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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy显示文摘 | Murta CG Moron AF Avila MA Weiner CP | 2002 | Fetal Diagn Ther2002，17，： | 1 |
| 3 | Platelet -derived growth factor in idiopathic pulmonary fibrosis显示文摘 | Antoniades HN Brovo MA Avila RE | 1990 | J Clinlavest1990，86，： | 1 |
| 4 | New therapies for hepatocellular carcinoma显示文摘 | Avila MA Berasain C Sangro B | 2006 | Oncogene2006，25，27： | 1 |
| 5 | Amphiregulin 显示文摘 | Berasain C Avila MA | 2014 | Semin Cell Dev Biol2014，28，： | 1 |
| 6 | New therapies for hepatoc-ellularcarcinoma显示文摘 | Avila MA Berasain C Sangro B | 2006 | Oncogene2006，25，38： | 1 |
| 7 | Selective alteration of native,but not second language articulation in a patient with foreign accent syndrome显示文摘 | Avila C Gonzahz J Pareet MA | | 0，，： | 1 |
| 8 | Functional and morphological changes in the quadriceps muscle induced by eccentric training after ACL reconstruction显示文摘 | Brasileiro JS Pinto OMSF Avila MA | 2011 | Rev Bras Fisioter2011，15，4： | 1 |
| 9 | Reduced in RNA abuncauce of the main enzymes in volvod in methionine metabolism in human liver cirrhosis and hepato cellular carcinoma显示文摘 | Avila MA Berasain C Tortes L | 2000 | J Hepatal2000，33，： | 1 |
| 10 | Re- versible inhibition of chlamydia trachomatis infection in epithelial cells due to stimulation of P2X (4) receptors 显示文摘 | Pettengill MA Marques-da-Silva C Avila ML | 2012 | Infect Immun2012，80，12： | 1 |
| 11 | Platelet-derived growth factor in idiopathic pulmonary fibrosis显示文摘 | Antoniades HN Bravo MA Avila RE | | 0，，04： | 1 |
| 12 | Apop-tosls in trophoblast of patient with recurrent spontaneous abortion of uniden-tified cause 显示文摘 | Vadillo Ortega F Avila Vergara MA Hernandez Guerrero C | 2000 | Gynecol Obstet Mex2000，68，： | 1 |
| 13 | Regulation of rat liver S-adenosylmethionine synthetase during septic shock:role of nitric oxide显示文摘 | Avila MA Mingorance J Martinez-Chantar ML | 1997 | Hepatology1997，25，2： | 1 |
| 14 | Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy显示文摘 | Murta CG Moron AF Avila MA | | 0，，05： | 1 |
| 15 | Role of the yon Hippel-Lindau tumor suppressor gene in the formation of betal-integrin fibrillar adhesions显示文摘 | Esteban-Barragán MA Avila P Alvarez-Tejado M | | 0，，： | 1 |
| 16 | Reduced mRNA abu ndance of the main enzxymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma显示文摘 | Avila MA Berasain C Torres L | 2000 | J Hepatol2000，33，6： | 1 |
| 17 | Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma显示文摘 | Avila MA Berasain C Torres L | 2000 | J Hepatol2000，33，6： | 1 |
| 18 | Up-regulation of the anti-intlammatory adipokine adiponectin in acute liver failure in mice 显示文摘 | Wolf AM Wolf D Avila MA | 2006 | J Hepato12006，44，3： | 1 |
| 19 | Up-regulation of the anti-inflammatory adipokine adiponetin in acute liver failure inmice显示文摘 | WOLF AM WOLF D AVILA MA | 2006 | J Hepatol2006，44，3： | 1 |
| 20 | Functional proteomics of nonalcoholic steatohepatitis: proteins as targets of S-adenosylmethionine显示文摘 | Santamaria E Avila MA Latasa MU | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
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