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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Determination of dimethylamine in groundwater by liquid chromatography and precolumn derivatization with 9-fluorenylmethylchloroformate显示文摘 | Margarita Rodriguez Lopez Maria Jose Gonzalez Alvarez Arturo J Miranda Ordieres | 1996 | J Chromatogr A1996，721，： | 1 |
| 3 | Intracapsular tonsillar reduction(partial tonsillectomy),Revi-ving a historical procedure for obstructive sleep disordered breath-ing in children显示文摘 | KOLTAI Peter J SOLARES C Arturo KOEMPEL Jeffery A etal | 2003 | Otolaryngology and head and neck surgery2003，129，5： | 1 |
| 4 | Desulfurization of diesel fuels via r-complexation with nickel(11)-exchanged X-and Y-zeolites 显示文摘 | ARTURO J HERNANDEZ M YANG R T | 2004 | Industrial and engineering chemistry research2004，43，： | 1 |
| 5 | Desulfurization of diesel fuels by adsorption via w-complexation with vapor-phase exchanged Cu ( I )-Y zeolites 显示文摘 | ARTURO J I'IERNANDEZ M YANG R T | 2004 | Journal of the American chemical society2004，126，： | 1 |
| 6 | Desulfurization of transportation fuels with zeolites under ambient conditions 显示文摘 | RALPH T Y ARTURO J H M FRANCES H Y | 2003 | Science2003，，5629： | 1 |
| 7 | Clinoptilolites for nitrogen/methane separation显示文摘 | Jayaraman Ambalavanan Hernandez-Maldonado Arturo J Yang Ralph T | 2004 | Chem Eng Sci2004，59，12： | 1 |
| 8 | Supercontinuum Generation in Photonic Crystal Fibers and Optical Fiber Tapers: a Novel Light Source 显示文摘 | WADSWORTH WILLIAM J ARTURO ORTIGOSA-BLANCH KNIGHT JONATHAN C | 2002 | J Opt Soc Am B2002，19，： | 1 |
| 9 | Peritonitis in continuous ambulatory peritoneal dialysis:cytokines in peritoneal fluid and blood显示文摘 | Enriquez J Klinger J Arturo JA | 2002 | Adv Perit Dial2002，18，： | 1 |
| 10 | Desulfurization of transportation fuels with zeolites under ambient conditions 显示文摘 | RALPH T Y ARTURO J H FRANCES H Y | 2003 | Science2003，301，4： | 1 |
| 11 | WeibuU inference using trimmed samples and prior information显示文摘 | Arturo J and Fernrndez | 2009 | Statistical Papers2009，50，1： | 1 |
| 12 | 显示文摘 | Hernandez M Yang R T | 2003 | Ind Eng Chem Res2003，42，1： | 1 |
| 13 | Highest posterior density estimation frommultiply censored Pareto data 显示文摘 | Arturo J Ferndndez | 2008 | Statistical Papers2008，，49： | 1 |
| 14 | Deter- mination of dimethylamine in groundwater by liquid chromatography and precolumn derivatization with 9-flu- orenylmethyl-chloroformate 显示文摘 | Margarita R L Maria J G A Arturo J M O | 1996 | Chromatogr A1996，721，2： | 1 |
| 15 | Developmental switch in excitability,Ca^2+ and K^+ currents of retinal ganglion cells and their dendritic structure显示文摘 | Andrew J O Arturo P Korenbrot J I | 2000 | J Neurophysiol2000，84，： | 1 |
| 16 | A tenant-based re- source allocation model (or scaling software-as-a-service applica- tions over cloud eomputing infrastructures显示文摘 | J AVIER ESPADAS ARTURO MOLI NA | 2013 | Future Generation Computer Systems2013，29，1： | 1 |
| 17 | Short-term Effects of Experimental Fire for a Soil under Euca- lyptus Forest (SE Australia) 显示文摘 | Arturo J P Granged Antonio Jorddn Lorena M Zavala | 2011 | Geoderma2011，16，7168： | 1 |
| 18 | Desulfurization of transportation fuels by n-eomplexation sorbents: Cu(Ⅰ)-, Ni(Ⅱ)-, and Zn(Ⅱ)-zeolites显示文摘 | ARTURO J H M YANG F H QI G S | 2005 | Applied Catalysis B: Environmental2005，56，12： | 1 |
| 19 | Experimental Analysis and Modeling of the Separation of Triacylglycerol and Free Fatty Acid Mixtures Using Molecular Distillation显示文摘 | Guillermo A M Arturo J G Hugo S G | 2011 | Industrial & Engineering Chemistry Research2011，50，11： | 1 |
| 20 | Peritonitis in continuous ambulatory peritoneal dialysis: cytokines in peritoneal fluid and blood显示文摘 | Enrlquez J Kllnger J Arturo JA | 2002 | Adv Perit Dial2002，18，： | 1 |
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