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| 1 | Bioreductive prodrugs as cancer therapeutics:targeting tumor hypoxia显示文摘Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with disease progression as well as resistance to radiotherapy and certain chemotherapeutic drugs. Hypoxic regions in tumors, therefore, represent attractive targets for cancer therapy. To date, five distinct classes of bioreactive prodrugs have been developed to target hypoxic cells in solid tumors. These hypoxia-activated prodrugs, including nitro compounds, N-oxides, quinones, and metal complexes, generally share a common mechanism of activation whereby they are reduced by intracellular oxidoreductases in an oxygensensitive manner to form cytotoxins. Several examples including PR-104, TH-302, and EO9 are currently undergoing phase II and phase III clinical evaluation. In this review, we discuss the nature of tumor hypoxia as a therapeutic target, focusing on the development of bioreductive prodrugs. We also describe the current knowledge of how each prodrug class is activated and detail the clinical progress of leading examples. | Christopher P.Guise Alexandra M.Mowday Amir Ashoorzadeh Ran Yuan Wan-Hua Lin Dong-Hai Wu Jeff B.Smaill Adam V.Patterson Ke Ding | 2014 | Chinese Journal of Cancer2014，33，2： | 9 |
| 2 | Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images via scalable deep learning显示文摘BACKGROUND Hepatic steatosis is a major cause of chronic liver disease.Two-dimensional(2D)ultrasound is the most widely used non-invasive tool for screening and monitoring,but associated diagnoses are highly subjective.AIM To develop a scalable deep learning(DL)algorithm for quantitative scoring of liver steatosis from 2D ultrasound images.METHODS Using multi-view ultrasound data from 3310 patients,19513 studies,and 228075 images from a retrospective cohort of patients received elastography,we trained a DL algorithm to diagnose steatosis stages(healthy,mild,moderate,or severe)from clinical ultrasound diagnoses.Performance was validated on two multiscanner unblinded and blinded(initially to DL developer)histology-proven cohorts(147 and 112 patients)with histopathology fatty cell percentage diagnoses and a subset with FibroScan diagnoses.We also quantified reliability across scanners and viewpoints.Results were evaluated using Bland-Altman and receiver operating characteristic(ROC)analysis.RESULTS The DL algorithm demonstrated repeatable measurements with a moderate number of images(three for each viewpoint)and high agreement across three premium ultrasound scanners.High diagnostic performance was observed across all viewpoints:Areas under the curve of the ROC to classify mild,moderate,and severe steatosis grades were 0.85,0.91,and 0.93,respectively.The DL algorithm outperformed or performed at least comparably to FibroScan control attenuation parameter(CAP)with statistically significant improvements for all levels on the unblinded histology-proven cohort and for“=severe”steatosis on the blinded histology-proven cohort.CONCLUSION The DL algorithm provides a reliable quantitative steatosis assessment across view and scanners on two multi-scanner cohorts.Diagnostic performance was high with comparable or better performance than the CAP. | Bowen Li Dar-In Tai Ke Yan Yi-Cheng Chen Cheng-Jen Chen Shiu-Feng Huang Tse-Hwa Hsu Wan-Ting Yu Jing Xiao Lu Le Adam P Harrison | 2022 | World Journal of Gastroenterology2022，28，22： | 2 |
| 3 | Effect of postop- erative skin-surface warming on oxygen consumption and the shivering threshold 显示文摘 | Alfonsi P Nourredine KE Adam F | 2003 | Anaesthesia2003，58，12： | 1 |
| 4 | Effect of computer order entry on prevention of serious medication errors in hospitalized Chil - dren 显示文摘 | Walsh KE Landrigan CP Adams WG | 2008 | Pediatrics2008，21，3： | 1 |
| 5 | Effect of postop- erative skin-surface warming on oxygen consumption and the shivering threshold 显示文摘 | Alfonsi P Nourredine KE Adam F | 2003 | Anaesthesia2003，58，12： | 1 |
| 6 | Evaluation of the ID gel test for antibody screening and identification显示文摘 | Bromilow IM Adams KE Hope J | 1991 | Tranfusion Med1991，1，： | 1 |
| 7 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | The Lancet2012，，9819： | 1 |
| 8 | Evaluation of the ID-gel test for antibody screening and identification显示文摘 | Bromilow IM Adams KE Hpe J | 1991 | Transfus Med1991，1，3： | 1 |
| 9 | Quantitative assessment of the 103-hexagon multifocal electroretinogram in detection of hydroxychloroquine retinal toxicity显示文摘 | Adam MK Covert DJ Stepien KE | 2012 | Br J Ophthalmol2012，96，5： | 1 |
| 10 | Evaluation of the ID gel test forantibody screening and identify-ication显示文摘 | Bmmilow IM Adams KE Hope J | 1991 | Tranfusion Med1991，1，2： | 1 |
| 11 | Medication errors re- lated to computerized order entry for children 显示文摘 | Walsh KE Adams WG Bauchner H | 2006 | Pediatrics2006，118，5： | 1 |
| 12 | Deactivation of accelerated engine-aged and field-aged Fe–zeolite SCR catalysts显示文摘 | TODD J Toops KE Nguyen ADAM L Foster | 2010 | Catalysis Today2010，151，3： | 1 |
| 13 | Comparison of visibleand near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer显示文摘 | Adams K E Ke S Kwon S | 2007 | Journal of biomedical op- tics2007，12，2： | 1 |
| 14 | Effect of postoperative skinsurface Wanning on oxygen consumption and the shiveringthreshold 显示文摘 | Alfonsi P Nourredine KE Adam F | 2003 | Anaesthesia2003，58，12： | 1 |
| 15 | A rare case of petrified ear显示文摘 | Buikema KE Adams EG | 2012 | Case Rep Dermatol Med2012，2012，41： | 1 |
| 16 | Evaluation of the ID-gel test for ant ibody screening and identification显示文摘 | Bromilow IM Adams KE Hope J | | 0，，03： | 1 |
| 17 | Role of dexmedetomi- dine in adults in the intensive care unit: an update 显示文摘 | Reardon DP Anger KE Adams CD | 2013 | Am J Health Syst Pharm2013，70，9： | 1 |
| 18 | Evaluation of the ID gel test for antibody screening and identification显示文摘 | Bromilow IM Adams KE Hope J | 1991 | Tranfusion Med1991，1，： | 1 |
| 19 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | 2012 (9819)2012，，9819： | 1 |
| 20 | Chromophereenhanced in vivo tumor cell destruction using an 808nm diomed laser显示文摘 | Adams RL Bartels KE | 1995 | Cancer Lett1995，94，： | 1 |
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