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| 1 | The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children显示文摘Objective:To determin the extent to which parvovirus B19(B19V)and co-infection of B19V and malaria contribute to risk of anaemia in children.Methods:B19V DNA and malaria parasites were screened for 234 children at the PMI,Children's Hospital in Accra.The role of B19V and coinfection with B19V and malaria in anaemia was evaluated by analysing full blood cell counts,malaria and B19V DNA results from these children.Results:The prevalence of B19V,malaria and co-infection with B19V and malaria was 4.7%,41.9%and 2.6%,respectively.Malaria posed a greater risk in the development of mild anaemia compared to severe anaemia(OR=5.28 vrs3.15)whereas B19V posed a higher risk in the development of severe anaemia compared to mild anaemia(OR=4.07 vrs 1.00)from a non-anaemic child.Persons with co-infection with B19V and malaria had 2.23 times the risk(95%CI=0.40-12.54)of developing severe anaemia should they already have a mild anaemia.The degree of anaemia was about three times affected by coinfection(Pillai's trace=0.551,P=0.001)as was affected by malaria alone(Pillai's trace=0.185,P=0.001).B19V alone did not significantly affect the development of anaemia in a non-anaemic child.Microcytic anaemia was associated with B19V and co-infection with B19V and malaria more than normocytic normochromic anaemia.Conclusions:B19V was associated with malaria in cases of severe anaemia.The association posed a significant risk for exacerbation of anaemia in mild anaemic children.B19V and co-infection with B19V and malaria may be associated with microcytic anaemia rather than normocytic normochromic anaemia as seen in cases of B19V infection among persons with red cell abnormalities. | Kwabena Obeng Duedu Kwamena William Coleman Sagoe Patrick Ferdinand Ayeh-Kumi Raymond Bedu Affrim Theophilus Adiku | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 3 |
| 2 | A pharmacokinetic profile of desloratadine in healthy adults,including elderly 显示文摘 | AFFRIME M GUPTA S BANFIELD C | 2002 | Clin Pharmacokinet2002，41，1： | 1 |
| 3 | Desloratadine demonstrates dose proportionality in healthy adults after single doses 显示文摘 | GUPTA S BANFIELD C AFFRIME M | 2002 | Clin Pharma-cokinet2002，41，1： | 1 |
| 4 | Oral bioavailability of desloratadine is unaffected by food 显示文摘 | GUPTA S BANFIELD C AFFRIME M | 2002 | Clin Pharmacokinet2002，41，1： | 1 |
| 5 | Clinical, hematologic, and immunologic effects of interleukin-10 in humans显示文摘 | Amy C. Fuchs Eric V. Granowitz Leland Shapiro Edouard Vannier Gerhard Lonnemann Jonathan B. Angel Jeffrey S. Kennedy Arthur R. Rabson Elaine Radwanski Melton B. Affrime David L. Cutler Paul C. Grint Charles A. Dinarello | 1996 | Journal of Clinical Immunology1996，，5： | 1 |
| 6 | Attenuation of proinflammatory response by recombinant human IL - 10 in human endotox- emia:effeet of timing of recombinant human IL - 10 administration 显示文摘 | Pajkrt D Camoglio L Tiel -van Buul M C de Bruin K Cutler D L Affrime M B Rikken G van der Poll T ten Care J W van Deventer S J | 1997 | Journal of immunolo- gy1997，158，8： | 1 |
| 7 | Desloratadine and Ketoconazole; Pharmacokinetics and electrocardiogrphic pharmacodynamic effects显示文摘 | Affrime MB Banfield C Clue P | 2000 | J Allergy Clin Immunol2000，104，： | 1 |
| 8 | Desloratadine and ketoconazole: Pharmacokinetics and electrocardiographic pharmacodynamic effects显示文摘 | Affrime M B | 2000 | J Allergy Clin lmmunol2000，105，12： | 1 |
| 9 | Desioratadine,and erythromycin:pharmacokinetics and electrocardiogrphic pharmacodynamymic effects显示文摘 | Glue P Banfield C Affrime MB | 2000 | J Allergy Clin Immunol2000，104，： | 1 |
| 10 | Comparative bioavailability of ceftibuten in capsule and suspension forms显示文摘 | Lin CC Affrime M Radwanski E | 1996 | Clin Ther1996，18，： | 1 |
| 11 | Desloratadine de- monstrates dose proportionality in healthy adults after single doses 显示文摘 | Gupta S Banfield C Affrime M | 2002 | Clin Pharmacokinet2002，41，1： | 1 |
| 12 | Dose-proport-ionality, linearity, and pharmacokinetics of desloratadi-ne in healthy adults显示文摘 | Padhi D Affrime MB | 2000 | J Allergy Clin Immunol2000，105，12： | 1 |
| 13 | Desloratadineand erythromycin: Pharmacokinetics and electrocardio-graphic pharmacodynamic effects显示文摘 | Banfield C Affrime MB | 2000 | J Allergy Clin Im-munol2000，105，12： | 1 |
| 14 | Desloratadineand ketoconazole:Pharmacokinetics and electrocardiog-raphic pharmacodynamic effects显示文摘 | Banfield C Glue P | 2000 | J Allergy Clin Im-munol2000，105，12： | 1 |
| 15 | Three month evaluation of electrocardiographic effects of loratidine in humans显示文摘 | Lorber R Danzig M | 1993 | Allerge1993，48，： | 1 |
| 16 | Oral bioavailability of desloratadine is unaffected by food显示文摘 | Gupta S Banfield C Affrime M | 2002 | Clin Pharmacokinet2002，411，： | 1 |
| 17 | Desloratadine and Ketoconazoie;pharmacokineties and electrocardiographic pharmacodynamic diffects显示文摘 | Affrime MB Banfield C Glue P | 2000 | J Allergy Clin Immunol2000，104，： | 1 |
| 18 | Desloratadine and erythromythin: pharmacokinetics and electrocardiographic pharmacodynamymie effcts 显示文摘 | Glue P Bfield C Affrime MB | 2000 | J Allergy Clin lmmnunol2000，104，： | 1 |
| 19 | Desloratadine and eryth-romycin: pharmacokinetics and electrocardiographic pharmacody-namic effects显示文摘 | Glue P Banfield C Affrime MB | 2000 | J Allergy Clin Immunol2000，105，1： | 1 |
| 20 | Desloratadine and ketoconazole: pharmacokinetics and electrocardiographic pharmacody-namic effects显示文摘 | Affrime MB Banfield C Glure P | 2000 | J Allergy Clin Immunol2000，105，1： | 1 |
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