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| 1 | Non-surgical treatment of hilar cholangiocarcinoma显示文摘Cancer of the biliary confluence also known as hilar cholangiocarcinoma(HC)or Klatskin tumor,is a rare type of neoplastic disease constituting approximately 40%-60%of intrahepatic malignancies,and 2% of all cancers.The prognosis is extremely poor and the majority of Klatskin tumors are deemed unresectable upon diagnosis.Most patients with unresectable bile duct cancer die within the first year after diagnosis,due to hepatic failure,and/or infectious complications secondary to biliary obstruction.Curative treatments include surgical resection and liver transplantation in highly selected patients.Nevertheless,very few patients are eligible for surgery or transplant at the time of diagnosis.For patients with unresectable HC,radiotherapy,chemotherapy,photodynamic therapy,and liver-directed minimally invasive procedures such as percutaneous image-guided ablation and intra-arterial chemoembolization are recommended treatment options.This review focuses on currently available treatment options for unresectable HC and discusses future perspectives that could optimize outcomes. | Riccardo Inchingolo Fabrizio Acquafredda Valentina Ferraro Letizia Laera Gianmarco Surico Alessia Surgo Alba Fiorentino Stefania Marini Nicola de'Angelis Riccardo Memeo Stavros Spiliopoulos | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 5 |
| 2 | Evidenees for iNOS Expression and Nitric Oxide Production in the Human Macrophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endoer Metabol Disord2003，3，3： | 1 |
| 3 | Longitudinal assessment of levo-thyroxine therapy for congenital hypothyroidism: relationship with aetiology, bone maturation and biochemical features显示文摘 | Delvecchio M Faienza MF Acquafredda A | 2007 | Horm Rcs2007，68，3： | 1 |
| 4 | Evidences for iNOS expression and nitric oxide production in the human maerophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003，3，3： | 1 |
| 5 | Ferruginous concretions in a Late Cretaceous karst bauxite: Composition and conditions of formation显示文摘 | Mongelli G Acquafredda P | 1999 | Chemical Geology1999，158，34： | 1 |
| 6 | Provenace and tectonic implications of heavy minerals in Pliocene-Pleistocene siliciclastic sediments of the southern Apennines,Italy显示文摘 | Acquafredda P Fornelli A Piccarreta G | 1997 | Sedimentary Geology1997，113，： | 1 |
| 7 | Evidences for iNOS expression and nitric oxide production in the human macrophages显示文摘 | PANARO MA BRANDONISIO O ACQUAFREDDA A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003，3，3： | 1 |
| 8 | Evidences for iNOS expression and nitricoxide production in the human macrophages显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003，3，3： | 1 |
| 9 | Provenance and tectonic implications of heavy minerals in Pliocene-Pleistocene siliclastic sediments of southern Apennines显示文摘 | Acquafredda P Fornelli A Piccarrcta G | 1997 | Sedimen tary Geology1997，，113： | 1 |
| 10 | Severe hypogly- cemia during successful treatment of diffuse hemangiomatosis with propranolol 显示文摘 | Bonifazi E Acquafredda A Milano A | 2010 | Pediatric Dermatology2010，27，10： | 1 |
| 11 | Evidences for iNOS expression and nitric oxide production in the human macrophages显示文摘 | Panaro MA Brandonisio 0 Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003，3，： | 1 |
| 12 | Biological role of the N-formyl peptide receptors 显示文摘 | Panaro MA Acquafredda A Sisti M | 2006 | Immunopharmacol Immunotoxicol2006，28，： | 1 |
| 13 | Evi- dences for iNOS expression and nitric oxide production in the human macrophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metahol Disord2003，3，3： | 1 |
| 14 | Longitudinal assessment of levo-thyroxine therapy for congenital hypothyroidism: relationship with aetiology, bone maturation and biochemical features显示文摘 | Delvecchio M Faienza MF Acquafredda A | 2007 | Horm Res2007，68，3： | 1 |
| 15 | Provenance and tectonic implications of heavy minerals in Pliocene--Pleistocene silicielastic sediments of the southern Apennines, Italy 显示文摘 | Acquafredda P Fornelli A Piecarreta G | 1997 | Sedimentary Geology1997，113，： | 1 |
| 16 | Evidences for iNOS expression and nitric oxide production in the human macrophages显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003，3，30： | 1 |
| 17 | Evidences for iNOS expression and nitric oxide production in the human macrophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metab Disord2003，3，： | 1 |
| 18 | Severe hypoglyce- mia during successful treatment of diffuse hemangiomatosis with prapranolol 显示文摘 | Bonifazi E Acquafredda A Milano A | 2010 | Pediatr Dermatol2010，27，2： | 1 |
| 19 | Evidences for iNOS ex- pression and nitric oxide production in the human macrophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curt Drug Targets Immune Endocr Metabol Disord2003，3，30： | 1 |
| 20 | Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-κB activation in Caco-2 and SW480 human colon cancer cells显示文摘 | Maria Antonietta Panaro Vito Carofiglio Angela Acquafredda Pasqua Cavallo Antonia Cianciulli | 2012 | British Journal of Nutrition2012，，： | 1 |
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