显示文摘 | RABIN A J ALUN H C BRIAN J C | 2000 | IEEE Transactions on Power Systems2000，15，3： | 1 |
| 4 | A homogenous linear programming algorithm for the security constrained economicdispatch problem显示文摘 | Rabin A Jabr Alun H Coonick Brian J Cory | 2000 | IEEE Trans on PS2000，15，3： | 1 |
| 5 | Role of soft pH in the development of enhanced biodegradation of fenamiphos显示文摘 | Walker S A Alun J | 2003 | Applied and Environmental Microbiology2003，19，： | 1 |
| 6 | Noninvasive,online monitoring of the biotransformation by yeast of glucose to ethanol using dispersive Raman spectroscopy and Chemometrics显示文摘 | Adriand S Naheed K Alun J | 1999 | Applied Spectroscopy1999，53，： | 1 |
| 7 | A homogenous linear programming algorithm for the security constrained economic dispatch problem 显示文摘 | Rabin A Jabr Alun H Coonick Brian J Cory | 2000 | IEEE Trans on PS2000，15，3： | 1 |
| 8 | Rapid extraction combined with LC- tandem mass spectrometry ( CREM- LC/MS/ MS) for the determination of ciguatoxins in ciguateric fish flesh 显示文摘 | Richard J Lewis Aijun Yang Alun Jones | 2009 | Toxicon2009，54，： | 1 |
| 9 | Nationalism and Olympism: Towards a Normative Theory of International Sporting Representation 显示文摘 | HYWEL I CARWYN J ALUN H | 2010 | Olympika: The International Journal of Sports Studies2010，19，1： | 1 |
| 10 | A homogenous linear programming algorithm for the security constrained economic dispatch problem显示文摘 | Rabin A Jabr Alun H Coonick Brian J Cory | 2000 | IEEE Transactions on Power Systems2000，15，3： | 1 |
| 11 | Agricultural land protection in China: a case study of local governance in Zhejiang province显示文摘 | Mark W S Richard G K Alun E J | 2001 | Land Use Policy2001，18，2： | 1 |
| 12 | HPLC/tandem electrospray mass spectrometry for the determination of sub-ppb levels of pacific and caribbean ciguatoxins in crude extracts of fish显示文摘 | Lewis R J Alun J Jean-paul V | 1999 | Anal Chem1999，71，1： | 1 |
| 13 | Remarkable inter-and intra-speeies complexity of conotoxins revealed by LC/ MS显示文摘 | Jasmine Davis Alun Jones Richard J Lewis | 2009 | Peptides2009，30，7： | 1 |
| 14 | A System for the Dynamic Characterization of Microstructures 显示文摘 | James S B Alun J H David W | 1997 | Journal of Microelectromechanical Systems1997，6，4： | 1 |
| 15 | The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations显示文摘 | Derval J Gaughan Leo A.J Kluijtmans Sandrine Barbaux Dorothy McMaster Ian S Young John W.G Yarnell Alun Evans Alexander S Whitehead | 2001 | Atherosclerosis2001，，2： | 1 |
| 16 | The Moral Pathologies of Na- tional Sporting Representation at the Olympics显示文摘 | HYWEL I CARWYN J ALUN H | 2012 | Sport Ethics and Philosophy2012，6，2： | 1 |
| 17 | A homogeneous linear programming algorithm for the security constrained economic dispatch problem显示文摘 | Rabih A J Alun H C Brian J C | 2000 | IEEE Trans on Power Systems2000，15，3： | 1 |
| 18 | Hydroxyproline Quantification for the Estimation of Collagen in Tissue Using Multiple Reaction Monitoring Mass Spectrometry 显示文摘 | MICHELLE L C PETER G A ALUN J | 2008 | Journal of Chromatography A2008，1212，： | 1 |
| 19 | Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats 显示文摘 | Ei-Afly A T Aluned A A Fatani A J | 2005 | Pharmacol Res2005，52，3： | 1 |
| 20 | Across the divide: reconciling farm and town views of agriculture-community linkages 显示文摘 | John S Alun E J Matthew A | 2005 | Journal of Rural Studies2005，21，： | 1 |
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