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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy显示文摘AIM: To investigate the characteristics of mucosal le-sions and their relation to laboratory data and long-term follow up in breast-fed infants with allergic colitis. METHODS: In this study 31 breast-fed infants were prospectively evaluated (mean age, 17.4 wk) whose rectal bleeding had not ceased after a maternal elimi-nation diet for cow's milk. Thirty-four age-matched and breast-fed infants (mean age, 16.9 wk) with no rectal bleeding were enrolled for laboratory testing as con-trols. Laboratory findings, colonoscopic and histological characteristics were prospectively evaluated in infants with rectal bleeding. Long-term follow-up with differ-ent nutritional regimes (L-amino-acid based formula or breastfeeding) was also included. RESULTS: Iron deficiency, peripheral eosinophilia andthrombocytosis were significantly higher in patients with allergic colitis in comparison to controls (8.4±3.2 μmol/L vs 13.7±4.7 μmol/L, P<0.001; 0.67±0.49 G/L vs 0.33±0.17 G/L, P<0.001; 474±123 G/L vs 376±89 G/L, P<0.001, respectively). At colonosco-py, lymphonodular hyperplasia or aphthous ulceration were present in 83% of patients. Twenty-two patients were given L-amino acid-based formula and 8 contin-ued the previous feeding. Time to cessation of rectal bleeding was shorter in the special formula feeding group (mean, 1.4 wk; range, 0.5-3 wk) when com-pared with the breast-feeding group (mean, 5.3 wk; range, 2-9 wk). Nevertheless, none of the patients ex-hibited rectal bleeding at the 3-mo visit irrespective of the type of feeding. Peripheral eosinophilia and cessa-tion of rectal bleeding after administration of elemental formula correlated with a higher density of mucosal eosinophils. CONCLUSION: Infant hematochezia, after cow's milk allergy exclusion, is generally a benign and probably self-limiting disorder despite marked mucosal abnor-mality. Formula feeding results in shorter time to cessa-tion of rectal bleeding; however, breast-feeding should not be discouraged in long-lasting hematochezia. | Kriszta Molnár Petra Pintér Hajnalka Gyrffy ron Cseh Katalin Eszter Müller András Arató Gábor Veres | 2013 | World Journal of Gastroenterology2013，19，24： | 3 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Adamantinoma of long bones:a long-term follow-up study of 11 cases显示文摘 | Szendroi M Antal I Arató G | 2009 | Pathol Oncol Res2009，15，2： | 1 |
| 5 | 99mTechnetium-labeled methylene diphosphonate uptake in maxillary bone during and after rapid maxillary expansion显示文摘 | Arat Z M Gokalp H Atasever T | 2003 | Angle Orthod2003，73，5： | 1 |
| 6 | Vitiligo after hematopoietic cell transplantation:six cases and review of the literature显示文摘 | Sanli H Akay BN Arat M | 2008 | Dermatology2008，216，4： | 1 |
| 7 | Ridge preservation with the use of Bio-Osscollagen: A 6-month study in the dog 显示文摘 | Arat~jo M Lindhe J | 2009 | Clin Oral Implants Res2009，20，5： | 1 |
| 8 | A phase I dose escalation study of high-dose thiotepa, melphalan and carboplatin (TMCb) followed by autologous peripheral blood stem cell transplantation (PBSCT) in patients with solid tumors and hematologic malignancies 显示文摘 | Ilhan O Mandel NM Arat M Gunel N Celebi H | 2000 | Bone Marrow Transplant2000，25，7： | 1 |
| 9 | Craniofacial growth and skeletal maturation:a mixed longitudinal study显示文摘 | Arat M Koklu A Ozdiler E | 2001 | Eur J Orthod2001，23，4： | 1 |
| 10 | Therapeutic plasma exchange in a single center:Ibni Sina experience显示文摘 | ARSLAN O ARAT M TEK I | 2004 | Transfus Apher Sci2004，30，： | 1 |
| 11 | The displacement of craniofacial reference landmarks during puberty:a comparison of three superimposition methods 显示文摘 | Arat ZM Rubenduz M Akgul AA | 2003 | Angle Orthod2003，73，4： | 1 |
| 12 | Distal embolization after stenting of the vertebral artery:diffusion-weighted magnetic resonance imaging findings 显示文摘 | Canyigit M Arat A Cil BE | 2007 | Cardiovasc Interv Radiol2007，30，2： | 1 |
| 13 | Administration of granulocyte- colony- stimulating factor for allogeneic hematopoietic cell collection may induce the tissue factor- dependent pathway in healthy donors 显示文摘 | Topcuoglu P Arat M Dalva K | 2004 | Bone Marrow Transplant2004，33，2： | 1 |
| 14 | Administration of granulocyte colony stimulating factor for allogeneic hematopoietic cell collection may induce the tissue factor-dependent pathway in healthy donors显示文摘 | Topcuoglu P Arat M Dalva K | 2004 | Bone Marrow Transplant2004，33，2： | 1 |
| 15 | Changes in dentoalveolar and facial heights during early and late growth:a longitudinal study显示文摘 | Arat MZ Rübendüz M | | 0，，： | 1 |
| 16 | The changes in temporomandibular joint disc position and configuration in early orthognathic treatment: a magnetic resonance imaging evaluation显示文摘 | okalp H Arat M Erden I | 2000 | Eur J Orthod2000，22，： | 1 |
| 17 | Orbital venous malformations: Current multidisciplinary treatment approach 显示文摘 | Arat YO Mawad ME Boniuk M | 2004 | Arch Ophthalmol2004，122，8： | 1 |
| 18 | Effects of replacement fluids used for therapeutic plasma exchange on plasma viscosity, and plasma oncotic pressure显示文摘 | Tek I Arslan O Arat M | 2004 | Transfu Apheresls Sci2004，31，2： | 1 |
| 19 | Extramedullary relapse following allogeneic stem cell transplantation in acute promyelocytic leukemia: the role of ATRA 显示文摘 | Ustun C Arat M Celebi H | 2001 | Haematologica2001，86，10： | 1 |
| 20 | Changes in dentoalveolar and fa- cial heights during early and late growth periods:a longi- tudinal study 显示文摘 | Arat ZM Riibendiiz M | 2005 | Angle Orthod2005，75，1： | 1 |
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