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| 1 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 2 | Delineation of epicardial stenosis in patients with microvascular disease using pressure drop coefficient:A pilot outcome study显示文摘AIM To investigate the patient-outcomes of newly developed pressure drop coefficient(CDP) in diagnosing epicardial stenosis(ES) in the presence of concomitant microvascular disease(MVD).METHODS Patients from our clinical trial were divided into two subgroups with:(1) cut-off of coronary flow reserve(CFR) < 2.0;and(2) diabetes.First,correlations were performed for both subgroups between CDP and hyperemic microvascular resistance(HMR),a diagnostic parameter for assessing the severity of MVD.Linear regression analysis was used for these correlations.Further,in each of the subgroups,comparisons were made between fractional flow reserve(FFR) < 0.75 and CDP > 27.9 groups for assessing major adverse cardiac events(MACE:Primary outcome).Comparisons were also made between the survival curves for FFR < 0.75 and CDP > 27.9 groups.Two tailed chi-squared and Fischer's exact tests were performed for comparison of the primary outcomes,and the log-rank test was used to compare the Kaplan-Meier survival curves.P < 0.05 for all tests was considered statistically significant.RESULTS Significant linear correlations were observed between CDP and HMR for both CFR < 2.0(r = 0.58,P < 0.001) and diabetic(r = 0.61,P < 0.001) patients.In the CFR < 2.0 subgroup,the %MACE(primary outcomes) for CDP > 27.9 group(7.7%,2/26) was lower than FFR < 0.75 group(3/14,21.4%);P = 0.21.Similarly,in the diabetic subgroup,the %MACE for CDP > 27.9 group(12.5%,2/16) was lower than FFR < 0.75 group(18.2%,2/11);P = 0.69.Survival analysis for CFR < 2.0 subgroup indicated better event-free survival for CDP > 27.9 group(n = 26) when compared with FFR < 0.75 group(n = 14);P = 0.10.Similarly,for the diabetic subgroup,CDP > 27.9 group(n = 16) showed higher survival times compared to FFR group(n = 11);P = 0.58.CONCLUSION CDP correlated significantly with HMR and resulted in better %MACE as well as survival rates in comparison to FFR.These positive trends demonstrate that CDP could be a potential diagnostic endpoint for delineating MVD with or without ES. | Ullhas Udaya Hebbar Mohamed A Effat Srikara V Peelukhana Imran Arif Rupak K Banerjee | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 3 | Electro-e- lectrodialysis of hydriodie acid in the presence of io dine at elevated temperature 显示文摘 | ONUKI K HWANG G J ARIFAL | 2001 | J Membr Sci2001，192，： | 1 |
| 4 | Appropriate and inappropriate use of fresh frozen plasma显示文摘 | Moiz B Arif F M Hashmi K Z | 2006 | J Pak Med Assoc2006，56，8： | 1 |
| 5 | Pestacin:a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities显示文摘 | HARPER J K ARIF A M FORD E J | 2003 | Tetrahedron2003，59，14： | 1 |
| 6 | PLGA-microsphere mediated clearance of bilirubin in temporarily hyperbilirubinemic rats: An alternate strategy for the treatment of experimental jaundice 显示文摘 | Ahmad N Arif K Faisal S M | 2006 | Biochimica et Biophysica Acta2006，1760，2： | 1 |
| 7 | Pestaein : a I ,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antixidant and antimyeoti activities显示文摘 | Harper J K Arif A M Ford E J | 2003 | Tetrahedron2003，59，14： | 1 |
| 8 | Characterization of Cadmium Selenide Thin Film for Solar Cell Application显示文摘 | Alamgir K Pervaiz T Arif S | | 0，，1： | 1 |
| 9 | Electro-electrodialysis of hydriodic acid using the cation exchange, membrane cross-linked by accelerated electro radiation 显示文摘 | Arifal G Hwang J Qnuki K | 2002 | Mem- br Sci2002，210，1： | 1 |
| 10 | A trinuclear Nickel( 显示文摘 | RUDZKA K ARIF A M BERREAU L M | 2008 | Inorg Chem2008，47，10： | 1 |
| 11 | Roll deformation and stress distribution under thermo-mechanlcal loading in cold rolling显示文摘 | Arif A F M Khan O Sheikh A K | 2004 | Journal of Materials Processing Technology2004，147，： | 1 |
| 12 | Roll Deformation and Stress Distribution under Thermo-mechanical Loading in Cold Rolling显示文摘 | Arif A F M Khan O Sheikh A K | 2004 | Journal of Materials Processing Technology2004，147，2： | 1 |
| 13 | Effects of NP levels, seed rates and row spacing on wheat 显示文摘 | Kakar K M Arif M All S | 2001 | Pakistan Journal of Biological Sciences2001，4，11： | 1 |
| 14 | Roll deformation and stress distribution under thermo-mechanical loading in cold rolling显示文摘 | Arif A F M Ovaisullah Khan Sheikh A K | 2004 | Journal of Materials Processing Technology2004，147，： | 1 |
| 15 | Antioxidant activity andproline content of leaf extracts from Dorystoechas hastate显示文摘 | Arife A K Bengi E Yelda C E | 2008 | Food Chemistry2008，111，： | 1 |
| 16 | Differential cross-utilization of heterologous siderophores by nodule bacteria of Cajanus cajan and its possible role in growth under iron-limited conditions显示文摘 | Arif K Geetha R Akolkar A | 2006 | Applied Soil Ecology2006，34，： | 1 |
| 17 | Molecular characterization and diferential expression of the myo-statin genein channel catfish (Ictalurus punctatus )显示文摘 | Arif M Kocabas H K R and Dunham Z L | 2002 | Biochimica et Biophysica Acta2002，1575，： | 1 |
| 18 | Low blood and vitreal BDNF,LXA4 and altered Th1/Th2 cytokine balance are potential risk factors fordiabetic retinopathy显示文摘 | Kaviarasan K Jithu M Arif Mulla M | 2015 | Metabolism2015，64，9： | 1 |
| 19 | Separation characteristics of fluid flow inside two parallel plates with wavy surface 显示文摘 | Shohel Mahmud Sadrul Islam A K M Mohammad Arif Hasan Mamum | 2002 | Int J Engineering Science2002，40，： | 1 |
| 20 | Complex genetic networks underlying the defensive system of rice (Oryza sativa L, ) to Xanthomonas oryzae pv Oryzae显示文摘 | Li Z K Arif M Zhong D B | 2006 | PNAS2006，103，： | 1 |
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