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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Small intestine bleeding due to multifocal angiosarcoma显示文摘We report a case of an 84-year-old male patient with primary small intestinal angiosarcoma.The patient initially presented with anemia and melena.Consecutive endoscopy revealed no signs of upper or lower active gastrointestinal bleeding.The patient had been diagnosed 3 years previously with an aortic dilation,which was treated with a stent.Computed tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding,leading to operative stent explantation and aortic replacement.However,an aorto-intestinal fistula was not found,and the intestinal bleeding did not arrest postoperatively.The constant need for blood transfusions made an exploratory laparotomy imperative,which showed multiple bleeding sites,predominately in the jejunal wall.A distal loop jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was performed.The histological analysis revealed a lessdifferentiated tumor with characteristic CD31,cytokeratin,and vimentin expression,which led to the diagnosis of small intestinal angiosarcoma.Consequently,the infiltrated part of the jejunum was successfully resected in a subsequent operation,and adjuvant chemotherapy with paclitaxel was planned.Angiosarcoma of the small intestine is an extremely rare malignant neoplasm that presents with bleeding and high mortality.Early diagnosis and treatment are essential to improve outcome.A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity,nonspecific symptoms of altered intestinal function,nonspecific abdominal pain,severe melena,and acute abdominal signs.Therefore,a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim. | Luisa Zacarias Fhrding Arne Macher Stefan Braunstein Wolfram Trudo Knoefel Stefan Andreas Topp | 2012 | World Journal of Gastroenterology2012，18，44： | 4 |
| 3 | Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth显示文摘 | Arne F Anders B | 1987 | Antimicrob Agents Chemother1987，31，5： | 2 |
| 4 | Pore-scale characterization of carbonates using X-ray microtomography显示文摘 | Arns C H Bauget F Limaye A | 2005 | SPEJournal2005，10，4： | 1 |
| 5 | Arenas Versus Muhifunctional Stadiums : Which Do Spectators Prefer? 显示文摘 | ARNE F WOLFGANG M | 2009 | Journal of Sports Economics2009，10，2： | 1 |
| 6 | Cell wall degrading enzymes and the softening of senescent strawberry fruit 显示文摘 | Arnes M F Patchett B J | 1976 | Food Sci1976，41，： | 1 |
| 7 | Weathering and the mobilityof phosphorus in the catchments of and forefields of the Rhoneand Oberaar glaciers,central Switzerland:Implications for theglobal phosphorus cycle on interglacial-glacial timescales显示文摘 | Fllmi K Hosein R Arn K | 2009 | Geochimica et Cosmochimica Acta2009，73，8： | 1 |
| 8 | What Keeps the E-banking Customer Loyal? A Multi-group Analysis of the Moderating Role of Consumer Characteristics on E-loyalty in the Financial Service Industry显示文摘 | ARNE F HORST T | 2006 | Journal of Electronic Commerce Research2006，7，2： | 1 |
| 9 | The value of external anal sphincter electromyography for the diagnosis of multiple system atrophy显示文摘 | TISON F ARNE P SOURGEN C | 2000 | Mov Disord2000，15，6： | 1 |
| 10 | Practical guidelines for diagnosis and treatment of acromegaly 显示文摘 | Cordido F Garcia Arnes JA Marazuela Aspiroz M | 2013 | Endocrinol Nutr2013，60，8： | 1 |
| 11 | 4- Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro 显示文摘 | Arne F Stuart F | 1987 | Antimicrob Agents Chemother1987，31，5： | 1 |
| 12 | Cold tests and modeling of low-Q quasi-optical resonators显示文摘 | Richard P F Arne W F | 2001 | IEEE Trans on Microwave Theory and Techniques2001，49，1： | 1 |
| 13 | Modeling Effects of Forest Canopies on Slope Stability显示文摘 | Richard F Keim Arne E Skangse | 2003 | Hydrological Processes2003，17，7： | 1 |
| 14 | Long distance running increases plantar pressures beneath the metatarsal heads: A barefoot walking investigation of 200 marathon runners显示文摘 | Arne N Frauke F Carolin K | 2008 | Gait Posture2008，27，1： | 1 |
| 15 | Enzyme conversion immunoassay for determining total homocysteine in plasma or serum显示文摘 | Arne L F Ingrid A | 1998 | Clin Chem1998，44，2： | 1 |
| 16 | Microstrip-to-microstrip interconnects with adhesive bonded ribbons for micro-and millimeterwave applications 显示文摘 | Arne F Jacob Helmut Schafer | 1998 | IEEE Trans1998，21，4： | 1 |
| 17 | Pore scale characterizationof carbonates using X-ray microtomography显示文摘 | Arns C H Bauget F Limaye A | 2005 | Society of Petroleum Engineers2005，10，4： | 1 |
| 18 | Morphology-independent representation of motions for interactive human- like animation 显示文摘 | Kulpa R Muhon F Arn aldi B | 2005 | Computer Graphics Forum2005，24，3： | 1 |
| 19 | Further Insights into PerceivedValue and Consumer Loyalty: A “Green” Perspective 显示文摘 | Monika K Arne F Alexander Z | 2011 | Psychology & Marketing2011，28，12： | 1 |
| 20 | Fish oil concentrate: effects on variables related to cardiovascular disease显示文摘 | HUGO F ARNE T H PETER K | 1990 | Am J Clin Nutr1990，52，： | 1 |
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