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| 1 | Differential Effect of Artemisinin Against Cancer Cell Lines显示文摘The present study aims at defining the differential cytotoxicity effect of artemisinin toward P815(murin mastocytoma)and BSR(kidney adenocarcinoma of hamster)cell lines.Cytotoxicity was measured by the growth inhibition using MTT assay.These in vitro cytotoxicity studies were complemented by the determination of apoptotic DNA fragmentation and Annexin V-streptavidin-FITC assay.Furthermore,we examined the in vitro synergism between artemisinin and the chemotherapeutic drug,vincristin.The in vivo study was investigated using the DBA2/P815(H2d)mouse model.While artemisinin acted on both tumor cell lines,P815 was much more sensitive to this drug than BSR cells,as revealed by the respective IC50 values(12 lM for P815 and 52 lM for BSR cells).On another hand,and interestingly,apoptosis was induced in P815 but not induced in BSR.These data,reveal an interesting differential cytotoxic effect,suggesting the existence of different molecular interactions between artemisinin and the studied cell lines.In vivo,our results clearly showed that the oral administration of artemisinin inhibited solid tumor development.Our study demonstrates that artemisinin caused differential cytotoxic effects depending not only on the concentration and time of exposure but also on the target cells. | Mounir Tilaoui Hassan Ait Mouse Abdeslam Jaafari Abdelmajid Zyad | 2014 | Natural Products and Bioprospecting2014，4，3： | 8 |
| 2 | Medicinal plant products targeting quorum sensing for combating bacterial infections显示文摘Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances. | Abdelhakim Bouyahya Nadia Dakka Abdeslam Et-Touys Jamal Abrini Youssef Bakri | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 7 |
| 3 | The use of hydrogeochemical analyses and multivariate statistics for the characterization of thermal springs in the Constantine area, Northeastern Algeria显示文摘This paper deals with the results of a hydrogeochemistry study on the thermal waters of the Constantine area, Northeastern Algeria, using geochemical and statistical tools. The samples were collected in December2016 from twelve hot springs and were analyzed for physicochemical parameters(electric conductivity, p H,total dissolved solids, temperature, Ca, Mg, Na, K, HCO_3,Cl, SO_4, and SiO_2). The waters of the thermal springs have temperatures varying from 28 to 51 °C and electric conductivity values ranging from 853 to 5630 l S/cm. Q-mode Cluster analysis resulted in the determination of two major water types: a Ca–HCO_3–SO_4 type with a moderate salinity and a Na–K–Cl type with high salinity. The plot of the major ions versus the saturation indices suggested that the hydrogeochemistry of thermal groundwater is mainly controlled by dissolution/precipitation of carbonate minerals, dissolution of evaporite minerals(halite and gypsum), and ion exchange of Ca(and/or Mg) by Na. The Gibbs diagram shows that evaporation is another factor playing a minor role. Principal Component Analysis produced three significant factors which have 88.2% of totalvariance that illustrate the main processes controlling the chemistry of groundwaters, which are respectively: the dissolution of evaporite minerals(halite and gypsum), ion exchange, and dissolution/precipitation of carbonate minerals. The subsurface reservoir temperatures were calculated using different cation and silica geothermometers and gave temperatures ranging between 17 and 279 °C. The Na–K and Na–K-Ca geothermometers provided high temperatures(up to 279 °C), whereas, estimated geotemperatures from K/Mg geothermometers were the lowest(17–53 °C). Silica geothermometers gave the most reasonable temperature estimate of the subsurface waters overlap between 20 and 58 °C, which indicate possible mixing with cooler Mg groundwaters indicated by the Na–K–Mg plot in the immature water field and in silica and chloride mixing models. The results of stable isotope analyses(δ^(18) O and δ~2 H) suggest that the origin of thermal water recharge is precipitation, which recharged from a higher altitude(600–1200 m) and infiltrated through deep faults and fractures in carbonate formations. They circulate at an estimated depth that does not exceed 2 km and are heated by a high conductive heat flow before rising to the surface through faults that acted as hydrothermal conduits.During their ascent to the surface, they are subjected to various physical and chemical changes such as cooling by conduction and change in their chemical constituents due to the mixing with cold groundwaters. | Riad Kouadra Abdeslam Demdoum Nabil Chabour Rebiha Benchikh | 2019 | Acta Geochimica2019，38，2： | 3 |
| 4 | Numerical and experimental study of Boussinesq wall horizontal turbulent jet of fresh water in a static homogeneous environment of salt water显示文摘This paper investigates a numerical and experimental study about buoyant wall turbulent jet in a static homogeneous environment. A light fluid of fresh water is injected horizontally and tangentially to a plane wall into homogenous salt water ambient. This later is given with different values of salinity and the initial fractional density is small, so the applicability of the Boussinesq approximation is valid. Since the domain temperature is assumed to be constant, the density of the mixture is a function of the salt concentration only. Mathematical model is based on the finite volume method and reports on an application of standard k- ? turbulence model for steady flow with densimetric Froude numbers of 1-75 and Reynolds numbers of 2 000-6 000. The basic features of the model are the conservation of mass, momentum and concentration. The boundaries of jet body, the radius and cling length are determined. It is found that the jet spreading and behavior depend on the ratio between initial buoyancy flux and momentum, i.e., initial Froude number, and on the influence of wall boundary which corresponds to Coanda effect. Laboratory experiments were conducted with photographic observations of jet trajectories and numerical results are described and compared with the experiments. A good agreement with numerical and experimental results has been achieved. | BELCAID Aicha LE PALEC Georges DRAOUI Abdeslam | 2015 | Journal of Hydrodynamics2015，27，4： | 2 |
| 5 | Hydrogeochemical characteristics of groundwater and quality assessment for the purposes of drinking and irrigation in Bougaa area,Northeastern Algeria显示文摘In the northern part of Algeria,the intensive exploitation of groundwater resources and pollution has considerably affected the aquifer water quality,especially in rural areas where groundwater is the main source of water supply for most uses.This study was performed to evaluate the groundwater quality and its suitability for drinking and irrigation purposes through the hydrogeochemical study on the groundwater in Bougaa region(Northeastern Algeria).Fourteen groundwater samples were collected and analyzed for p H,T,EC,TDS,and major ions.Most samples are suitable for drinking based on the permissible limits of the Bureau of Indian standards(Indian standard specification for drinking water(IS 10500:2012),but only 35%of the samples are good enough for drinking purposes based on the water quality index of the groundwater.Assessment of groundwater samples from various parameters and methods such as'Electrical conductivity,Sodium adsorption ratio,Soluble sodium percentage,Magnesium adsorption ratio,Residual sodium carbonate,Permeability index,Kelly’s ratio,Wilcox’s diagram,and US salinity laboratory classification'showed that groundwater in the area is chemically suitable for irrigation uses.The Piper trilinear diagram suggests that the groundwater mainly belongs to the hydrochemical facies Ca–Mg–Cl and Na–Cl.The combination of ionic ratios,Gibbs plots,and saturation indices show that water–rock interaction,particularly the dissolution of carbonate,evaporation minerals,and ion exchange processes affects hydrogeochemistry of the area.Additional processes such as evaporation and anthropogenic pollution from various sources can also have major impacts on groundwater salinity. | Riad Kouadra Abdeslam Demdoum | 2020 | Acta Geochimica2020，39，5： | 2 |
| 6 | A unified artificial neural network architecture for active power 显示文摘 | ABDESLAM D O WIRA P MERCKLE J | 2007 | Industrial Electronics2007，54，1： | 1 |
| 7 | Real‐Time Contact Force Sensing for Pulmonary Vein Isolation in the Setting of Paroxysmal Atrial Fibrillation: Procedural and 1‐Year Results显示文摘 | ELOI MARIJON SAMIA FAZAA KUMAR NARAYANAN BENOIT GUY‐MOYAT ABDESLAM BOUZEMAN RUI PROVIDENCIA FREDERIC TREGUER NICOLAS COMBES AGUSTIN BORTONE SERGE BOVEDA STEPHANE COMBES JEAN‐PAUL ALBENQUE | 2014 | J Cardiovasc Electrophysiol2014，，2： | 1 |
| 8 | A unifiedartificial neural network architecture for active power filters显示文摘 | ABDESLAM D O’ WIRA P MERCKLE J | 2007 | IEEE Trans on Industrial Electronics2007，54，1： | 1 |
| 9 | A Unified Artificial Neural Network Architecture for Active Power Filters显示文摘 | Abdeslam D O Wira P Merckle J | 2007 | Industrial Electronics2007，54，1： | 1 |
| 10 | Improving the performance of image classification by Hahn moment invariant 显示文摘 | SAYYOURI M ABDESLAM H | 2013 | Journal of the Optical Society of America A : Optics and Image Science and Vision2013，30，11： | 1 |
| 11 | Adaline for online symmetrical components and phase-angles identification in transmission lines显示文摘 | YOUSFI F L ABDESLAM D O BOUTHIBA T | 2012 | IEEE Transactions on Power Delivery2012，27，3： | 1 |
| 12 | Fast computation of separable two-dimensional discrete invariant moments for image classification显示文摘 | Abdeslam H Mhamed S Hassan Q | 2015 | Pattern Recognition2015，48，： | 1 |
| 13 | Extraction and modeling of algerian rosemary essential oil using supercritical CO2 :Effect of pressure and temperature 显示文摘 | AHMED Z ABDESLAM - HASSAN M OUASSILA L | 2012 | Energy Procedia2012，18，： | 1 |
| 14 | Transfers of Collidal Silica from Water Organic Solvents of Intermediate Polarities显示文摘 | Abdeslam K Erlend K | 1998 | Colloid Interface Science1998，，197： | 1 |
| 15 | Agomelatine(S 20098) antagonizes the penile erections induced by the stimulation of 5-HT2C receptors in Wistar rats显示文摘 | Abdeslam Chagraoui Philippe Protais Thierry Filloux Elisabeth Moca?r | 2003 | Psychopharmacology2003，，1： | 1 |
| 16 | A double step synthesis of mesoporous micrometric spherical MSU-X silica particles显示文摘 | Cedric B Arie V D L Abdeslam E M etal | 1999 | Chem Commun1999，20，： | 1 |
| 17 | MPLS security: an approach for unicast and multicast environments显示文摘 | Sahel Alouneh Abdeslam En-Nouaary Anjali Agarwal | 2009 | annals of telecommunications2009，，5： | 1 |
| 18 | Metamodeling and multicriteria analysis for sustainable and passive residential building refurbishment: A case study of French housing stock显示文摘For the energy-related issues that the world is facing nowadays,the renovation of the building stock is one of the major challenges.The objective of this study is to present an approach that helps to develop a multi-criteria decision support tool dedicated to the rehabilitation of sustainable and passive energy housing by integrating heating energy needs,economic,social and environmental criteria throughout the life cycle stages of the building.The methodology consists of developing metamodels to predict heating energy needs from polynomial regression,design of experiments method and thermo-aeraulic simulations of building behavior.This metamodel is used to carry out a combinatorial study of real technical solutions.The methodology was applied to a real-life existing building located in La Rochelle city(France)based on an in-situ energy diagnosis.Three multicriteria analysis methods were studied and compared:weighted sum,Min-Max and Pareto concept.Furthermore,technical constraints as well as owner preferences and performance constraints have been studied.Optimal technical solutions have been obtained in order to meet the various criteria studied.In addition,window shading and natural ventilation have been proposed to reduce the thermal discomfort rate in summer.This study was extended to all French regions.Finally,this method can be transformed into a decision support tool which will be useful for architects,engineers and stockholders. | Zaid Romani Abdeslam Draoui Francis Allard | 2022 | Building Simulation2022，15，3： | 1 |
| 19 | Brain Drain in Developing Countries显示文摘 | Fre' de' ric Docquier Olivier Lohest Abdeslam Marfouk | 2007 | The World Bank Economic Review2007，13，： | 1 |
| 20 | Aggregates and hydrogels prepared by self-assembly of amphiphilic copolymers with surfactants显示文摘 | Wu Xiaohan Abdeslam El Ghzaoui Li Suming | 2012 | Journal of Colloid and Interface Science2012，374，： | 1 |
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