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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 3 | Natural fibre high- density polyethylene and lead oxide composites for radi- ation shielding 显示文摘 | Abdo A E Ali M A M Ismail M R | 2003 | Radiation Physics and Chemistry2003，66，3： | 1 |
| 4 | Thirteen week toxic study of D-a-tocopheryl acetate (vitamin E) in Fischer 344 rats显示文摘 | Abdo K M Rao G Montgomery C A | 1986 | Food and Chemical Toxicology1986，24，： | 1 |
| 5 | A numerical study of structural damage detection using changes in the rotation of mode shapes 显示文摘 | Abdo M A B Hori M | 2002 | Journal of Sound and Vibration2002，251，2： | 1 |
| 6 | Metabolites of medicinalplants furanoeremophilanes and other constituents from Senecio canescens显示文摘 | ABDO S DEBERNARDI M MARINONI G | 1992 | Phytochemistry1992，31，11： | 1 |
| 7 | Continuous venovenous hemodiafiltration in patients with multiple organ dysfunction syndrome in an intensive care unit显示文摘 | Abdo AA Castellanos R Rocha M | 2012 | MEDICC Rev2012，14，3： | 1 |
| 8 | Fermi LAT Detection of Pulsed Gamma-Rays from the Velalike pulsars PSR J1048-5832and PSR J2229+6114显示文摘 | Abdo A A Ackermann M Ajello M | | 0，，： | 1 |
| 9 | Disorders of orgasm and ejaculation in men显示文摘 | McMahon CG Abdo C Incrocci L Perelman M Rowland D Waldinger M Xin ZC | 2004 | Sex Med2004，1，1： | 1 |
| 10 | The First Fermi Large Area Telescope Catalog of Gammaray Pulsars显示文摘 | Abdo A A Ackermann M Ajello M | | 0，，： | 1 |
| 11 | Physicomeehanical evaluation of polypropylene, polyester, and polytetrafluoroethylene meshes for inguinal hernia repair显示文摘 | DEEKEN C R ABDO M S FRISELLA M M | 2011 | Journal of the American College of Surgeons2011，212，1： | 1 |
| 12 | Damage detection in plate-like struc- tures using high-order mode shape derivatives 显示文摘 | Abdo M A B | 2012 | In- ternational Journal of Civil and Structure Engineering2012，2，3： | 1 |
| 13 | Management of distal anterior cerebral artery aneu- rysms: part I: anatomic variations and clinical presentation显示文摘 | Abdo M Guinto G Contreras R | 2011 | Contemp Neurosurg2011，33，： | 1 |
| 14 | Effects of annealing on the crystallinity and microparacrystallite size of Kevlar 49 fibres 显示文摘 | Hindeleh A M Abdo S M | 1989 | Polymer1989，30，2： | 1 |
| 15 | R,Natural fibre high-density polyethylene and lead oxide composites for radiation shielding显示文摘 | El-Sayed Abdo A Ali M A M Ismail M | 2003 | Radiation Physics and Chemistry2003，66，3： | 1 |
| 16 | Catalytic Activity and Stability of Anionic and Cationic Water Soluble Cobalt(Ⅱ) Tetraarylporphyrin Complexes in the Oxidation of 2-Mercapto-Ethanol by Molecular Oxygen显示文摘 | Gerges S Abdo M | 2005 | J Mol Catal A2005，240，12： | 1 |
| 17 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities 显示文摘 | Sch ti tte Ursel M E Abdo Z Bent St J | 2008 | Applied Microbiology and Biotechnology2008，80，3： | 1 |
| 18 | Effects of annealing on the crystal- linity and microparacrystallite size of Kevlar 49 fibres显示文摘 | HindeIeh A M Abdo S M | 1989 | Poly- mer1989，30，2： | 1 |
| 19 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities 显示文摘 | Schtitte U M E Abdo Z Bent S J | 2008 | Applied Microbiology and Bio- technology2008，80，3： | 1 |
| 20 | The First Fermi Large Area Telescope Catalog of Gammaray Pub sars显示文摘 | ABDO A A ACKERMANN M AJELLO M | 2010 | ApJS2010，187，： | 1 |
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