| 2 | Outcomes of microwave versus radiofrequency ablation for hepatocellular carcinoma:A systematic review and meta-analysis显示文摘BACKGROUND Studies to date comparing outcomes of microwave ablation(MWA)with radiofrequency ablation(RFA)on patients with hepatocellular carcinoma have yielded conflicting results,with no clear superiority of one technique over the other.The aim of this systematic review and meta-analysis was to compare the efficacy and safety of MWA with RFA.AIM To perform a systematic review and meta-analysis comparing the efficacy and safety of MWA with RFA.METHODS A systematic literature search was performed using Ovid Medline,Embase,PubMed,Reference Citation Analysis,Cochrane Central and Cochrane Systematic Review databases,and Web of Science.Abstracts and full manuscripts were screened for inclusion utilising predefined inclusion and exclusion criteria comparing outcomes of MWA and RFA.A random-effects model was used for each outcome.Meta-regression analysis was performed to adjust for the difference in follow-up period between the studies.Primary outcome measures included complete ablation(CA)rate,local recurrence rate(LRR),survival[local recurrence-free survival(LRFS),overall survival(OS)]and adverse events.RESULTS A total of 42 published studies[34 cohort and 8 randomised controlled trials(RCT)]with 6719 patients fulfilled the selection criteria.There was no significant difference in tumour size between the treatment groups.CA rates between MWA and RFA groups were similar in prospective cohort studies[odds ratio(OR)0.95,95%confidence interval(CI)0.28–3.23]and RCTs(OR 1.18,95%CI 0.64–2.18).However,retrospective studies reported higher rates with MWA(OR 1.29,95%CI 1.06–1.57).Retrospective cohort studies reported higher OS(OR 1.54,95%CI 1.15–2.05 and lower LRR(OR 0.67,95%CI 0.51–0.87).No difference in terms of LRFS or 30-d mortality was observed between both arms.MWA had an increased rate of adverse respiratory events when compared to RFA(OR 1.99,95%CI 1.07–3.71,P=0.03).CONCLUSION MWA achieves similar CA rates and as good or better longer-term outcomes in relation to LRR and OS compared to RFA.Apart from an increased rate of respiratory events post procedure,MWA is as safe as RFA. | Myo Jin Tang Guy D Eslick John S Lubel Ammar Majeed Avik Majumdar William Kemp Stuart K Roberts | 2022 | World Journal of Meta-Analysis2022，10，4： | 0 |
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