|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 2 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 3 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 4 | Outpatient Laparoscopic Cholecystectomy: Patient Outcomes After Implementation of a Clinical Pathway显示文摘 | J. Forrest Calland Koji Tanaka Eugene Foley Viktor E. Bovbjerg Donna W. Markey Sonia Blome John S. Minasi John B. Hanks Marcia M. Moore Jeffery S. Young R. Scott Jones Bruce D. Schirmer Reid B. Adams | 2001 | Annals of Surgery2001，，5： | 1 |
| 5 | Development of an experimental capa- bility to produce controlled blade tip/shroud rubs at engine speed显示文摘 | Barton J Dunn M G Manwaring S Young G Adams M Adams M | 2005 | The Journal of Turbomachinery- Transactions of the ASME2005，4，： | 1 |
| 6 | Systematic application of multiplex PCR enhances the detection of bacteria, parasites, and viruses in stool samples显示文摘 | Gary N. McAuliffe Trevor P. Anderson Mary Stevens Jacqui Adams Robyn Coleman Patalee Mahagamasekera Sheryl Young Tom Henderson Maria Hofmann Lance C. Jennings David R. Murdoch | 2013 | Journal of Infection2013，，2： | 1 |
| 7 | Conceptual model of recharge to southeastern Badain Jaran Desert groundwater and lakes from environmental tracers显示文摘 | John B Gates W Mike Edmunds W George Darling Jinzhu Ma Zhonghe Pang Adam A Young | 2008 | Applied Geochemistry2008，，12： | 1 |
| 8 | Extra-articular manifestations and complications of rheumatoid arthritis显示文摘 | Adam Young | 2007 | Best Practice & Research Clinical Rheumatology2007，，5： | 1 |
| 9 | Effectiveness of Prehospital Wireless Transmission of Electrocardiograms to a Cardiologist Via Hand-Held Device for Patients With Acute Myocardial Infarction (from the Timely Intervention in Myocardial Emergency, NorthEast Experience [TIME-NE])显示文摘 | George L. Adams Paul T. Campbell John M. Adams David G. Strauss Karen Wall Janet Patterson Kathy B. Shuping Charles Maynard Dwayne Young Craig Corey Alan Thompson Benjamin A. Lee Galen S. Wagner | 2006 | The American Journal of Cardiology2006，，9： | 1 |
| 10 | Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies显示文摘 | Ariella B. Hanker Adam D. Pfefferle Justin M. Balko María Gabriela Kuba Christian D. Young Violeta Sánchez Cammie R. Sutton Hailing Cheng Charles M. Perou Jean J. Zhao Rebecca S. Cook Carlos L. Arteaga | 2013 | Proceedings of the National Academy of Sciences2013，，35： | 1 |
| 11 | Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models显示文摘 | Taylor James G Cheuk Adam T Tsang Patricia S Chung Joon-Yong Song Young K Desai Krupa Yu Yanlin Chen Qing-Rong Shah Kushal Youngblood Victoria Fang Jun Kim Su Young Yeung Choh Helman Lee J Mendoza Arnulfo Ngo Vu Staudt Louis M Wei Jun S | 2009 | Journal of Clinical Investigation2009，，11： | 1 |
| 12 | Mutational analysis of 85 mucopelysaccharidosis type I families: frequency of known mutations, identification of 17 novel mutations and in vitro expression of missense mutations显示文摘 | Beesley CE Meaney CA Greenland G Adams V Vellodi A Young EP | 2001 | Hum Genet2001，109，5： | 1 |
| 13 | Performance Analysis of Digital Acoustic Communication in a Shallow Water Channel显示文摘 | Adam Z Young H Wu L X | 1995 | IEEE Journal of Oceanic Engineering1995，20，4： | 1 |
| 14 | Digital repeat photography for phenological research in forest ecosystems显示文摘 | Oliver Sonnentag Koen Hufkens Cory Teshera-Sterne Adam M. Young Mark Friedl Bobby H. Braswell Thomas Milliman John O’Keefe Andrew D. Richardson | 2011 | Agricultural and Forest Meteorology2011，，： | 1 |
| 15 | Osteopenia,neurological dysfunction,and the development of Charcot neuroarthropathy显示文摘 | Young M J Marshall A Adams J E | 1995 | Diabetes Care1995，18，： | 1 |
| 16 | A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma显示文摘 | Daniel H. Palmer Rachel S. Midgley Noweeda Mirza Elizabeth E. Torr Forhad Ahmed Jane C. Steele Neil M. Steven David J. Kerr Lawrence S. Young David H. Adams | 2008 | Hepatology2008，，1： | 1 |
| 17 | Pathways for arsenic from sediments to groundwater to streams: biogeochemical processes in the Inner Coastal Plain, New Jersey, USA显示文摘 | Julia L Barringer Adam Mumford Lily Y Young | 2010 | Water Research2010，44，： | 1 |
| 18 | Performance analysis of digital acoustic communication in a shallow water channel 显示文摘 | Adam Zielinski Young - Hoon Lixue Wu | 1995 | IEEE Journal of Oceanic Engineering1995，20，4： | 1 |
| 19 | Performance analysis of digital acoustic communication in a shallow water channel 显示文摘 | Zielinski Adam Yoon Young Hoon Wu Lixue | 1995 | IEEE Journal of Oceanic Engineering1995，20，4： | 1 |
| 20 | A portable data collection system for simultaneous cone penerometer force and volumetric soil water content measurements显示文摘 | Young G D Adams B A Topp G C | 2000 | Can J Soil Sci2000，80，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员