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| 1 | Mercury in aquatic fauna contamination:A systematic review on its dynamics and potential health risks显示文摘Mercury is an important pollutant,released into aquatic ecosystems both naturally and by anthropogenic action.This element is transferred to aquatic organisms in different ways,causing potential health risks.In addition,mercury can be accumulated by humans,especially through the consumption of contaminated food.This systematic review aims to present mercury pathways,the major routes through which this element reaches the aquatic environment and its transformations until becoming available to living animals,leading to bioaccumulation and biomagnification phenomena.The key biotic and abiotic factors affecting such processes,the impact of mercury on animal and human health and the issue of seafood consumption as a source of chronic mercury contamination are also addressed.A total of 101 articles were retrieved from a standardized search on three databases(PubMed,Emabse,and Web of Science),in addition to 28 other studies not found on these databases but considered fundamental to this review(totaling 129 articles).Both biotic and abiotic factors display fundamental importance in mediating mercurial dynamics,i.e.,muscle tropism,and salinity,respectively.Consequently,mercurial contamination in aquatic environments affects animal health,especially the risk of extinction species and also on human health,with methylmercury the main mercury species responsible for acute and chronic symptomatology. | Paloma de Almeida Rodrigues Rafaela Gomes Ferrari Luciano Neves dos Santos Carlos Adam Conte Junior | 2019 | Journal of Environmental Sciences2019，31，10： | 6 |
| 2 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 3 | Executive Summary: Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 5 |
| 4 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 5 | Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Robert J. Adams Jarett D. Berry Todd M. Brown Mercedes R. Carnethon Shifan Dai Giovanni de Simone Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Kurt J. Greenlund Susan M. Hailpern | 2011 | Circulation2011，，4： | 4 |
| 6 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 7 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 8 | Salmonella enterica Flagellin Is Recognized via FLS2 and Activates PAMP-Triggered Immunity in Arabidopsis thaliana显示文摘有沙门氏菌 enterica 的感染属于食物中毒和感染的水果的最突出的原因,蔬菜代表重要向量 forsalmonellosis。最近的证据显示植物认出 S。enterica 和加薪防卫回答。尽管如此,控制 S 的相互作用的分子的机制。有植物的 enterica 大部分仍然是不清楚的。这里,我们从 S 显示出那 flagellin。enterica 在 Arabidopsis thaliana 代表一个突出的联系病原体的分子的模式(PAMP ) ,它由受体 kinase FLS2 经由 flg22 领域的识别导致被触发 PAMP 的免疫(PTI ) 。Arabidopsis fls2 异种表演不过减少了没废除的 PTI 激活,显示植物也依靠另外的 S 的识别。enterica PAMP。有趣地, S。enterica 类型 III 分泌物系统(T3SS ) 异种 prgH 在 Arabidopsis 比野类型的细菌导致了更强壮的防卫基因表示,建议 T3SS 受动器涉及防卫抑制。而且,我们观察那 S。enterica 紧张在 flg22 epitope 显示出变化,它与减少的导致 PTI 活动导致蛋白质。总的来说, theseresults 表演那 S。enterica 在 Arabidopsis 激活 PTI 并且建议那,以便完成植物殖民, S。enterica 发展了策略避免或压制 PTI.Key 词: | Ana Victoria Garcia Amelie Charrier Adam Schikora Jean Bigeard Stephanie Pateyron Marie-Ludivine de Tauzia-Moreau Alexandre Evrard Axel Mithofer Marie Laure Martin-Magniette Isabelle Virlogeux-Payant Heribert Hirt | 2014 | Molecular Plant2014，7，4： | 3 |
| 9 | Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction显示文摘 | Ingo Eitel Volker Adams Patrick Dieterich Georg Fuernau Suzanne de Waha Steffen Desch Gerhard Schuler Holger Thiele | 2012 | American Heart Journal2012，，： | 2 |
| 10 | White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment显示文摘Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk factor.Methods We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension(SPRINT MIND)trial.The primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from enrolment.The primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH volumes.The secondary predictor was a binary WMH progression threshold(≥1.4 mL vs<1.4 mL).Results Among the 433 included patients,33(7.6%)developed dementia/MCI.There were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients with<1.4 mL WMH progression(p=0.002).In multivariable logistic regression,the Z score of WMH progression was associated with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRINT MIND,WMH progression over 48 months was associated with the development of probable dementia or MCI. | Adam de Havenon Kevin N Sheth Sharon D Yeatts Tanya N Turan Shyam Prabhakaran | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 11 | The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer显示文摘 | Craig P. Carden Adam Stewart Parames Thavasu Emma Kipps Lorna Pope Mateus Crespo Susana Miranda Gerhardt Attard Michelle D. Garrett Paul A. Clarke Paul Workman Johann S. de Bono Martin Gore Stan B Kaye Udai Banerji | 2012 | Molecular Cancer Therapeutics2012，，7： | 2 |
| 12 | Repeat hepatectomy for recurrent colorectal metastases显示文摘 | D. A. Wicherts R. J. de Haas C. Salloum P. Andreani G. Pascal D. Sotirov R. Adam D. Castaing D. Azoulay | 2013 | Br J Surg2013，，6： | 2 |
| 13 | Early mortality and safety after transcatheter aortic valve replacement using the SAPIEN 3 in nonagenarians显示文摘BackgroundTranscatheter 大动脉的阀门代替(TAVR ) 与严重大动脉的狭窄为许多老病人被执行了(作为) 。智慧 3 是最近的汽球可扩充的修复术之一。试图用在 97 个连续病人全部的 nonagenarians.MethodsA 的 SAPIEN 3 在 TAVR 以后调查早临床的结果的这研究经历了 TAVR 为象在 2015 年 12 月和 2016 年 12 月之间严重。这些,用 SAPIEN 3 经历了 TAVR 的 85 个连续病人被包括。根据年龄,病人们被分类直到 90 年组织的年龄(17 个病人) 或年龄 < 90 年组(68 个病人) 。包括所有原因死亡和在 30 天的早安全的合成端点的临床的结果是在年龄 90 年组的胸的外科医生分数的 evaluated.ResultsThe 社会比年龄高< 90 年组( 12.3 慳敧愠??敲楧湯污猠慣敬愠摮?湩瀠牡楴畣慬?映牯搠晩敦敲瑮氠湡?獵?祴数?渠敥?潭敲爠獥慥'??畯?景琠敨洠獯?楷敤祬搠獩牴扩瑵摥氠湡?獵?祴数?敷敲猠汥'陶?潴愠慮祬敺?湩汣摵湩?湩牴摯'讚硴城嬊N蹡P慲獳慬摮?獡眠汥?獡椠瑮潲畤散?湡?慮畴慲?桳畲汢湡?匠楯?慰瑲捩敬猠穩?猠楯?牯慧楮?慭瑴牥愠摮漠桴? | Eiji Ichimoto Adam Arnofsky Michael Wilderman Richard Goldweit Joseph De Gregorio | 2018 | Journal of Geriatric Cardiology2018，15，6： | 2 |
| 14 | Formation of pyrazines from ascorbic acid and amino acids under dry-roasting conditions显示文摘 | An Adams Norbert De Kimpe | 2009 | Food Chemistry2009，，4： | 2 |
| 15 | Liver transplantation for HBV-related cirrhosis in Europe: An ELTR study on evolution and outcomes显示文摘 | Patrizia Burra Giacomo Germani Renè Adam Vincent Karam Alfredo Marzano Pietro Lampertico Mauro Salizzoni Franco Filipponi Jurgen L. Klempnauer Denis Castaing Murat Kilic Luciano De Carlis Peter Neuhaus Sezai Yilmaz Andreas Paul Antonio D. Pinna Andrew K. | 2012 | Journal of Hepatology2012，，： | 2 |
| 16 | Decomposition of surface EMG signals 显示文摘 | DE LUCA C J ADAM A WOTIZ R | 2006 | Journal of Neurophysiology2006，96，3： | 1 |
| 17 | Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab 显示文摘 | Adams CW Allison DE Flagella K | 2006 | Cancer Immunol Immunother2006，55，6： | 1 |
| 18 | Coproduction of novel 16S rRNA methylase RmtD and metallo beta Lactamase SPM 1 in a panresistant pseudomonas aeruginosa isolate from Brazil显示文摘 | Doi Y De Oliveira Garcia D Adams J | 2007 | Antimierobial Agents and Chemotherapy2007，51，3： | 1 |
| 19 | Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate显示文摘 | de Oliveira A Adams S D Lee L H | | 0，，： | 1 |
| 20 | Erythromycin in neonatal postoperative intestinal dysmotility 显示文摘 | Simkiss DE Adams IP Myrdal U et ol | 1994 | Arch Dis Child1994，71，2： | 1 |
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