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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Volatile composition of aged wine in used barrels of French oak and of American oak显示文摘 | CERDA'N T G RODRIGUEZ MOZAZ S ANCIN AZPILICUETA C | 2002 | Food Res hat2002，35，7： | 1 |
| 3 | Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms显示文摘 | Susana M. Gallego Liliana B. Pena Roberto A. Barcia Claudia E. Azpilicueta María F. Iannone Eliana P. Rosales Myriam S. Zawoznik María D. Groppa María P. Benavides | 2012 | Environmental and Experimental Botany2012，，： | 1 |
| 4 | Oxidative post translational modifications of proteins related to cell cycle are involved in cadmium toxicity in wheat seedlings显示文摘 | Pena L B Barcia R A Azpilicueta C E | 2012 | Plant Sci2012，196，22： | 1 |
| 5 | Accumulation of volatile compounds during ageing of two red wines with different composition显示文摘 | Teresa Garde Cerda n Diego Torrea Goui and Carmen Ancin Azpilicueta | 2004 | Journal of Food Engineering2004，65，： | 1 |
| 6 | Nematode community structure and chemical and Physical Properties in different textural classes of soil in the root zone of 'Williams Pear' 显示文摘 | Azpilicueta C V Aruani M C Vitta L | 2011 | Acta Horticulturae2011，909，： | 1 |
| 7 | A New Ionosphere Monitoring Technology Based on GPS 显示文摘 | BRUNINI C MEZA A AZPILICUETA F | 2004 | Astrophysics and Space Science2004，290，34： | 1 |
| 8 | Binding of oak volatile compounds by wine lees during simulation of wine ageing 显示文摘 | Jimenez - Moreno N Ancin - Azpilicueta C | 2007 | LWT - Food Science and Technology2007，40，4： | 1 |
| 9 | Study and Selection of the Most Appropriate Filler Materials for an A1/Cu Brazing Joint in Cooling Circuits显示文摘 | Berlanga Labari C Albistur Coni A Balerdi Azpilicueta P | 2011 | Materials and Manufacturing Processes2011，26，2： | 1 |
| 10 | Calibration Errors on Experimental Slant Total Electron Content (TEC) Determined with GPS 显示文摘 | CIRAOLO L AZPILICUETA F J BRUNNINI C | 2007 | Journal of Geodesy2007，81，2： | 1 |
| 11 | Volatile composition of aged wine in used barrels of French oak and of American oak显示文摘 | Teresa Garde Cerda'n Sara Rodr'guez Mozaz Carmen Anc'n Azpilicueta | 2002 | Food Research International2002，35，： | 1 |
| 12 | The development of esters in filtered and unfiltered wines that have been aged in oak barrels 显示文摘 | Moreno N J Azpilicueta C A | 2006 | International journal of food science & technology2006，41，2： | 1 |
| 13 | Terlipressin as rescue therapy in hypercyanotic spells of Fallot tetralogy显示文摘 | Azpilicueta Idarreta M Ibarra de la Rosa I Tejero Hernadez MA | 2010 | An Pediatr(Barc)2010，73，1： | 1 |
| 14 | A New Ionosphere Monitoring Technology Based on GPS显示文摘 | BRUNINI C MEZA A AZPILICUETA F | | 0，，03： | 1 |
| 15 | Calibration Errors on Experimental Slant total Electron Content(TEC) Determined with GPS显示文摘 | CIRAOLO L AZPILICUETA F BRUNINI C | | 0，，02： | 1 |
| 16 | Applications of Trichoderma formulations in crop protection显示文摘The choice of active Trichoderma strains is important in designing effective and safe biocontrol applications. Many species of Trichoderma have multiple strategies for fungal antagonism and indirect effects on plant health, such as growth promotion, systemic resistance induction and fertility improvements. Some strains are powerful antibiotic producers, and their suitability for use in biocontrol systems must be carefully assessed. However, many other active strains have no antibiotic capacity, and these are likely to be more useful in food production systems since they have not adverse effects on important groups of beneficial soil organisms. We have assessed the performance of selected naturally occurring Trichoderma strains (singly and in combination) and developed TUSAL, a mixture of Trichoderma harzianum and T. viride that has demonstrated to be effective against major pathogens in sugar beet and horticulture. TUSAL, has been bulked up and tested under field conditions, showing positive effects on precocity and root development, and increasing the crop production in field trials carried out in different pathosystems. The environmental impact of TUSAL strains on beneficial organisms in the environment were assessed before release, and molecular detection methods were developed to monitor the presence and performance of strains in the field. In addition, Trichoderma protein extracts with high glucanase and chitinase activities, have also been obtained from wild type strains and their effectiveness as biofungicides was tested in laboratory and field conditions, defining the concentration of protein necessary to produce fungicide effects. The genes coding for protein production were introduced into suitable organisms for large-scale production in the laboratory, never released to the environment. The effect of these novel biofungicide proteins was studied separately and synergistically with Trichoderma conidia, and with minimal doses of chemical fungicides. Suitable active Trichoderma strains are being registered in the EU by the company NBT. Both Trichoderma strains and proteins are included in formulations patented as biocontrol agents. | Monte E Rodríguez A Rey M Azpilicueta A Gómez M I de la Via G Grondona I Llobell A | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 1 |
| 17 | Calibration Er- rors on Experimental Slant Total Electron Content (TEC) Determined with GPS显示文摘 | Ciraolo L Azpilicueta F Brunini C | 2007 | Journal of Geodesy2007，81，： | 1 |
| 18 | Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms 显示文摘 | GALLEGO S M PENAL B BARCIA RA AZPILICUETA C E IANNONE M F ROSALES E P ZAWOZNIK M S GROPPA M D BENAVIDES M P | 2012 | Environmental and Experimental Botany2012，83，： | 1 |
| 19 | β - Carboline al- kaloids in Peganum harmala and inhibition of human monoamine oxi- dase ( MAO ) 显示文摘 | Herraiz T Gonzatlez D Ancin - Azpilicueta C | 2010 | Food and Chemical Toxicology2010，48，3： | 1 |
| 20 | Volatile composition of aged wine in used barrels of French oak and of American oak 显示文摘 | Cerdan T G Mozaz S R Azpilicueta C A | 2002 | Food Research International2002，35，7： | 1 |
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