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| 1 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 2 | Microstructure characterization of an ultrahigh carbon and boron tool steel processed by different routes显示文摘 | Jimenez J A Frommeyer G | 1996 | Materials Science and Engineering1996，206，2： | 1 |
| 3 | Web-based three-dimensional virtual body Structures:W3D-VBS显示文摘 | Temkin B Acosta E Hatfield P | 2002 | J Am Med Inform Assoc2002，9，5： | 1 |
| 4 | Mechanical properties of two ultrahigh carbon-boron tool steels显示文摘 | JIMENEZ J A FROMMEYER G ACOSTA P | 1995 | Materials Science and Engineering A1995，202，12： | 1 |
| 5 | A practical large-scale synthesis of 17-acetoxy-11 - ( 4-N, N-dimethylaminophenyl)-19-norpregna-4, 9-diene-3,20-dione ( CDH-2914 ) 显示文摘 | RAO P N ACOSTA C K BAHR M L | 2000 | Steroids2000，65，7： | 1 |
| 6 | (AC)23[Z-2] polymorphism of the aldose reductase gene and fast progression of retinopathy in Chilean type 2 diabetes显示文摘 | Olmos P Futers S Acosta AM | | 0，，03： | 1 |
| 7 | Conductivity Studies of Solid Polymer Electrolytes Based on Polyethers and Polyphosphazene Blends显示文摘 | Martin A P J Acosta J L | 1998 | Journal of Applied Polymer Science1998，70，11： | 1 |
| 8 | Appearance modeling of 11C PiB PET images:characterizing amyloid deposition in Alzheimer′s disease,mild cognitive impairment and healthy aging显示文摘 | Fripp J Bourgeat P Acosta O | | 0，，： | 1 |
| 9 | Behavior of an Aeromonas hydrophila aroa live vaccine in water microcosms显示文摘 | Vivas J Carracedo B Riano J Razquin B E Lopez- Fierro P Acosta F Naharro G Villena A J | 2004 | AppL Environ Microbiol2004，70，5： | 1 |
| 10 | Biosorption of copper by Paenibacillus polymyxa cells and their exopolysaccharide 显示文摘 | ACOSTA M P VALAMAN E LEITE S G F | 2005 | World Jouranal of Microbiology & Biotechnology2005，21，： | 1 |
| 11 | Therapeutic hypothermia : past, present, and fu- ture显示文摘 | Varon J Acosta P | 2008 | Chest2008，133，5： | 1 |
| 12 | Trends in prevalence of fatal surgical dis- eases at forensic autopsy显示文摘 | Acosta S Krantz P | 2007 | ANZ J Surg2007，7，8： | 1 |
| 13 | Incidence and survival rate of hepatic retransplantation in a series of 300 orthotopic liver transplants 显示文摘 | Sanchez - Bueno F Acosta F Ramirez P | 2000 | Transplant Proc2000，32，8： | 1 |
| 14 | Therapeutic hypothermia: past, present, and future 显示文摘 | Varon J Acosta P | 2008 | Chest2008，133，5： | 1 |
| 15 | Microstructural characteri-zation of an ultrahigh carbon and boron tool steel processed by dif Ferent rutes显示文摘 | Acosta P Jimenez J A Frommeyer G | 1996 | Materials Science and Engineering A1996，206，13： | 1 |
| 16 | Epidemiology, risk and prognostic factors in mesenteric venous thrombosis显示文摘 | Acosta S Alhadad A Svensson P | 2008 | Br J Surg2008，95，10： | 1 |
| 17 | Microstructare Characterization of an Ultrahigh Carbon and Boron Tool Steel Processed by Different Routes显示文摘 | Acosta P Jimenez J A Frommeyer G | 1996 | Materials Science and Engineering1996，206，2： | 1 |
| 18 | Effect of storage time and tem- perature on the serum phase of cultured cream cheese 显示文摘 | Kindstedt P S Acosta L | 2005 | Aust J DairyTechnol2005，60，1： | 1 |
| 19 | Treatment of uterine myoma with 5 or 10mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trial显示文摘 | Josep Ll. Carbonell Esteve Rita Acosta Yasmiriam Pérez Rosa Campos Aleta Valle Hernández Carlos Sánchez Texidó | 2012 | European Journal of Obstetrics and Gynecology2012，，2： | 1 |
| 20 | japon- icum infections: a proof-of-concept study显示文摘 | van Dam GJ Odermatt P Acosta L Evaluation of banked urine samples for the detection of circulating anodic and cathodic antigens in Schistosoma mekongi and S | 2015 | Acta Trop2015，，： | 1 |
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