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| 1 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 2 | 金龟子绿僵菌分生孢子暴露在B段紫外光下毒力的降低显示文摘The UV-A and UV-B wavelengths of solar radiation may seriously reduce viability of Metarhizium anisopliae conidia,a fungus used extensively in Brazil for insect pest control.The conidial tolerances to UV-A and UV-B radiation were studied for one isolate(IBCB 425) commercially available product produced on rice grains.Aqueous or oil emulsion conidial suspensions were irradiated for 0(control),2,or 3 h using the solar simulator filtered with diacetate filter to remove UV-C radiation which afforded 652 mW·m-2 in the spectral range of 280~370 nm.The UV tolerance was based on conidial germination(viability) and virulence to Diatraea saccharalis larvae.Conidia formulated with oil emulsion had higher survival after 3 h of UV exposure,but the virulence of the conidia previously exposed to 2 h of UV radiation were similar when oil formulated or not.The mortality of D.saccharalis caterpillars exposed to non-UV-irradiated conidia was greater than that of larvae exposed to irradiated conidia,and the LT50 values were lower for the non-irradiated suspensions than for those irradiated.This apparent reduction in virulence was directly related reduction in viability or delay of germination of UV-irradiated conidia. | Edimara A Francisco Drauzio E N Rangel Newton La Scala Jr José C Barbosa Antnia do C B Correia | 2008 | 安徽农业大学学报2008，35，2： | 2 |
| 3 | Effects of High-Pressure Processing on the Quality of Sea Bass ( Dicentrarchus labrax ) Fillets During Refrigerated Storage显示文摘 | Bárbara Teixeira António Marques Rogério Mendes Amparo Gon?alves Liliana Fidalgo Marise Oliveira Jorge Alexandre Saraiva Maria Leonor Nunes | 2014 | Food and Bioprocess Technology2014，，5： | 1 |
| 4 | Serum immunoglobulin G antibody to Porphyromonas gingivalis in rapidly progressive periodontitis:titer,avidity,and subclass distribution显示文摘 | Whitney C Ant J Monela B | 1992 | Infect Immun1992，60，6： | 1 |
| 5 | Immediate allergic reactions by polyethylene glycol 4000:two cases显示文摘 | Ant o n Giron e s M Roan Roan J de la Hoz B | 2008 | Allergol lmmunopathol (Madr)2008，36，2： | 1 |
| 6 | AtbZIP34 is required for Arabidopsis pollen wall patterning and the control of several metabolic pathways in developing pollen显示文摘 | Antónia Gibalová David Reňák Katarzyna Matczuk Nikoleta Dupl’áková David Cháb David Twell David Honys | 2009 | Plant Molecular Biology2009，，5： | 1 |
| 7 | Crack band theory for fracture of concrete显示文摘 | BA~ANT Z P OH B H | 1983 | Matrriaux et Construction1983，16，3： | 1 |
| 8 | Antimicrobial and safety aspects and biotechnological potential of bacteriocinogenic enterococci isolated from mallard ducks Anas plat yrhynchos显示文摘 | S6NCHEZ J BAS ANT AA GMEZ- SALA B | 2007 | Int J Food Microbiol2007，1173，： | 1 |
| 9 | Crack Band Theory for Frac- ture of Concrete 显示文摘 | Ba~ant Z P Oh B H | 1983 | Materials and Structures1983，16，3： | 1 |
| 10 | The relationship between capsid protein(VP2) sequence and pathogenicity of Aleutian mink disease parvovims(ADV): apossible role for raccoons in the transmission of ADV infovfioos显示文摘 | Oie K L Dun'ant G Wolfinbarger J B | 1996 | J Virol1996，70，2： | 1 |
| 11 | Analysis of lysine clipping of a humanized Lewis-Y specific Ig G antibody and its relation to Fc-mediated effector function显示文摘 | ANTES B AMON S RIZZI A | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，852，12： | 1 |
| 12 | Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma显示文摘 | Vitaliani R Mason W Antes B | 2005 | Ann Neurol2005，58，4： | 1 |
| 13 | In utero undernutrition impairs rat beta-cell development显示文摘 | Garofano A Czernichow P Br6éant B | | 0，，： | 1 |
| 14 | Effects of RHA on autogenous shrinkage of portland cement pastes显示文摘 | Gemma R de S António B R Arlindo G | 2008 | Cement&Concrete Composites2008，30，： | 1 |
| 15 | Lymphocytic plasma cell mastitis masties显示文摘 | Tourn ant B | 1995 | ArchAnta Cytol Pathol1995，43，： | 1 |
| 16 | Quantitative analysis of catalysis and inhibition at horseradish peroxidase monolayers immobilized on an electrode surface显示文摘 | J M Savéant D Dazidi | 2003 | Am Chem Soc2003，125，30： | 1 |
| 17 | Investigation of several PVD coatings for blind hole tapping in austenitic stainless steel显示文摘 | Reiter A E Brunner B Ante M | 2006 | Surface and Coatings Technology2006，，1819： | 1 |
| 18 | Analysis of lysine clipping of a humanized lewis-Y specific IgG antibody and its relation to Fc-mediated effector function 显示文摘 | Antes B Amon S Rizzi A | 2007 | J Chromatogr B2007，852，12： | 1 |
| 19 | Crack band theory for fracture of concrete显示文摘 | OH B H | 1983 | Material and Constructions1983，16，93： | 1 |
| 20 | The relationship between capsid protein (VP2) sequence and pathogenicity of Aleutian mink disease parvovirus (ADV): a possible role for rac- coons in the transmission of ADV infections 显示文摘 | Oie K L Dun'ant G Wolflnbarger J B | 1996 | J Virol1996，70，2： | 1 |
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