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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Bee Parasitic Mite Syndrome(II):The Role of Varroa Mite and Virues 显示文摘 | Hung A C F Adams J R Shimanuki H | 1995 | American Bee Journal1995，12，： | 2 |
| 5 | Nefopam, a nonsedative benzoxazocine analgesie, selectively reduees the shivering threshold in unanesthetized subjects 显示文摘 | Alfnnsi P Adam F Passard A | 2004 | Anesthesiology2004，，1： | 1 |
| 6 | The environmental fate of phthalate esters: a literature review显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 7 | The environmental fate of phthalate esters: a literature review 显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 8 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 9 | Sur-rogate end points in heart failure trials显示文摘 | Gheorghiade M Adams K F Jr Gattis W A | 2003 | Am Heart J2003，145，2： | 1 |
| 10 | Pathophysiology of contrast-induced nephropathy显示文摘 | TUMLIN J STACUL F ADAM A | 2006 | Am J Cardiol2006，，： | 1 |
| 11 | Surface characterization of artificial corrosion layers on copper alloy reference materials显示文摘 | Constantinides I Adriaeus A Adams F | 2002 | Appl Surf Sci2002，189，： | 1 |
| 12 | Hygrothermal microstress in a unidirectional composite exhibiting inelastic materials behavior显示文摘 | Adams D F Miller A K | 1977 | Journal of Composite Materials1977，11，： | 1 |
| 13 | A Light Interception Method for Measuring Row Crop Ground Cover显示文摘 | Adams J E A G F | 1977 | Soil Science Society of America Journal1977，41，4： | 1 |
| 14 | Novel high capacitance materials:BaTiO3:La and CaCu3Ti4O12显示文摘 | West A R Adams T B Morrison F D | 2004 | J Euro Cera Soci2004，24，： | 1 |
| 15 | Tannin in skins and seeds of Cabernet Sanvignon, Syrah, and Pinot noir berries during ripening显示文摘 | HARBERTSON J F KENNEDY J A ADAMS D O | 2002 | American Journal of Enology and Viticulture2002，53，1： | 1 |
| 16 | Strategies to reduce the risk of contras-induced nephropathy显示文摘 | Stacul F Adam A Becker CR | 2006 | Am J Cardiol2006，98，6： | 1 |
| 17 | Design of steel plate shear walls considering inelastic drift demand 显示文摘 | Ghosh S Adam F Das A | 2009 | Journal of Constructional Steel Research2009，65，7： | 1 |
| 18 | A Light Interception Method for Measuring Row Crop Ground Cover显示文摘 | Adams J E A G F | 1977 | Soil Science Society of America Journal1977，41，4： | 1 |
| 19 | Aquatic toxicity of eighteen phthalate esters显示文摘 | Staples A Adams W J Parkerton T F | 1997 | Enuironmentol Toxicology and Chemistry1997，16，5： | 1 |
| 20 | Alkylphenol ethoxylates in the environment显示文摘 | Naylor C G Mieure J P Adams W J Weeks J A Castaldl F J Ogle L D Romano R R | 1992 | American Oil Chemists Society1992，69，： | 1 |
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