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| 1 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 2 | 3D brain tumor seg-mentation in MRI using fuzzy classification, symmetry analysis and spatially constrained deformable models 显示文摘 | Khotanlou H Colliot O Atif J | 2009 | Fuzzy Sets and Systems2009，160，10： | 1 |
| 3 | Development and Screening of Water-soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury显示文摘 | MacNevin C J Atif F Sayeed I | 2009 | J Med Chem2009，52，19： | 1 |
| 4 | Fuzzy spatial relation ontology for image interpretation显示文摘 | Hudelot C Atif J Bloch I | 2008 | Fuzzy Sets Syst2008，159，15： | 1 |
| 5 | Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians显示文摘 | Atif U Philip A Aponte J | 2008 | Osteoarthritis Cartilage2008，16，10： | 1 |
| 6 | Adenoid cystic carcinoma: A retrospective clinical review 显示文摘 | Atif J Michael P Douglas A | 2001 | Int J Cancer2001，96，3： | 1 |
| 7 | Do lenders favor politically connected finns? 显示文摘 | Khwa J Asim I Atif M | 2005 | Quarterly Journal of Economics2005，120，4： | 1 |
| 8 | Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury 显示文摘 | MaeNevin C J Atif F Sayeed I | 2009 | J Med Chem2009，52，19： | 1 |
| 9 | Explanatory Reasoning for Image Understanding Using Formal Concept Analysis and Description Logics显示文摘 | Atif J Hudelot C Bloeh I | 2013 | IEEE Transactions on Systems Man and Cybernetics : Systems2013，11，99： | 1 |
| 10 | Adrenal gland hematomas in trauma patients 显示文摘 | Atif I Philip J K Mark E | 2004 | Radiology2004，230，3： | 1 |
| 11 | Biological characteristics and host stage preference of mealybug parasitoid Aenasius bambawalei Hayat (Hymenoptera:Encyrtidae)显示文摘 | Zainul-Abdin AM J Gogi MD Muhammad A Fiaz H Abbas SK Hoor S Atif M | | 0，，01： | 1 |
| 12 | Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians显示文摘 | Atif U Philip A Aponte J Woldu EM Brady S Kraus VB | | 0，，： | 1 |
| 13 | Development and screening of water-soluble analogues of progester- one and allopregnanolone in Models of Brain Injury 显示文摘 | MacNevin C J Atif F Sayeed I | 2009 | J Med Chem2009，52，19： | 1 |
| 14 | A strategy for primary high throughput cytotoxicity screening in pharmaceutical toxicology 显示文摘 | Bugelski P J Atif U Mohon S | 2000 | Pharm Res2000，17，10： | 1 |
| 15 | Sequential model-based segmentation and recognition of image structures driven by visual features and spatial relations显示文摘 | FOUQUIER G ATIF J BLOCH I | 2012 | Computer Vision and Image Understanding2012，116，1： | 1 |
| 16 | A constraint propagation approach to structural model based image segmentation and recognition显示文摘 | Nempont O Atif J Bloch I | 2013 | Information Science2013，246，10： | 1 |
| 17 | Sequential model - based segmenta-tion and recognition of image structures driven by visual featuresand relations 显示文摘 | Fouquier G Atif J Bloch I | 2012 | Computer Vision and Image Understaning2012，116，： | 1 |
| 18 | 射线通过抑制内膜低密度脂蛋白聚集影响早期动脉粥样硬化显示文摘骨髓移植常用于研究造血细胞在动脉粥样硬化中的作用。在小鼠骨髓移植后,主动脉弓病变部位变小了。该研究旨在明确骨髓移植对早期动脉粥样硬化的抑制作用,并阐明其机制。方法和结论:对低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)受体基因敲除(Ldlr-/-)小鼠行全身γ射线照射,骨髓重建,并给予6周恢复期。研究升主动脉弓的动脉粥样硬化情况,并与未行骨髓移植的小鼠进行比较。在3、6、12周的高胆固醇膳食后,骨髓移植的小鼠病变部位中性脂类和髓细胞分布减少。骨髓移植后,病变的合并和高度被抑制,但横向增长受抑制较小。 | Ikeda J Scipione CA Hyduk S Althagafi MG Atif J Dick SA Rajora MA Jang E Emoto T MurakamiJ Ikeda N Ibrahim HM Polenz CK Gao X Tai K Jongstra-Bilen J Nakashima R Epelman S Robbins C Zheng G Lee WL MacParland SA Cybulsky MI 陈嘉睿(译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 0 |
| 19 | Study of Bacterial Samples Using Laser Induced Breakdown Spectroscopy显示文摘Laser-induced breakdown spectroscopy(LIBS) technique has been applied to investigate two diflferent types of bacteria,Escherichia coli(B1) and Micrococcus luteus(B2) deposited on glass slides using Spectrolaser 7000.LIBS spectra were analyzed using spectrolaser software.LIBS spectrum of glass substrate was compared with bacteria spectra.Ca,Mg,Na,K,P,S,Cl,Fe,Al,Mn,Cu,C,H and CN-band appeared in bacterial samples in air.Two carbon lines at193.02 nm,247.88 nm and one hydrogen line at 656.28 nm with intensity ratios of 1.9,1.83 and1.53 appeared in bacterial samples Bl and B2 respectively.Carbon and hydrogen are the important components of the bio-samples Uke bacteria and other cancer cells.Investigation on LIBS spectra of the samples in He and Ar atmospheres is also presented.Ni lines appeared only in B2 sample in Ar atmosphere.From the present experimental results we are able to show that LIBS technique has a potential in the identification and discrimination of different types of bacteria. | W A FAROOQ M ATIF W TAWFIK M S ALSALHI Z A ALAHMED M SARFRAZ J P SINGH | 2014 | Plasma Science and Technology2014，16，12： | 0 |
| 20 | Endoscopic therapies of gastroesophageal reflux disease显示文摘在西方的社会的胃的食道的倒流疾病(GERD ) 的高流行为治疗的新形式加速了需要。当前,医药、外科的治疗广泛地在病人和医生之中被接受。新有势力反能分泌的药和为 GERD 的管理的最低限度地侵略的外科的发展目前是治疗的枢轴、大部分接受的途径。然而,最低限度地侵略的治疗革命为 GERD 刺激了几种新内视镜的技术。直到现在,数据被限制,进一步的研究是必要的把各种各样的内视镜的技术的优点和劣势比作医药并且 GERD 的 laparoscopic 管理。新杂志文章和摘要连续地正在被出版。食物药品管理局同意了 3 种形式,这样胃的肠学和外科医生开始正在使用这些技术。进一步的试用和设备精炼将帮助临床医生。这篇文章将给出当前在学习上的各种各样的技术的概述。这评论将为胃的食道的倒流疾病(GERD ) 报导各种各样的内视镜的治疗的功效和耐久性。为这些技术的普遍使用的潜力将也被讨论。在这个话题上用英语出版的文章和摘要从 Pubmed 被检索。由于在各种各样的试用之间的研究和显著差别的有限数字,严格的标准没为一个努力被作由包括仅仅使用了作为对待的基线和目的得分的 off-PPI 的研究避免偏爱的然而,介绍的分享的数据被使用。 | Atif Iqbal Vanessa Salinas Charles J Filipi | 2006 | World Journal of Gastroenterology2006，12，17： | 0 |
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