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| 1 | Regulation of hepatic blood flow:The hepatic arterial buffer response revisited显示文摘The interest in the liver dates back to ancient times when it was considered to be the seat of life processes. The liver is indeed essential to life,not only due to its complex functions in biosynthesis,metabolism and clearance,but also its dramatic role as the blood volume reservoir. Among parenchymal organs,blood flow to the liver is unique due to the dual supply from the portal vein and the hepatic artery. Knowledge of the mutual communication of both the hepatic artery and the portal vein is essential to understand hepatic physiology and pathophysiology. To distinguish the individual importance of each of these inflows in normal and abnormal states is still a challenging task and the subject of on-going research. A central mechanism that controls and allows constancy of hepatic blood flow is the hepatic arterial buffer response. The current paper reviews the relevance of this intimate hepatic blood flow regulatory system in health and disease. We exclusively focus on the endogenous interrelationship between the hepatic arterial and portal venous inflow circuits in liver resection and transplantation,as well as inflammatory and chronic liver diseases. We do not consider the hepatic microvascular anatomy,as this has been the subject of another recent review. | Christian Eipel Kerstin Abshagen Brigitte Vollmar | 2010 | World Journal of Gastroenterology2010，16，48： | 49 |
| 2 | Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin显示文摘 | Meier C Spitschak A Abshagen K e: al | 2014 | J Pathol2014，234，3： | 1 |
| 3 | Clinical pharmacologic investigations with carvedilot,a new P-blocher with direct vasodilator activity显示文摘 | Von Moellendorff E Abshagen V Akpan W | 1986 | Clic Pharmacol Ther1986，39，： | 1 |
| 4 | Foxf1 siRNA Delivery to Hepatic Stellate Cells by DBTC Lipoplex Formulations Ameliorates Fibrosis in Livers of Bile Duct Ligated Mice显示文摘 | Kerstin Abshagen Malte Brensel Berit Genz Kira Roth Maria Thomas Volker Fehring Ute Schaeper Brigitte Vollmar | 2015 | Current Gene Therapy2015，，3： | 1 |
| 5 | Influence of sperm surface antibodies on spontaneous pregnancy rates显示文摘 | Abshagen K Behre HM Nieschlag E | 1998 | Fertil Steril1998，70，2： | 1 |
| 6 | Role of the perforin/granzyme cell death pathway in D-Gal/LPS-induced inflammatory liver injury显示文摘 | Kuhla A Eipel C Abshagen K | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，5： | 1 |
| 7 | Role of the per- forin/granzyme cell death pathway in D - Gal/LPS - in- duced inflammatory liver injury 显示文摘 | Kuhla A Eipel C Abshagen K | 2009 | Am J Physiol Gas- trointest Liver Physiol2009，296，5： | 1 |
| 8 | Role of the perforin/ in D-Gal/LPS-induced infla- mmatory liver injury显示文摘 | Kuhla A Eipel C Abshagen granzyme cell death pathway K | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，5： | 1 |
| 9 | First dose on effects and pharmacokinetics of isosorbide 5-mononitrate in normal man显示文摘 | ABSHAGEN U SPOERL R S | 1982 | Eur J Clin Pharmacol1982，19，： | 1 |
| 10 | Hepatocellular apoptosis is mediated by TNFα-dependent Fas/FasLigand cytotoxicity in a murine model of acute liver failure显示文摘 | Angela Kuhla Christian Eipel Nikolai Siebert Kerstin Abshagen Michael D. Menger Brigitte Vollmar | 2008 | Apoptosis2008，，12： | 1 |
| 11 | RAGE blockade and hepatic microcirculation in experimental endotoxaemic liver failure显示文摘 | A. Kuhla J. Norden K. Abshagen M. D. Menger B. Vollmar | 2013 | Br J Surg2013，，9： | 1 |
| 12 | Clinical pharmacologic investigations with carvedilol,a new β blocher with direct vasodilator activity显示文摘 | Von Moellendorff E Abshagen U Akpan W | 1986 | Clin Pharmcol Ther1986，39，： | 1 |
| 13 | Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice 显示文摘 | Le Minh K Klemm K Abshagen K | 2007 | Am J Pathol2007，170，： | 1 |
| 14 | Paradoxical expres- sion of vasoregulating mediators in the small-for-size-liver 显示文摘 | Cantre D Eipel C Abshagen K | 2006 | Eur Surg Res2006，，： | 1 |
| 15 | Limited potential of resolvin D1 in treatment of cholestatic liver fibrosis显示文摘Background:Several studies suggest a role for EPA-and DHA-derived pro-resolving mediators like resolvins in reversing metabolic and inflammatory disturbances seen in various chronic diseases.Here,we investigated the effects of resolvin D1(RvD1)on bile duct ligation(BDL)-induced cholestatic liver injury.Methods:Mice were treated daily with RvD1 or 0.1%ethanol(control)from the day of BDL until the final observation time points.Blood and liver tissue were collected 2,5 and 14 days after BDL for different analyses.Results:RvD1 treatment of mice had no impact on the extent of cholestatic liver injury upon BDL,neither in the acute phase nor in the progressive state of liver fibrosis.Although RvD1 treatment resulted in a significantly reduced activity of hepatic stellate cells as well as reduced deposition of extracellular matrix 2 days after BDL,mice were not protected from inflammation and further fibrosis progression.Conclusions:These data indicate that RvD1 has a limited therapeutic potential to treat cholestatic liver diseases,as it has no significant impact on regression of hepatic necroinflammation and fibrotic changes in bile duct-ligated mice. | Kerstin Abshagen Alexander Hartmann Laura Grüner Marie Liebig Brigitte Vollmar | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 1 |
| 16 | Clinical pharmacologic investigations with carvedilol, a new β-blocher with direct vasodilator activity显示文摘 | Von Moellendorff E Abshagen U Akpan W | 1986 | Clin Pharmacol Ther1986，39，： | 1 |
| 17 | First dose on effects and pharmacokinetics of isosorbide 5-mononitrate in normal man显示文摘 | Abshagen V Spoerl RS | 1982 | Eur J Clin Pharmacol1982，19，： | 1 |
| 18 | In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute N-anoBone显示文摘 | Abshagen K Schrodi I Gerber T | 2009 | J Biomed Mater Res A2009，91，2： | 1 |
| 19 | Clinical pharmacologic investigations with carvedilol, a new β-blocker with direct vasodilator activity 显示文摘 | Von Mollendorff E Abshagen U Akpan W | 1986 | Clin Pharmacol Ther1986，39，6： | 1 |
| 20 | A critical appraisal of the hemodynamic signal driving liver regeneration显示文摘 | Abshagen K Eipel C Vollmar B | 2012 | Langenbecks Arch Surg2012，397，4： | 1 |
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