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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 3 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 4 | Muscle-sparing latissimus dorsi myocutaneous flap with maintenance of muscle innervation,function,and aesthetic appearance of the donor site显示文摘 | Schwabegger AH Harpf C Rainer C | 2003 | Plast Reconstr Surg2003，111，4： | 1 |
| 5 | Relationship among amioda- rone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome显示文摘 | Riera AR Uchida AH Ferreira C | 2008 | Cardiol J2008，15，3： | 1 |
| 6 | Mesenchymal stem cells in the dental tissues:perspectives for tissue regeneration显示文摘 | Estrela C Alencar AH Kitten GT | 2011 | Braz Dent J2011，22，2： | 1 |
| 7 | Thioredoxin-interacting pro tein is stimulated by glucose through a carbohydrate response element and induces β-cell apoptosis显示文摘 | Minn AH Hafele C Shalev A | 2005 | Endocrinology2005，146，5： | 1 |
| 8 | A randomized trial of frovatriptan for the intermittent prevention of menstrual migraine显示文摘 | Silberstein SD Elkind AH Schreiber C | 2004 | Neurology2004，63，： | 1 |
| 9 | Retention of fiber posts cemented at different time intervals in canals obturated using an epoxy resin sealer 显示文摘 | Vano M Cury AH Goracci C | 2008 | J Dent2008，36，10： | 1 |
| 10 | Development and cross-sec- tional validation of the Childhood Asthma Control Test显示文摘 | Liu AH Zeiger R Sorkness C | 2007 | J Al- lergy Clin Immunol2007，119，： | 1 |
| 11 | A novel resorption assay for osteoclast functionality based on an osteoblast-derived native extracellular matrix显示文摘 | Lutter AH Hempel U Wolf-Brandstetter C | | 0，，05： | 1 |
| 12 | Solvent extraction of the oils of rubber,melon, pumpkin and oilbean seeds 显示文摘 | ATI'AH J C IBEMESI J A | 1990 | J Am Oil Chem Soc1990，67，1： | 1 |
| 13 | Repair techniques for obstetric anal sphincter injuries: a randomized controlled tri- al 显示文摘 | Fernando R J Sultan AH Kettle C | 2006 | Obstet Gynecol2006，107，： | 1 |
| 14 | Diagnostic tools in tuber-culous pleurisy: a direct comparative study 显示文摘 | Diacon AH Vandewal BW Wyser C | 2003 | Eur Respir J2003，22，4： | 1 |
| 15 | The B-Lynch surgical technique for the control of massive postpartum haemorrhage:an alternative to hysterectong?Five case reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 16 | Bone formation in vitro by stromal cells obtained from bone显示文摘 | Maniatopoulos C Sodek J Melcher AH | 1988 | Cell Tissue Res1988，3，： | 1 |
| 17 | The B-Lynch surgical technique for the control of massive postpartum haemorrhage:analternative to hysterectomy?Five cases reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 18 | Primary and secondary thrombocytosis in child- hood显示文摘 | Dame C Sutor AH | 2005 | Br J Haematol2005，129，2： | 1 |
| 19 | Use of a type IAII bilayer collagen membrane decreases ropcmtion rates for symptomatic hypertrophy after autoiogous chondrocyte implantation 显示文摘 | Gomoll AH Probst C Fan: J | 2009 | Am J Sports Med2009，371，： | 1 |
| 20 | 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis 显示文摘 | Tate JE Burton AH Boschi-Pinto C | 2012 | Lancet Infect Dis2012，12，2： | 1 |
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