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| 1 | Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways显示文摘Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)tract.The elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI inflammation.Various natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD drugs.Thereby,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO pathway.Electronic databases including Google Scholar and PubMed were searched from 1980 to May 2018.We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling pathways.Prebiotics and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways. | Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi Amir Hossein Abdolghaffari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology显示文摘 | Sibylle A. Kozek-Langenecker Arash Afshari Pierre Albaladejo Cesar Aldecoa Alvarez Santullano Edoardo De Robertis Daniela C. Filipescu Dietmar Fries Klaus G?rlinger Thorsten Haas Georgina Imberger Matthias Jacob Marcus Lancé Juan Llau Sue Mallett Jens Mei | 2013 | European Journal of Anaesthesiology2013，，6： | 3 |
| 3 | Experimental Analysis and Evaluation of Thermostat Effects on Engine Cooling System显示文摘Thermostat as a part of engine cooling system has a significant role in the shortening warm-up time and regulating the engine in proper temperature to approach optimal performance.Whereas,there is not adequate research on this part of the cooling system and its responsibility.Considering this gap and also being used in large scale,this study is intended to evaluate performance and reflex of the wax type thermostat in different engine working conditions.In this regard,performance of engine cooling system was investigated in various engine speeds and loads to reveal positive and negative influences of thermostat on engine cooling efficiency and engine performance.According to observed results,warm-up period and fuel consumption decrease by using a thermostat.On the other hand,however,the temperature oscillation of coolant fluid passing through engine increases sharply,which causes a disruption in the regulating engine temperature and also a possibility of the fluid boiling rises in some regions of the engine that increases the risk of damage in the engine parts.Engine temperature,fuel consumption,warm-up duration and emissions were provided and compared in two operation modes,with and without thermostat. | GHASEMI ZAVARAGH Hadi KALELI Alirlza SOLMUS Ismail AFSHARI Faraz | 2021 | Journal of Thermal Science2021，30，2： | 3 |
| 4 | Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure显示文摘 | Steenbergen C Afshari CA Petranka JG | 2003 | Am J Physiol Heart Circ Physiol2003，284，1： | 2 |
| 5 | 采用Fe_(2)O_(3)/水纳米流体强化翅片管壳换热器的传热显示文摘为了优化效率和减少能量损失,需要对传热机理及热性能进行全面研究。在基液中加入不同的纳米颗粒可提高热交换器的热性能。设计了一种翅片管壳式换热器,以体积浓度分别为1%、1.5%、2%的Fe_(2)O_(3)/水纳米流体作为换热流体,研究不同体积浓度的纳米流体对传热的影响,并将所得结果与纯水作为换热流体结果进行比较。采用ANSYS Fluent软件对传热过程进行数值模拟。数值模拟结果表明:纳米流体可成功应用于换热器中,提高Fe_(2)O_(3)纳米颗粒的体积分数可以获得更大的热能,而不会产生明显的压降。此外,当纳米流体中Fe_(2)O_(3)的体积分数为2%时,其传热速率提高率最高,为19.1%。 | AFSHARI Faraz SÖZEN Adnan KHANLARI Ataollah TUNCER Azim Doğuş | 2021 | Journal of Central South University2021，28，11： | 2 |
| 6 | A numerical study on heat transfer enhancement and design of a heat exchanger with porous media in continuous hydrothermal flow synthesis system显示文摘The aim of this study is to use a new configuration of porous media in a heat exchanger in continuous hydrothermal flow synthesis(CHFS)system to enhance the heat transfer and minimize the required length of the heat exchanger.For this purpose,numerous numerical simulations are performed to investigate performance of the system with porous media.First,the numerical simulation for the heat exchanger in CHFS system is validated by experimental data.Then,porous media is added to the system and six different thicknesses for the porous media are examined to obtain the optimum thickness,based on the minimum required length of the heat exchanger.Finally,by changing the flow rate and inlet temperature of the product as well as the cooling water flow rate,the minimum required length of the heat exchanger with porous media for various inlet conditions is assessed.The investigations indicate that using porous media with the proper thickness in the heat exchanger increases the cooling rate of the product by almost 40% and reduces the required length of the heat exchanger by approximately 35%.The results also illustrate that the most proper thickness of the porous media is approximately equal to 90% of the product tube's thickness.Results of this study lead to design a porous heat exchanger in CHFS system for various inlet conditions. | Pedram Karimi Pour-Fard Ebrahim Afshari Masoud Ziaei-Rad Shahed Taghian-Dehaghani | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 2 |
| 7 | Sludge ash as fine aggregate for concrete mix 显示文摘 | Khanbilvardi R Afshari S | 1995 | Journal of environmental engineering1995，121，9： | 1 |
| 8 | Yr32 for resistance to stripe (yellow) rust present in the wheat cultivar Carstens V显示文摘 | L. Eriksen F. Afshari M. J. Christiansen R. A. McIntosh A. Jahoor C. R. Wellings | 2004 | Theoretical and Applied Genetics2004，，3： | 1 |
| 9 | Antithrombin Ⅲ in critically ill patients: systematic review with meta- analysis and trial sequential analysis 显示文摘 | Afshari A Wetterslev J Brok J | 2007 | BMJ2007，335，7632： | 1 |
| 10 | Experimental investi- gation of twisted tape inserts performance on condensation heat transfer enhancement and pressure drop 显示文摘 | Hejazi V Akhavan-Behabadi M A Afshari A | 2010 | International Commu- nications in Heat and Mass Transfer2010，37，： | 1 |
| 11 | Cloning and characterization of the promoter region of telomerase reverse transcriptase gene显示文摘 | Horikawa I Cable P L Afshari C | 1999 | Cancer Res1999，59，4： | 1 |
| 12 | Is periodontal disease related to preeclampsia?显示文摘 | Yaghini J Mostajeran F Afshari E | 2012 | Dent Res J (Isfahan)2012，9，6： | 1 |
| 13 | Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice显示文摘 | Ghosh S Khazaei M Moien -Afshari F | 2009 | Am J Physiol Renal Physiol2009，38，296： | 1 |
| 14 | Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy,age-related maculopathy,and bull' s-eye maculopathy显示文摘 | Seddon JM Afshari MA Sharma S | 2001 | Ophthalmology2001，108，： | 1 |
| 15 | Awake fiberoptic or awake video laryngoscopic tracheal intubation in patients with anticipated difficult airway management:a randomized clinical trial显示文摘 | Rosenstock CV Thgersen B Afshari A | 2012 | Anesthesiology2012，116，6： | 1 |
| 16 | Antithrombin Ⅲ in critically ill patients:systematic review with metaanalysis and trial sequential analysis显示文摘 | Afshari A Wetterslev J Brok J | 2007 | BMJ2007，335，7632： | 1 |
| 17 | Porous nylon-6 fibersvia a novel salt-induced electrospinng method显示文摘 | Gupta A Saquing C Afshari M | 2009 | Macromole-cules2009，42，3： | 1 |
| 18 | Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene显示文摘 | Horikawa I Cable PL Afshari C | 1999 | Cancer Res1999，59，： | 1 |
| 19 | BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor 显示文摘 | Zheng L Annab LA Afshari CA | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 20 | Pearls for successful cataract surgery with endothelial keratoplasty显示文摘 | Chang ST Yamagata AS Afshari NA | 2014 | Curr Opiu Ophthalmol2014，25，4： | 1 |
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