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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Pancreatic cancer or chronic pancreatitis An answer from PET/MRI image fusion显示文摘 | Alberto M Luca B Arturo C | 2004 | Eur J Nucl Med Mol Imaging2004，31，9： | 1 |
| 3 | Synthesis of 7 -and 10 - spermine conjugates of paclitaxel and 10 -deacetyl -paclitaxel as potential prodrugs显示文摘 | Arturo B Andrea G Eleonora B | 2006 | Tetra Lett2006，47，： | 1 |
| 4 | Pancreatic cancer or chronic pancreatitis? An answer from PET/MRI image fusion显示文摘 | Alberto M Luca B Arturo C | 2004 | Eur J Nucl Med Mol Imaging2004，31，9： | 1 |
| 5 | Integrating conjugative elements as vectors of antibiotic, mercury, and quaternary ammonium compound resistance in marine aquacuhure environments 显示文摘 | ARTURO R B MANUEL L L CARLOS R O | 2012 | Antimicrobial Agents and Chemotherapy2012，56，5： | 1 |
| 6 | Multi-robot visual SLAM using a Rao-Blackwellized particle filter显示文摘 | ARTURO G OSCAR R MONICA B | 2010 | Robotics and Autono- mous Systems2010，58，1： | 1 |
| 7 | Identification of neural stem cells in the adult vertebrate brain显示文摘 | Arturo AB Seri B Doetsch F | 2002 | Brain Research2002，57，6： | 1 |
| 8 | Oxidation kinetics and effect of pH on the degradation of MTBE with Fenton reagent显示文摘 | Arturo A B Dionysios D D Makram T S | 2005 | Water Res2005，39，： | 1 |
| 9 | Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study 显示文摘 | Jesus B Arturo MB Victor S | 2008 | Crit Care2008，12，： | 1 |
| 10 | The Allevia- tion of the Aerodynamic Drag and Wave E{fects of High- speed Trains in Very Long Tunnels显示文摘 | ARTURO B MICHELE M STEFANO S | 2001 | Journal ofWind Engineering and Industrial Aerodynamics2001，89，5： | 1 |
| 11 | Improved optimization formulations for launching nose of incrementally launched prestressed concrete bridges显示文摘 | ARTURO N F JACOBO M D AITOR B | 2011 | Journal of Bridge Engineering2011，16，3： | 1 |
| 12 | The Alleviation of the Aerodynamic Drag and Wave Effects of HighSpeed Trains in Very Long Tunnels显示文摘 | ARTURO B MICHELE M STEFANO S | 2001 | Journal of Wind Engineering and Industrial Aerodynamics2001，89，： | 1 |
| 13 | Incidence,organ dysfunction and mortality in severe sepsis:a Spanish multicentre study显示文摘 | Jesus B Arturo MB Victor S | 2008 | Crit Care2008，12，6： | 1 |
| 14 | Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water显示文摘 | MARIE M M ARTURO A K CLIFFORD A B | 2002 | Journal of Hazardous Materials2002，89，28： | 1 |
| 15 | Effect of Oxygen in a Thin- Film Rotating Disk Photocatalytic Reactor 显示文摘 | Dionysios D D Arturo A B | 2002 | Environ Sci Technol2002，36，17： | 1 |
| 16 | High- performance liquid chromatographic analysis of physio- logical amino acids in human brain tumors by pre-col- umn derivatization with phenylisothiocyanate 显示文摘 | ARTURO B ALESSANDRO B FABIO C | 1999 | Jour- nal of Chromatography B1999，730，： | 1 |
| 17 | Do Insider Trading Laws Work? 显示文摘 | B Arturo | 2005 | European Financial Management2005，11，3： | 1 |
| 18 | A comparative evaluation of interest point detectors and local descriptors for visual SLAM显示文摘 | ARTURO G OSCAR M MONICA B | | 0，，06： | 1 |
| 19 | Effect of burning temperature on water repellency and aggregate stability in forest soils under laboratory conditions显示文摘 | Lorena M. Zavala Arturo J.P. Granged Antonio Jordán Gema Bárcenas-Moreno | 2010 | Geoderma2010，，3： | 1 |
| 20 | An MINLP Model for Biofouling Control in Seawater-cooled Facilities显示文摘 | Fabricio N R Abdullah B M Arturo J G | 2012 | Computers and Chemical Engineering2012，37，10： | 1 |
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