|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats显示文摘瞄准:在老鼠在导致 caerulein 的胰腺炎和联系肝损伤上处于导致胰腺炎的肝的损坏和象 melatonin,抗坏血酸和 N 乙酰半胱氨酸那样的抗氧化剂代理人的效果调查氧化损害的角色。方法:38 只女 Wistar 老鼠被使用。尖锐胰腺炎(AP ) 被 caerulein 的二 i.p 注射在 2-h 间隔导致(在 100 microg/kg b.wt 的全部的剂量) 。另外的二个组收到了另外的 melatonin (20 mg/kg b.wt ) 或包含 L (+) 维生素酸(14.3 mg/kb.wt.) 和 N 乙酰半胱氨酸(181 mg/kg b.wt ) 的抗氧化剂混合物立即在 caerulein 的每注射前的 i.p。老鼠被斩首杀头 12 h 在 caerulein 的最后注射以后牺牲。胰腺、肝的氧化压力标记被变化在在织物抗氧化剂酶层次,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GPx ) 作为 malondialdehyde (MDA ) 和变化测量的类脂化合物过氧化物的数量评估。组织病理学说的检查用获得系统被执行。结果:肝的房间退化,细胞内部的空泡形成,脉管的拥挤,正弦曲线膨胀和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.001 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。ciner 房间退化,胰腺的浮肿,细胞内部的空泡形成和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.004 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。 导致Caerulein 胰腺并且肝损坏伴有织物 MDA 层次的重要增加( P = 0.01 , P = 0.003 ,分别地)而在猫的重要减少( P = 0.002 , P = 0.003 ,分别地)并且 GPx 活动( P = 0.002 , P = 0.03 ,分别地)。Melatonin 和 L (+) 维生素 acid+N 乙酰半胱氨酸管理显著地减少了在胰的 MDA 层次(P=0.03, P=0.002,分别地) 并且肝(P = 0.007, P = 0.01,分别地) 。这些代理人的管理增加了胰腺、肝的猫和 GPx 活动。Melatonin 显著地增加了胰腺、肝的猫(P = 0.002, P = 0.001,分别地) 并且 GPx 活动(P = 0.002, P = 0.001 ) 。另外, L (+) 维生素酸 +N 乙酰半胱氨酸显著地增加了胰腺的 GPx (P = 0.002 ) 并且肝的猫和 GPx 活动(P = 0.001, P = 0.007,分别地).CONCLUSION:氧化损害不仅在 AP 的致病而且处于导致胰腺炎的肝的损坏起一个重要作用。抗氧化剂代理人象 melatonin 和抗坏血酸 +N 乙酰半胱氨酸那样,能够限制经由恢复织物抗氧化剂酶活动在 AP 期间生产的胰腺、肝的损坏。 | Mukaddes E■refoglu Mehmet Gül Burhan Ate■ Kadir Batoglu Mukadder Ay■e Selimoglu | 2006 | World Journal of Gastroenterology2006，12，2： | 29 |
| 2 | Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey显示文摘Objective:To investigate the antibiotic resistance genes inserted into class I and class 2integrons in Acinetobacler baumannii[A.baumannii)isolates obtained from nine different cities in Turkey.Methods:A collection of 281 A.baumannii clinical isolates were collected from nine diferenl state hospitals in Turkey and were confirmed as A.baumannU by conventional biochemical,API testing and bla_(-OXA-51)specific PCR.The isolates were examined by PCR for existence of class I and2 integron gene cassettes.Results:They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin(90.03%),ciprofloxacin(87.54%),cefepime and trimethoprim/sulfamethoxazole(81.13%).The lowest resistance rates was for cefotaxime(3.55%).class 1 integrons were detected in 6.4%(18/281)of A.baumannii strains and no class 2 integron was detected.The gene casselles of class 1 inlegrons AacCI-AAC(3)l-aadAI,AacCI-aadA1,AAC(3)-I,AAC(3)-I-AAC(3)-I-aadA1,TEM-1.AAC(3)-I-aadA1-AAC(3)-I-AAC(3)-I,AAC(3)-I-AAC(3)-I-AAC(3)-I-aadA1,AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I,AAC(3)-I-aadA1-AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains.The aac genes family were most frequently found integrated into the class 1 inlegrons and it was followed by aadA genes and TEM-1 genes.Conclusions:This is an extensive study on the distribulion of class 1 integron among A.baumannii in Turkey.In addition to these,two new alleles were observed.Their percentage rates of similarity to other cassettes are 95%aadA1(TK A18)and 89%,aadA 1(ANKA3). | Aysegül Copur Cicek Azer Ozad Düzgün Aysegül Saral Tuba Kayman Zeynep Cizmeci Pervin Ozlem Balci Tuba Dal Mehmet Firat Ismail Tosun Yasemin Ay Alitntop Ahmet Caliskan Yelda Yazici Cemal Sandalli | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 3 |
| 3 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 4 | Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons 显示文摘 | Nakayama AY Harms MB Luo L | 2000 | J Neurosci2000，20，14： | 1 |
| 5 | Phenotypic detection of carbapenem-susceptible metallo beta lactamase producing gram-negative bacilli in the clinical laboratory 显示文摘 | Franklin C Liolios L Peleg AY | 2006 | J Clin Microbiol2006，44，9： | 1 |
| 6 | Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder 显示文摘 | Gilboa A Shalev AY Laor L | 2004 | Biol Psychiatry2004，55，： | 1 |
| 7 | Phase II study of ifosfamide,carboplatin,and etoposide in patients with advanced non- small cell lung cancer 显示文摘 | Hsieh RK Chang AY Boros L | 1994 | Am J Clin Oncol1994，17，6： | 1 |
| 8 | Phenotypic Detection of Carbapenem-Susceptible Metallo-β-Lactamase-Producing Gram-Negative Bacilli in the Clinical Laboratory显示文摘 | Franklin C Liolios L Peleg AY | 2006 | J Clin Microbiol2006，44，9： | 1 |
| 9 | Clinic research of Ningdong granule in treating Tourette syndrome显示文摘 | Li AY Ma RP Lv H Zhao L Mu LM Ma HB | | 0，，： | 1 |
| 10 | Diagnostic value of serum cystatin C for evaluation of hepatorenal syndrome显示文摘 | Selda Demirta? Aysun Bozba? Ay?egül Akbay Yasemin Yavuz Levent Karaca | 2001 | Clinica Chimica Acta2001，，2： | 1 |
| 11 | Pelvic embolization for treatment of hemorrhage related to spontaneous and induced abortion显示文摘 | Borgatta L Chen AY Reid SK | 2001 | Am J Obstet Gynecol2001，185，3： | 1 |
| 12 | High concentrations of soluble P-selectin are associated with risk of venous thromboembolism and the P-selectin Thr715 variant显示文摘 | Ay C Jungbaure L V Sailer T | 2007 | Clin Chem2007，53，7： | 1 |
| 13 | Serum α-fetoprotein levels in liver steatosis显示文摘 | Ay?egül Babal? Erman ?akal Tu?rul Purnak ?brahim B?y?ko?lu Ba?ak ?akal Osman Yüksel Seyfettin K?klü | 2009 | Hepatology International2009，，4： | 1 |
| 14 | Differnces between Asian and White Americans,help-seeking and utilization patterns in the Los Angeles aera显示文摘 | Zhang AY Snowden L R &Sue S | 1998 | Journal of Community Psychology1998，26，4： | 1 |
| 15 | Effects of chloride and potassiumchannel blockers on apoptotic cell shrinkage and apoptosis in corticalneurons显示文摘 | Wei L Xiao AY Jin C | 2004 | Pflugers Arch2004，448，3： | 1 |
| 16 | Simulation analysis of conduction block in myelinated axons using three models显示文摘 | Yu L Zhang X Chen AY | 2008 | IEEE Trans on Biomed Eng2008，2，1： | 1 |
| 17 | Comparison between the effects of the phytosterol β-sitosterol and pulp and paper mill effluents on sexually immature rainbow trout显示文摘 | TREMBI AY L KRAAK G V D | 1999 | Environmental Toxicology and Chemistry1999，18，： | 1 |
| 18 | Phenotypic detection of carbap enem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory显示文摘 | Franklin C Liolios L Peleg AY | 2006 | J Clin Microbiol2006，44，9： | 1 |
| 19 | Up-Regulation of Vascular Endothelial Growth Factor by Membrane-type Matrix Metalloproteinase Stimulates HumanGlioma Xenografet Growth and Angiogenesis显示文摘 | Deryugina El Soroceanu L Stmngin AY | 2002 | Cancer2002，，： | 1 |
| 20 | Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity显示文摘 | Abramov AY Canevari L Duchen MR | | 0，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员