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| 1 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 2 | GREEN SYNTHESIS OF ANTIBACTERIAL CHITOSAN FILMS LOADED WITH SILVER NANOPARTICLES显示文摘An eco-friendly chemical reduction method was successfully used for the preparation of chitosan (CTS) composite films loaded with silver nanoparticles (AgNPs) by self assembly method using poly(ethylene glycol) as both reducing and stabilizing agent. UV-Vis spectra of the prepared chitosan loaded silver nanoparticles (CTSLAg) films reveal that full reduction of silver ions to silver nanoparticles takes place at 90 °C. The effect of reaction conditions on the silver nanoparticles formation was investigated using UV-Vis spectrophotometer. The morphology of the films was tested by scanning electron microscopy (SEM). The DSC curves showed that the CTSLAg film had a favorable compatibility and heat stability. AgNPs were confirmed by XRD and UV-Vis spectroscopy. The TEM findings revealed that the silver nanoparticles synthesized were spherical in shape with uniform dispersal, and by increasing CTS:PEG ratio larger silver nanoparticles could be obtained. The results of antibacterial study reveal that the prepared nanocomposite films exhibited potential inhibition. | Neama A. Reiad Omar E. Abdel Salam Ehab F. Abadir Farid A. Harraz | 2013 | Chinese Journal of Polymer Science2013，31，7： | 2 |
| 3 | Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-mull mice 显示文摘 | Abadir PM Carey RM Siragy HM | 2003 | Hypertension2003，42，60： | 1 |
| 4 | The angiotensin Ⅱ type 1 receptor mediates renal interstitial content of tumor necrosis factor-alpha in diabetic rats显示文摘 | Siragy HM Awad A Abadir P | 2003 | Endocrinology2003，144，6： | 1 |
| 5 | Angiotensin type-2 receptors inhibit renin biosynthesis and angiotensin Ⅱ formation显示文摘 | Xue C Abadir P | 2005 | Hypertension2005，45，1： | 1 |
| 6 | The effect on the bonding strength of orthodontic brackets of fluoride application after etching显示文摘 | Bishara SE Chan D Abadir EA | 1989 | Am J Orthod Dentofacial Orthop1989，95，： | 1 |
| 7 | The effect on the bonding strength of orthodontic brackets of fluoride application after etching显示文摘 | Bishara SE Chan D Abadir EA | 1989 | Am J Orthod Dentofacial Ortbop1989，95，3： | 1 |
| 8 | Arrhythmias in adult congenital heart dis- ease: the year in review显示文摘 | Mondesert B Abadir S Khairy P | 2013 | Curt Opin Cardiol2013，28，3： | 1 |
| 9 | Density funetionals, with an option-pricing application显示文摘 | Abadir K M Rockinger M | 2003 | Econometric Theory2003，19，5： | 1 |
| 10 | Ebstein's Anomaly Assessed by Real-Time 3D Echocardiography显示文摘 | PhilippeA Abadir S Roux D | 2006 | The Annals of Thoracic Surgery2006，82，2： | 1 |
| 11 | Optimization of Alkaline Treatment Conditions of Flax Fiber Using Box–Behnken Method显示文摘 | M. Aly M.S. J. Hashmi A.G. Olabi K.Y. Benyounis M. Messeiry A.I. Hussain E.F. Abadir | 2012 | Journal of Natural Fibers2012，，4： | 1 |
| 12 | Polymeric nano- fibers containing solid nanopartieles prepared by electrospinning and their applications显示文摘 | Barakat N A M Abadir M F Sheikh F A | 2010 | Chemical Engineering Journal2010，156，2： | 1 |
| 13 | Transcatheter closure of perimembranous ventricular septal defects with Amplatzer occluder assessed by real-time three-dimensional echocardiography显示文摘 | Acar P Abadir S Aggoun Y | | 0，，02： | 1 |
| 14 | Novel CdPdS/ PVAc core-shell nanofibers as an effective photocatalyst for organic pollutants degradation 显示文摘 | Unnithan A R Barakat N A M Abadir M F | 2012 | Journal of Molecular Catalysis A: Chemical2012，，： | 1 |
| 15 | Identification and characterization of a functional mitochondrial angiotensin system显示文摘 | Abadir PM Foster DB Crow M | 2011 | Proc Natl Acad Sci USA2011，108，14： | 1 |
| 16 | The effect on the bonding strength of orthodontic brackets of fluoride application after etching显示文摘 | Bishara S E Chan D Abadir E A | 1989 | Am J Orthod Dento facial Ortbop1989，95，3： | 1 |
| 17 | Testing Joint Hypotheses when one of the Alternatives is One-sided 显示文摘 | ABADIR K M DISTASO W | 2007 | Karim Maher Abadir2007，140，2： | 1 |
| 18 | Transcatheter closure of perimembranous ventricular septal defects with Amplatzer occluder assessed by real-time three-dimensional echocardiography显示文摘 | Abadir S Aggoun Y | 2007 | Eur J Echocardiogr2007，8，2： | 1 |
| 19 | The effects on the bonding strength of fluoride application after etching显示文摘 | Bishara SE Chan D Abadir EA | 1989 | Am J Orthod Dentofac Orthop1989，95，： | 1 |
| 20 | Significant persistent ductus artefiosus in infants less or equal to 6 kg: percutaneous closure or surgery? 显示文摘 | Abadir S Boudjemline Y Rey C | 2009 | Arch Cardiovasc Dis2009，102，： | 1 |
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