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| 1 | Structural and near-IR photophysical studies on ternary lanthanide complexes containing poly(pyrazolyl)borate and 1,3-diketonate ligands显示文摘 | DAVIES G M AARONS R J MOTSON G R | 2004 | Dalton Trans2004，8，： | 1 |
| 2 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 3 | Enduring effect of chronic corticosterone treatment on spatial learning,synaptic plasticity,and hippocampal neuropathology in young and mid-aged rats显示文摘 | SHARI R B AARON G H JEMMIFER C L | 1995 | J Neurosci1995，15，1： | 1 |
| 4 | Multiplexed toxin analysis using four colors of quantum dot fluororeagents 显示文摘 | Ellen R G Aaron R C George P A | 2004 | Anlytical Chemistry2004，76，： | 1 |
| 5 | Potentiation of pa- clitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/ protein kinase B (Akt)-mediated signaling pathway 显示文摘 | Dao M N Aaron G C Rishindra R | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，127： | 1 |
| 6 | Effectiveness of parks in protecting tropical biodiversity显示文摘 | Aaron G B Raymond E G Richard E R | 2001 | Science2001，291，5501： | 1 |
| 7 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 8 | Second phase dissolution显示文摘 | AARON H B KOTLER G R | 1971 | Metall Trans1971，2，2： | 1 |
| 9 | Mammalian cell gene mutation assays working group report 显示文摘 | Aaron C S Bolcsfodi G Glatt H R | 1994 | Mutat Res1994，312，3： | 1 |
| 10 | Growth kinetics of precipitates显示文摘 | AARON H B FAINSTAIN D KOTLER G R | 1970 | J Appl Phys1970，41，12： | 1 |
| 11 | Management of Pancreatic Pseudocysts显示文摘 | Hadar Spivak John R Galloway J Richard Amerson Aaron S Fink Gene D Branum Richard D Redvanly William S Richardson Susan J Mauren J Patrick Waring John G Hunter | 1998 | Journal of the American College of Surgeons1998，，5： | 1 |
| 12 | Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin显示文摘 | Shirly P Aaron G R Hongyan L | 2004 | Science2004，304，： | 1 |
| 13 | Diffusion-limited phase transformation: A comparison and critical evaluation of the mathematical approximations 显示文摘 | AARON H B FAINSTEIN D KOTLER G R | 1970 | Journal of Applied Physics1970，41，11： | 1 |
| 14 | Solving models of controlled dynamic planar rigid body systems with frictional contact 显示文摘 | Aaron G Uluc S Alfred A R | 2005 | The International Journal of Robotics Research2005，24，： | 1 |
| 15 | Artificial intelligence for pancreatic cancer detection: Recent development and future direction显示文摘Artificial intelligence(AI)has been increasingly utilized in medical applications,especially in the field of gastroenterology.AI can assist gastroenterologists in imaging-based testing and prediction of clinical diagnosis,for examples,detecting polyps during colonoscopy,identifying small bowel lesions using capsule endoscopy images,and predicting liver diseases based on clinical parameters.With its high mortality rate,pancreatic cancer can highly benefit from AI since the early detection of small lesion is difficult with conventional imaging techniques and current biomarkers.Endoscopic ultrasound(EUS)is a main diagnostic tool with high sensitivity for pancreatic adenocarcinoma and pancreatic cystic lesion.The standard tumor markers have not been effective for diagnosis.There have been recent research studies in AI application in EUS and novel biomarkers to early detect and differentiate malignant pancreatic lesions.The findings are impressive compared to the available traditional methods.Herein,we aim to explore the utility of AI in EUS and novel serum and cyst fluid biomarkers for pancreatic cancer detection. | Passisd Laoveeravat Priya R Abhyankar Aaron R Brenner Moamen M Gabr Fadlallah G Habr Amporn Atsawarungruangkit | 2021 | Artificial Intelligence in Gastroenterology2021，2，2： | 0 |
| 16 | Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects显示文摘OBJECTIVE Over 30% of all new psychoactive substances identified by the UN Office on Drugs and Crime in 2016 were synthetic cannabinoids.The recent emergence of MAM-2201 on the illicit market is troubling because this drug has no precedent in either the scientific or patent literature,and appears to be a novel compound developed specifically as a 'graymarket' drug of abuse bystructurally combining the known synthetic cannabinoids JWH-122 and AM-2201.There is currently no published information regarding the pharmacology of MAM-2201.METHODS The present studies characterized cannabinoid-like effects of MAM-2201 in vitro(interactions with cannabinoid type 1 receptors[CB1 Rs]) and in vivo(in mice and rats).RESULTS In a radioligand binding assay using [3 H]CP55,940 in HEK cell membranes transfected with the CB1 R,MAM-2201(K i=5.4 nmol·L^(-1)),had higher binding affinity than WIN 55,212-2(K i=80 nmol·L^(-1)),and D9-THC(K i=8.3 nmol·L^(-1)).The E max values for MAM-2201 and WIN 55,212-2 in an assay of agonist inhibition of forskolin-stimulated c AMP were 85%(EC50=0.45 nmol·L^(-1)) and 95%,respectively,as compared with the D9-THC E max of 74%.In mice,MAM-2201(0.003-1.0 mg·kg^(-1),IP) produced dose-dependent cannabimimetic effects which were both more potent and more effective than those of D9-THC.MAM-2201 and D9-THC dose-dependently produced hypothermia:ED50=0.287 and 25.4 mg·kg^(-1),analgesia:ED50=0.125 and 29.4 mg·kg^(-1),and catalepsy:ED50=0.301 and18.9 mg·kg^(-1) in adult male CD1 mice.Importantly,MAM-2201 also elicited convulsant effects at a dose of 1.0 mg·kg^(-1) in 8/8 murine subjects.In rats,MAM-2201 produced dose-dependent D9-THC-like interoceptive effects in subjects trained to discriminate 3.0 mg·kg^(-1)(IP) D9-THC from saline.CONCLUSION MAM-2201 binds CB1 Rs with high affinity and agonist efficacy,and functions as a potent cannabinoid agonist in vivo across several complementary measures of cannabinoid activity in two rodent species. | William E FANTEGROSSI Aaron JANOWSKY Amy J ESHLEMAN Lauren N RUSSELL Saki FUKUDA Jyoti GOGOI Cassandra PRIOLEAU Ambuja S BALE Srihari R TELLA Merle G PAULE Takato HIRANITA | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
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