|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells显示文摘Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopausal osteoporosis, induces osteogenesis by activating the estrogen receptor signaling pathway and upregulating the expression of osteogenic genes, such as bone morphogenetic proteins(BMPs). The epigenetic regulation of estrogen-mediated osteogenesis,however, is still unclear. In this report, we found that estrogen significantly induced the expression of lysine-specific demethylase 6B(KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of DMSCs.Mechanistically, upon estrogen stimulation, estrogen receptor-α(ERα) was recruited to the KDM6B promoter, directly enhancing KDM6B expression. Subsequently, KDM6B was recruited to the BMP2 and HOXC6 promoters, resulting in the removal of H3K27me3 marks and activating the transcription of BMP2 and HOXC6, the master genes of osteogenic differentiation. Furthermore, we found that estrogen enhanced DMSC osteogenesis during calvarial bone regeneration and that estrogen’s pro-osteogenic effect was dependent on KDM6B in vivo. Taken together, our results demonstrate the vital role of the ERα/KDM6B regulatory axis in the epigenetic regulation of the estrogen-dependent osteogenic response. | Zhenqing Liu Hye-Lim Lee Jin Sook Suh Peng Deng Chang-Ryul Lee Olga Bezouglaia Mojan Mirnia Vivian Chen Michael Zhou Zhong-Kai Cui Reuben HKim Min Lee Tara Aghaloo Christine Hong Cun-Yu Wang | 2022 | Bone Research2022，10，1： | 2 |
| 2 | Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat显示文摘 | Aghaloo TL Kang B Sung EC | 2011 | J Bone Miner Res2011，26，8： | 1 |
| 3 | Nell-1-induced bone regeneration in calvarial defects 显示文摘 | Aghaloo T Cowan C M Chou Y F | 2006 | Am J Pathol2006，169，3： | 1 |
| 4 | Investigation of platelet rich plasma in rabbit cranial defects:A pilot study显示文摘 | Moy PK Freymiller EG | 2002 | J Oral Maxillofac Surg2002，60，10： | 1 |
| 5 | Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement? 显示文摘 | Aghaloo TL Moy PK | 2007 | Int J Oral Maxillofac Implants2007，22，1： | 1 |
| 6 | Investigation of platelet-rich plasmain rabbit cranial defects:A pilot study显示文摘 | Aghaloo TL Moy PK Freymil er EG | | 0，，10： | 1 |
| 7 | Nell-1-induced bone regeneration in calvarial defects显示文摘 | Aghaloo T Cowan C M Chou Y F | 2006 | AMJ Pathol2006，169，3： | 1 |
| 8 | A study of the role of nell-1 gene modified goat bone marrow stromal ceils in promoting new bone formation显示文摘 | Aghaloo T Jiang X Soo C | 2007 | Mol Ther2007，15，10： | 1 |
| 9 | The effect of NELLI and bone morphogenetic protein-2 on cal?varial bone regeneration显示文摘 | Aghaloo T Cowan CM Zhang X | 2010 | J Oral Maxillofac Surg2010，68，2： | 1 |
| 10 | Nell-1-induced bone regeneration in calvarial defects显示文摘 | Aghaloo T Cowan CM Chou YF | 2006 | Am J Pathol2006，169，3： | 1 |
| 11 | Which hard tissue augmentation techniques are the most successful in furnishing bony sup- port for implant placement显示文摘 | Aghaloo TL Moy PK | 2007 | Oral Maxillofac Implants2007，22，1： | 1 |
| 12 | Effects of periodontal treatment phase I on birth term and birth weight显示文摘 | Sadatmansouri S Sedighpoor N Aghaloo M | 2006 | Indian Soc Pedod Prey Dent2006，24，1： | 1 |
| 13 | Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue 显示文摘 | Bae S Sun S Aghaloo T | 2014 | Int J Mol Med2014，34，2： | 1 |
| 14 | Platelet-rich plasma:ready or not显示文摘 | Freymiller EG Aghaloo TL | | 0，，04： | 1 |
| 15 | MicreCT evaluation of Three-Dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects显示文摘 | Cowan CM Aghaloo T Chou YF | 2007 | Tissue Eng2007，13，3： | 1 |
| 16 | Investigation of platelet- rich plasma in rabbit cranial defects: A pilot study 显示文摘 | Aghaloo TL Moy PK Freymiller EG | 2002 | J Oral Maaxillfac Surg2002，60，10： | 1 |
| 17 | Investigation of platelet-rich plasma in rabbit cranial defects:a pilot study显示文摘 | Aghaloo TL Moy PK Freymiller EG | 2002 | J Oral Maxillofac Surg2002，60，10： | 1 |
| 18 | Platelet-rich plasma: ready or not显示文摘 | Freymiller EG Aghaloo TL | 2004 | J Oral Maxillofac Surg2004，62，4： | 1 |
| 19 | Sinus membrane per- forations and the incidence of complications:a retrospec- tive study from a residency program 显示文摘 | Shiftier K Lee D Aghaloo T | 2015 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontolo- gy2015，38，1： | 1 |
| 20 | Investigation of platelet-rich plasma in rabbit cranial defects:a pilot study显示文摘 | Aghaloo TL Moy PK Freymiller EG | | 0，，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员