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| 1 | N-IN- - ( S ) -alanyl t- (S) -phe- nylglycine tert-butyl ester(DAPT) : an inhibitor of gam- ma-secretase, revealing fine electronic and hydrogen- bonding features显示文摘 | Czerwinski A Valenzuela F Afonine P | 2010 | Acta Crystallogr C2010，66，12： | 1 |
| 2 | Evaluating the amino acid CF3-bicyclopentylglycine as a new label for solid state 19F NMR structure analysis of membrane-bound peptides 显示文摘 | Afonin S Mikhailiuk P K Komarov I V | 2007 | J Pept Sci2007，13，9： | 1 |
| 3 | Solid-state 19F NMR of peptides in native membranes显示文摘 | Koch K Afonin S Ieronimo M | 2012 | Top Curr Chem2012，，： | 1 |
| 4 | Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS显示文摘 | Brian F. Pachkowski Keizo Tano Valeriy Afonin Rhoderick H. Elder Shunichi Takeda Masami Watanabe James A. Swenberg Jun Nakamura | 2009 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2009，，1： | 1 |
| 5 | Fossil wood of Sequoioxylon burejense sp. nov. (Taxodiaceae) from the Upper Cretaceous of the Zeya-Bureya Basin (Russian Far East)显示文摘 | N. I. Blokhina M. A. Afonin T. M. Kodrul | 2010 | Paleontological Journal2010，，10： | 1 |
| 6 | Effect of Structural Anisotropy on Contact Properties in a Silver - Graphite Composite显示文摘 | Mikhail P. Afonin Andrei V. Boiko | 2005 | Powder Metallurgy and Metal Ceramics (-)2005，，1： | 1 |
| 7 | Oscillatory Extraction System with a Liquid Membrane for Separating REEs显示文摘 | A. A. Kopyrin A. A. Baulin M. A. Afonin | 2005 | Radiochemistry2005，，4： | 1 |
| 8 | PHENIX:a comprehensive Python-based system for macromolecular structure solution显示文摘 | Adams PD Afonine PV Bunkoczi G | 2010 | Acta Crystallogr D Biol Crystallogr2010，66，2： | 1 |
| 9 | Thermal effects and evolution of the defect concentration based on shear modulus relaxation data in a Zr-based metallic glass显示文摘A relationship between thermal effects and relaxation of the high-frequency shear modulus upon heat treatment of bulk Zr48(Cu5/6Ag1/6)44Al8 metallic glass is found.This relationship is attributed to the relaxation of a interstitial-type defect system frozen-in from the melt upon glass production.Calorimetric data show that thermal effects occurring on heating include heat release below the glass transition temperature,heat absorption above it and heat release caused by crystallization.The equation derived within the Interstitialcy theory can be used to calculate the shear modulus relaxation using the calorimetric data.The obtained results are used to trace the defect concentration as functions of temperature and thermal prehistory. | 郝奇 乔吉超 E V Goncharova G V Afonin 刘敏娜 程怡婷 V A Khonik | 2020 | Chinese Physics B2020，29，8： | 1 |
| 10 | PHENIX:a comprehensive Python-based system for macromolecular structure solution显示文摘 | Adams PD Afonine PV Bunkoczi G | 2010 | Acta Cryst D2010，66，： | 1 |
| 11 | In vitro assembly of cubic RNA-based scaffolds designed in silico显示文摘 | Afonin K A Binderwald E Yaghoubian A J | | 0，，： | 1 |
| 12 | A convenient route to triflu- oromethyl - substituted cyclopropane derivatives 显示文摘 | Mykhailiuk P K Afonin S | 2008 | Syn- thesis2008，11，： | 1 |
| 13 | Optimized protocol for synthesis of cyclic gramicidin S:starting amino acid is key to high yield显示文摘 | Wadhwani P Afonin S Ieronimo M | 2006 | J Org Chem2006，71，1： | 1 |
| 14 | PHENIX: a comprehensive Python-based system for macromolecular structure solution 显示文摘 | Adams PD Afonine PV Bunkoczi G | 2010 | Acta Crystallogr D Biol Crystallogr2010，66，21： | 1 |
| 15 | The ability of Aneurinibacillus migulanus (Bacillus brexds) to produce the antibiotic gramicidin S is correlated with phenotype varia-tion显示文摘 | Berditsch M Afonin S Ulrich A S | 2007 | Appl Environ Microbiol2007，73，20： | 1 |
| 16 | N-{ N-J2-( 3,5 Dif- luorophenyl ) acetyl ]-( S )-alanyl }-( S )-phenylglycine tert-butyl ester (DAPT):an inhibitor of '-secretase, revealing fine elec- tronic and hydrogen-bonding features显示文摘 | Czerwinski A Valenzuela F Afonine P | 2010 | Acta Crystallogr C2010，66，12： | 1 |
| 17 | PHENIX : acomprehensive Python-based system for macromolecular structuresolution显示文摘 | Adams P D Afonine P V 6unk6czi G | 2010 | Acta Crystallogr D Biol Crystallogr2010，66，2： | 1 |
| 18 | In Silico,In vitro,and in vivo studies indicate the potential Use of Bola amphiphiles for therapeutic siRNAs delivery显示文摘 | KIM K AFONIN K A VIARD M | 2013 | Molecular Therapy-Nucleic Acids2013，2，80： | 1 |
| 19 | Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project显示文摘AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term spaceflights.METHODS:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 Project.In particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid meals.In addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal inflammation.Because no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the experiment.RESULTS:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external assistance.No evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy subjects.In contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same subject.This variability suggested that the H 2-breath test was strongly affected by external factors,which may have been related to the diet of the crewmembers or to environmental conditions(e.g.,the accumulation of hydrogen in the simulator microenvironment).At least in closed microenvironments such as the MARS-500 simulator,13 C-breath tests should therefore be preferred to H 2-breath tests.Finally,the fecal calprotectin test showed significant alterations during the mission simulation:all of the crewmembers were negative for the test at the beginning of the simulation but showed various degrees of positivity in at least one of the subsequent tests,thus indicating the onset of an intestinal inflammation.CONCLUSION:Breath tests,especially those 13 Cbased,proved suitable for monitoring gastrointestinal motility in the 520-d isolation experiment withinMARS-500 project and can be applied in long-term spaceflights. | Aldo Roda Mara Mirasoli Massimo Guardigli Patrizia Simoni Davide Festi Boris Afonin Galina Vasilyeva | 2013 | World Journal of Gastroenterology2013，19，14： | 1 |
| 20 | PHENIX: a comprehensive Python-based system for macromolecular structure solution显示文摘 | Adams PD Afonine PV Bunkoczi c | 2010 | Acta Crystallogr D Bioi Crystallogr2010，66，2： | 1 |
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