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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
| 3 | Cellular neural network-based hybrid approach toward automatic image registration 显示文摘 | Arun P V Katiyar S K | 2013 | Journal of Applied Remote Sensing (S1931-3195)2013，7，1： | 1 |
| 4 | State space and SVD based approximation methods for the harmonic retrieval problem显示文摘 | Kung S Y Arun K S Rao D V B | 1983 | Journal of the Optical Society of America1983，73，12： | 1 |
| 5 | State space and SVD based approximation methods for the harmonic retrieval problem显示文摘 | Kung S Y Arun K S Rao D V B | 1983 | Opt Soc Amer1983，73，12： | 1 |
| 6 | Size distribution and source identification of total suspended particulate matter and associated heavy metals in the urban atmosphere of Delhi 显示文摘 | Arun S Jaim V K | 2007 | Chemosphere2007，68，： | 1 |
| 7 | Offshore infor- mation systems project success: the role of social embeddedness and cultural characteristics 显示文摘 | ARUN R MARUPING L M VISWANATH V | 2009 | MIS Quarterly2009，33，3： | 1 |
| 8 | A biodegradable and biocompatible PV A-citric acid polyester with potential applications as matrix for vascular tissue engineering显示文摘 | Lynda V Thomas U Arun S | 2009 | J Mater Sci: Mater Med2009，20，1： | 1 |
| 9 | Biological mechanism of acetate uptake mediated by carbohydrate consumption in excess phosphorus removal systems显示文摘 | ARUN V MINO T MATSUO T | 1988 | Water Research1988，22，5： | 1 |
| 10 | Size distribution and source identification of total suspended particulate matter and associated heavy metals in the urban atmosphere of Delhi 显示文摘 | Arun S Jaim V K | 2007 | Chemosphere2007，，68： | 1 |
| 11 | Optimal Multilevel Thresholds based on Tsallis Entropy Method using Golden Ratio Particle Swarm Optimization for Improved Image Segmentation 显示文摘 | Manikantan K Arun B V | 2012 | Procedia Engineering2012，30，： | 1 |
| 12 | A Terrain-Based Hybrid Approach Towards DEM Interpolation显示文摘 | ARUN P V | 2013 | Annals of GIS2013，19，4： | 1 |
| 13 | endovascular restorative neurosurgery:a novel concept for molecular and cellular therapy of the nervous system显示文摘 | ARUN PAUL AMAR BERISLAV V ZLOKOVIC MICHAEL L APUZZO | 2003 | Neurosurgery2003，52，： | 1 |
| 14 | Effect of hydrogen peroxide on oxidation of copper in CMP slurries containing glycine and Cu ions显示文摘 | TIANBAO D ARUN V VIAML D | 2004 | Electrochimica Acta2004，49，： | 1 |
| 15 | Unusual mechanistic pathway for the synthesis of novel spiro-oxindoles via 3- phenyl-5-isoxazolone ring cleavage by secondary amino acids 显示文摘 | Lakshmi N V Arun Y Perumal P T | 2011 | Tetrahedron Lett2011，52，27： | 1 |
| 16 | A Comparative Analysis of Different DEM Interpolation Methods显示文摘 | ARUN P V | 2013 | The Egyptian Journal of Remote Sensing and Space Sciences2013，16，： | 1 |
| 17 | Biological mechanism of acetate uptake mediated by carbohydrate consumption in excess phosphorus removal systems显示文摘 | Arun V Mino T Matsuo T | 1988 | Water Research1988，22，5： | 1 |
| 18 | An enhanced technique in construction of the discrete drainage network from low resolution spatial database 显示文摘 | Jana R Reshmidevi T V Arun P S | 2007 | Computers and Geosciences2007，33，6： | 1 |
| 19 | Studies on dry sliding wear behaviour of graphite filled glass epoxy composites显示文摘 | BASAVARAJAPPA S ELI ANGOVAN S ARUN K V | 2009 | Materials and Design2009，30，7： | 1 |
| 20 | Site-selective binding and dual mode recognition of serum albumin by a squaraine dye显示文摘 | JISHA V S ARUN K T RAMAIAH D | 2006 | J Am Chem Soc2006，128，18： | 1 |
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