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| 1 | Probe measurement of electrostatic fields in particle-bearing gas flows显示文摘 | V. I. Buzanov V. K. Abramyan T. F. Grishina L. E. Krapivin | 1978 | Measurement Techniques1978，，5： | 1 |
| 2 | Probe measurement of electrostatic fields in particle-bearing gas flows显示文摘 | Buzanov V I Abramyan V K Grishina T F | 1978 | Measurement Techniques1978，21，5： | 1 |
| 3 | Variation of enzyme activity of soil under the influence of natural and anthropogenic factors显示文摘 | ABRAMYAN SA | 1993 | Eurasian Soil Science1993，25，： | 1 |
| 4 | Effect of liquid dielectrics on the efficiency of silicon solar cells 显示文摘 | Abramyan Y A Karamyan G G Murodyan A A | 1999 | Semiconductors1999，33，12： | 1 |
| 5 | Effect of liquid dielectrics on the efficiency of silicon solar cells 显示文摘 | Abramyan Y A Karamyan G G Murodyan A A | 1999 | Semiconductors1999，33，12： | 1 |
| 6 | Endotoxin adsorption using polymyxin B immobilized fiber cartridges in severe sepsis patients following cardiac surgery显示文摘 | Yaroustovsky M Abramyan M Krotenko N | 2014 | Int J Artif Organs2014，37，4： | 1 |
| 7 | A pilot study of selective lipopolysaccharide adsorption and coupled plasma filtration and adsorption in adult patients with severe sepsis 显示文摘 | Yaroustovsky M Abramyan M Krotenko N | 2015 | Blood Purif2015，39，13： | 1 |
| 8 | Charged-particle multiplicity measurement in proton–proton collisions at $\sqrt{s}=7$ ?TeV with ALICE at LHC显示文摘 | K. Aamodt N. Abel U. Abeysekara A. Abrahantes?Quintana A. Abramyan D. Adamová M. M. Aggarwal G. Aglieri?Rinella A. G. Agocs S. Aguilar?Salazar Z. Ahammed A. Ahmad N. Ahmad S. U. Ahn R. Akimoto A. Akindinov D. Aleksandrov B. Alessandro R. Alfaro?Molina A. | 2010 | The European Physical Journal C (-)2010，，3： | 1 |
| 9 | Charged-particle multiplicity measurement in proton–proton collisions at $\sqrt{s}=0.9$ and 2.36?TeV with ALICE at LHC显示文摘 | K. Aamodt N. Abel U. Abeysekara A. Abrahantes?Quintana A. Abramyan D. Adamová M. M. Aggarwal G. Aglieri?Rinella A. G. Agocs S. Aguilar?Salazar Z. Ahammed A. Ahmad N. Ahmad S. U. Ahn R. Akimoto A. Akindinov D. Aleksandrov B. Alessandro R. Alfaro?Molina A. | 2010 | The European Physical Journal C (-)2010，，1： | 1 |
| 10 | Probe Measurement of Electrostatic Fields in Particle-bearing Gas Flows 显示文摘 | Buzanov V I Abramyan V K Grishina T F | 1978 | Measurement Techniques1978，21，5： | 1 |
| 11 | Kinetics of the neutralization of static electricity in apparatus containing two-phase systems of gas and solid particles 显示文摘 | Abramyan V K Kastal'Skaya N N Pichakhchi G I | 1980 | Journal of Engineering Physics and Thermophysics1980，38，3： | 1 |
| 12 | Identification and optimization of a potent and highly selective D3 dopamine receptor agonist显示文摘OBJECTIVE Dopamine receptors(DRs) are involved in the development and treatment of many neuropsychiatric disorders.Currently available dopaminergic drugs modulate both DRD2 and DRD3,leading to side effects and uncertainty as to the roles each DR subtype plays physiologically.Our lab employed high throughput screening paradigms to discover highly selective modulators for the DRD3.METHODS The NIH Molecular Libraries Program 400,000 + small molecule library was screened using the Discove Rx Path Hunter?β-arrestin assay for compounds that activate the DRD3 without effects on the DRD2.Confirmation and counter-screens assessed selectivity and mechanisms of action.We identified 62 potential agonists,and chose the most promising to perform a structure-activity relationship(SAR) study to increase potency while maintaining selectivity.The lead compound identified through this process,ML417,was also characterized using bioluminescence resonance energy transfer(BRET)-based β-arrestin recruitment and G-protein activation assays as well as p-ERK assays.Potential neuroprotective properties of this compound were assessed using a SHSY5 Y neuronal cell model.RESULTS ML417 displays potent,DRD3-selective agonist activity in multiple functional assays.Binding and functional GPCR screens(>165 receptors) show ML417 has limited cross-reactivity with other GPCRs.ML417 also displays superior(compared to the reference compound pramipexole),dose-dependent protection against a decrease in neurite length induced by 10 μmol·L^(-1) of the neurotoxin,6-hydroxydopamine,in the SHSY5 Y cell model.CONCLUSION We have discovered and characterized ML417,a potent and highly selective DRD3 agonist.This compound will be useful as a research tool,and may prove useful as a therapeutic drug lead. | Amy E MORITZ R Benjamin FREE Warren WEINER Muzna BACHANI Trevor DOYLE Noel SOUTHALL Marc FERRER Jonathan A JAVITCH Joseph STEINER Ara ABRAMYAN Lei SHI Jeffrey AUBé Kevin FRANKOWSKI David R SIBLEY | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
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