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| 1 | Stool-based DNA testing,a new noninvasive method for colorectal cancer screening,the first report from Iran显示文摘AIM:To detect tumor-associated DNA changes in stool samples among Iranian patients with colorectal cancer(CRC)compared to healthy individuals using BAT-26,p16 hypermethylation and long DNA markers.METHODS:Stool DNA was isolated from 45 subjects including 25 CRC patients and 20 healthy individuals using a new,fast and easy extraction method.Long DNA associated with tumor was detected using polymerase chain reaction method.Microsatellite studies were performed utilizing denaturating polyacrylamide gel to determine the instability of BAT-26.Methylation status of p16 promoter was analyzed using methylation-specific PCR(MSP).RESULTS:The results showed a significant difference in existence of long DNA(16 in patients vs 1 in controls,P < 0.001)and p16(5 in patients vs none in controls,P = 0.043)in the stool samples of two groups.Long DNA was detected in 64% of CRC patients;whereas just one of the healthy individuals was positive for Long DNA.p16 methylation was found in 20% of patients and in none of healthy individuals.Instability of BAT-26 was not detected in any of stool samples.CONCLUSION:We could detect colorectal cancer related genetic alterations by analyzing stool DNA witha sensitivity of 64% and 20% and a specificity of 95% and 100% for Long DNA and p16 respectively.A non-invasive molecular stool-based DNA testing can provide a screening strategy in high-risk individuals.However,additional testing on more samples is necessary from Iranian subjects to determine the exact specificity and sensitivity of these markers. | Mohammad Reza Abbaszadegan Alireza Tavasoli Arash Velayati Hamid Reza Sima Hassan Vosooghinia Mehdi Farzadnia Hamid Asadzedeh Mehran Gholamin Ezzat Dadkhah Azadeh Aarabi | 2007 | World Journal of Gastroenterology2007，13，10： | 14 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Serum adipokines might predict liver histology findings in non-alcoholic fatty liver disease显示文摘AIM: To assess significance of serum adipokines to determine the histological severity of non-alcoholic fatty liver disease.METHODS: Patients with persistent elevation in serum aminotransferase levels and well-defined characteristics of fatty liver at ultrasound were enrolled. Individuals with a history of alcohol consumption, hepatotoxic medication, viral hepatitis or known liver disease were excluded. Liver biopsy was performed to confirm nonalcoholic liver disease(NAFLD). The degrees of liver steatosis, lobular inflammation and fibrosis were determined based on the non-alcoholic fatty liver activity score(NAS) by a single expert pathologist. Patients with a NAS of five or higher were considered to have steatohepatitis. Those with a NAS of two or lower were defined as simple fatty liver. Binary logistic regression was used to determine the independent association of adipokines with histological findings. Receiver operating characteristic(ROC) analysis was employed to determine cut-off values of serum adipokines to discriminate the grades of liver steatosis,lobular inflammation and fibrosis. RESULTS: Fifty-four participants aged 37.02 ± 9.82 were enrolled in the study. Higher serum levels of visfatin, IL-8, TNF-α levels were associated independently with steatosis grade of more than 33% [β = 1.08(95%CI: 1.03-1.14), 1.04(95%CI: 1.008-1.07), 1.04(95%CI: 1.004-1.08), P < 0.05]. Elevated serum IL-6 and IL-8 levels were associated independently with advanced lobular inflammation [β = 1.4(95%CI: 1.09-1.8), 1.07(95%CI: 1.003-1.15), P < 0.05]. Similarly, higher TNF-α, resistin, and hepcidin levels were associated independently with advanced fibrosis stage [β = 1.06(95%CI: 1.002-1.12), 19.86(95%CI: 2.79-141.19), 560.72(95%CI: 5.98-5255.33), P < 0.05]. Serum IL-8 and TNF-α values were associated independently with the NAS score, considering a NAS score of 5 as the reference value [β = 1.05(95%CI: 1.01-1.1), 1.13(95%CI: 1.04-1.22), P < 0.05]. CONCLUSION: Certain adipokines may determine the severity of NAFLD histology accurately. | Raika Jamali Mohsen Razavizade Abbas Arj Mohammad Hossein Aarabi | 2016 | World Journal of Gastroenterology2016，22，21： | 7 |
| 4 | Cattle toxoplasmosis in Iran:a systematic review and meta-analysis显示文摘Objective:To analyze and review the overall seroprevalence rate of Toxoplasma gondii(T.gondii) infection in cattle from Iran.Methods:In the current study,data collection(published and unpublished papers,abstracts of national scientific congresses and dissertations) using particular terms was carried out systematically on the following electronic databases like PubMed,Google Scholar,Ebsco,Science Direct,Scopus,Magiran,Irandoc,IranMedex and SID(Scientific Information Database).Results:A total of 22 studies since 1983 to 2012 reporting the seroprevalence of toxoplasmosis in cattle from different regions of Iran met our eligibility criteria.The pooled proportion of toxoplasmosis,using random effect model,among cattle in Iran from over the 30-year period was estimated 18.1%(95%CI:9.9%to 28.2%).Conclusions:This study firstly establishes a crude seroprevalence rate of Toxoplasma infection in cattle which can lead us to understand the condition of eattle toxoplasmosis,which have to take into accounted fur an appropriate and effective prevention and controls.Secondly,it compares and discusses elaborately the role of risk factors including sex,age and breed in the epidemiology of the disease.Thus,it determines gaps and drawbacks in the prior studies which are greatly useful to design more accurate investigations in the future. | Shahabeddin Sarvi Ahmad Daryani Mohammad Taghi Rahimi Mohsen Aarabi Azar Shokri Ehsan Ahmadpour Azadeh Mizani Mahdi Sharif | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，2： | 4 |
| 5 | Negative biomarker-based male fertility evaluation: sperm phenotypes associated with molecular-level anomalies显示文摘基于 Biomarker 的精子分析提高人的不孕的处理并且改善在家畜的繁殖性能。否定基于 biomarker 的途径集中于蛋白质和对有缺点的精子唯一的 ligands,不管他们的词法显型,把自己借给由流动 cytometry (FC ) 的分析。一个主要例子是 spermatid 特定的 thioredoxin SPTRX3/TXNDC8,在原子液泡和有缺点的人的精子的过剩细胞质保留了。不肥沃结合高精液 SPTRX3 当低 SPTRX3 与多重艺术出生被联系了时,多半是更少由帮助繁殖治疗(艺术) 和对周期性的流产敏感的更多怀孕。Ubiquitin,一个小、支持解朊作用的共有原子价 posttranslational 蛋白质修饰词在有缺点的 posttesticular 精子并且在损坏蛋白质总数的表面上被发现, spermiogenic 的 aggresomes 起源。精液 ubiquitin 内容与富饶和常规精液参数,并且与 lectins LCA 有约束力的精子否定地相关(透镜 culinaris 凝集素;揭示改变的精子表面) 并且 PNA (Arachis hypogaea/peanut 凝集素;揭示 acrosomal 畸形性或损坏) 。Postacrosomal 鞘第一次世界大战域有约束力的蛋白质(PAWP ) ,在授精期间在卵母细胞激活含有,从有缺点的人和动物精子宫外或不在。因而,有在不肥沃的夫妇的艺术结果并且与在公牛的富饶的 PAWP 相互关联的 FC 参数。试金基于上述 biomarkers 被合为屏蔽协议的复合 FC 精液,并且 lectins 和 ubiquitin 的表面表示被利用了开发纯化方法由地验证了的基于 nanoparticle 的公牛精液人工的授精试用。这些进展与 FC 技术和 genomics/proteomics-based biomarker 发现的革新变手牵手。 | Peter Sutovsky Mahmoud Aarabi Antonio Miranda-Vizuete Richard Oko | 2015 | Asian Journal of Andrology2015，17，4： | 2 |
| 6 | Role of hMLH1 and E-Cadherin Promoter Methylation in Gastric Cancer Progression显示文摘 | Meysam Moghbeli Omeed Moaven Bahram Memar Hamid Reza Raziei Azadeh Aarabi Ezzat Dadkhah Mohammad Mahdi Forghanifard Fatemeh Manzari Mohammad Reza Abbaszadegan | 2014 | Journal of Gastrointestinal Cancer2014，，1： | 2 |
| 7 | Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis显示文摘 | Ahmad Daryani Shahabeddin Sarvi Mohsen Aarabi Azadeh Mizani Ehsan Ahmadpour Azar Shokri Mohammad-Taghi Rahimi Mehdi Sharif | 2014 | Acta Tropica2014，，： | 2 |
| 8 | Acute cervical traumatic spinal cord injury:MR imaging findings correlated with neurologic outcome-prospective study with 100 consecutive patients显示文摘 | Miyanji F Furlan JC Aarabi B | 2007 | Radiology2007，243，3： | 1 |
| 9 | Acute cervical traumatic spinal cord injury: MR imaging findings correlated with neurologic outcomeprospective study with 100 consecutive patients显示文摘 | Miyanji F Furlan JC Aarabi | 2007 | Radiology2007，243，3： | 1 |
| 10 | Initial closed reduction of cervical spine fracture-dislocation injuries显示文摘 | Gelb DE Hadley MN Aarabi B | | 0，，2： | 1 |
| 11 | Outcome following decompressive craniectomy for malignant swelling due to severe head injury显示文摘 | Aarabi B Hesdorffer DC Ahn ES | 2006 | J of Neurosurgery2006，104，4： | 1 |
| 12 | Enhanced sound localization显示文摘 | Mungamuru B Aarabi P | 2004 | IEEE Transaction on systems man and cybernetics2004，34，3： | 1 |
| 13 | Outcome following decompressive craniectomy for malignant swelling due to severe head injury显示文摘 | Aarabi DHesdorffer Ahn | 2006 | J Neurosurg2006，104，4： | 1 |
| 14 | Acute cervical traumatic spi- nal cord injury: MR imaging findings correlated with neumlogie outcome prospective study with 100 consecutive patients 显示文摘 | Miyanji F Furlan J C Aarabi B | 2007 | Radi- ology2007，243，3： | 1 |
| 15 | Hemorrhagic progression of a contusion after traumatic brain injury:a review显示文摘 | Kurland D Hong C Aarabi B | 2012 | J Neurotrauma2012，29，1： | 1 |
| 16 | Outcome following decompressive craniectomy for malignant swelling due to severe head injury显示文摘 | AARABI B HESDORFFER D C AHN E S | 2006 | J Neurosurg2006，104，： | 1 |
| 17 | Acute cervical traumatic spinal- cord injury: MR imaging findings correlated with neumlogic out- comeprospective study with 100 consecutive patients 显示文摘 | Miyanji F Furlan JC Aarabi A | 2007 | Radiology2007，3，： | 1 |
| 18 | Deep venous throm- bosis and thromboembolism in patients with cervical spinal cord injuries显示文摘 | Dhall SS Hadley MN Aarabi B | 2013 | Neurosurgery2013，72，： | 1 |
| 19 | Hyperextension cervical spine inju- ries and traumatic central cord syndrome 显示文摘 | Aarabi B Kohz M Ibrahimi D | 2008 | Neurosurg Focus2008，25，5： | 1 |
| 20 | Outcome following decompressive craniectomy form alignant swelling due to severe head injury显示文摘 | ] Aarabi B H esdorffer DC Ahn ES | 2006 | Journal of Neurosurgery2006，104，4： | 1 |
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