|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | The use of PCR for the identification and characterization bacterioc in genes from bacterial strains isolated from rn- men or caecal contents of cattle and sheep显示文摘 | Adrian L Cookson Samantha J Noel Kelly W J | 2004 | FEMS Mi- crobiology Ecology2004，48，2： | 1 |
| 3 | The innate immune response to bacterial agellin is mediated by Toll-like receptor 5显示文摘 | Fumitaka H Kelly S D Adrian O | 2001 | Nature2001，410，6832： | 1 |
| 4 | Service-based Health Human Resources Planning for Older Adults显示文摘 | Gail Tomblin Murphy Adrian MacKenzie Janet Rigby Kenneth Rockwood Amy Gough Gogi Greeley Frederick Montpetit Donna Dill Robert Alder Kelly Lackie | 2013 | Journal of the American Medical Directors Association2013，，： | 1 |
| 5 | SAFE USE OF HEPATIC ALLOGRAFTS FROM DONORS OLDER THAN 70 YEARS1显示文摘 | Sukru Emre Myron E. Schwartz Gulum Altaca Paul Sethi M. Isabel Fiel Stephen R. Guy Dympna M. Kelly Anthony Sebastian Adrian Fisher Denise Eickmeyer Patricia A. Sheiner Charles M. Miller | 1996 | Transplantation1996，，1： | 1 |
| 6 | Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor显示文摘 | Brent J. Tierney Georgia A. McCann Shan Naidu Kellie S. Rath Uksha Saini Ross Wanner Periannan Kuppusamy Adrian Suarez Paul J. Goodfellow David E. Cohn Karuppaiyah Selvendiran | 2014 | Gynecologic Oncology2014，，1： | 1 |
| 7 | Randomized Controlled Trial of Intradialytic Resistance Training to Target Muscle Wasting in ESRD: The Progressive Exercise for Anabolism in Kidney Disease (PEAK) Study显示文摘 | Bobby Cheema Haifa Abas Benjamin Smith Anthony O’Sullivan Maria Chan Aditi Patwardhan John Kelly Adrian Gillin Glen Pang Brad Lloyd Maria Fiatarone Singh | 2007 | American Journal of Kidney Diseases2007，，4： | 1 |
| 8 | Perspectives on Future Power System Control Centers for Energy Transition显示文摘Today's power systems are seeing a paradigm shift under the energy transition,sparkled by the electrification of demand,digitalisation of systems,and an increasing share of decarbonated power generation.Most of these changes have a direct impact on their control centers,forcing them to handle weather-based energy resources,new interconnections with neighbouring transmission networks,more markets,active distribution networks,micro-grids,and greater amounts of available data.Unfortunately,these changes have translated during the past decade to small,incremental changes,mostly centered on hardware,software,and human factors.We assert that more transformative changes are needed,especially regarding human-centered design approaches,to enable control room operators to manage the future power system.This paper discusses the evolution of operators towards continuous operation planners,monitoring complex time horizons thanks to adequate real-time automation.Reviewing upcoming challenges as well as emerging technologies for power systems,we present our vision of a new evolutionary architecture for control centers,both at backend and frontend levels.We propose a unified hypervision scheme based on structured decision-making concepts,providing operators with proactive,collaborative,and effective decision support. | Antoine Marot Adrian Kelly Matija Naglic Vincent Barbesant Jochen Cremer Alexandru Stefanov Jan Viebahn | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员